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Chemical Compound Review

Betanidine     1-benzyl-2,3-dimethyl- guanidine

Synonyms: Betaling, Bethanid, Eusmanid, Hypersin, Tenathan, ...
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Disease relevance of Bethanidine


High impact information on Bethanidine


Chemical compound and disease context of Bethanidine


Biological context of Bethanidine


Anatomical context of Bethanidine


Associations of Bethanidine with other chemical compounds


Gene context of Bethanidine

  • In this novel method for quantifying bethanidine in plasma, after a multi-step extraction of bethanidine and internal standard from 2.0 mL of plasma, the drugs are separated on a "microbore" C18 reversed-phase column and quantified by their ultraviolet absorbance at 210 nm [21].

Analytical, diagnostic and therapeutic context of Bethanidine


  1. Systemic hemodynamic effects of bethanidine in essential hypertension. Chrysant, S.G., Nishiyama, K., Adamopoulos, P.N., Frohlich, E.D. Circulation (1975) [Pubmed]
  2. Bethanidine sulfate: efficacy in prevention of ventricular tachyarrhythmias during programmed stimulation. Report of a multicenter study of 56 patients. Teichman, S.L., Waspe, L.E., Matos, J.A., Kim, S.G., Fisher, J.D. J. Am. Coll. Cardiol. (1985) [Pubmed]
  3. A comparison of the effects of bethanidine, meobentine and quinidine on the electrical activity of rat hearts in vivo and in vitro. Northover, B.J. Br. J. Pharmacol. (1985) [Pubmed]
  4. Suppression of ventricular fibrillation and positive inotropic action of bethanidine sulfate, a chemical analog of bretylium tosylate that is well absorbed orally. Bacaner, M.B., Hoey, M.F., Macres, M.G. Am. J. Cardiol. (1982) [Pubmed]
  5. Multiclinic controlled trial of bethanidine and guanethidine in severe hypertension. Ramirez, E.A., Elson, L., Gear, A.S., Oster, J.R., Talmers, F.N., Thomas, J.R. Circulation (1977) [Pubmed]
  6. Amiodarone: biochemical evidence for binding to a receptor for class I drugs associated with the rat cardiac sodium channel. Sheldon, R.S., Hill, R.J., Cannon, N.J., Duff, H.J. Circ. Res. (1989) [Pubmed]
  7. Site-directed mutagenesis and protein 3D-homology modelling suggest a catalytic mechanism for UDP-glucose-dependent betanidin 5-O-glucosyltransferase from Dorotheanthus bellidiformis. Hans, J., Brandt, W., Vogt, T. Plant J. (2004) [Pubmed]
  8. Cloning and expression of a cDNA encoding betanidin 5-O-glucosyltransferase, a betanidin- and flavonoid-specific enzyme with high homology to inducible glucosyltransferases from the Solanaceae. Vogt, T., Grimm, R., Strack, D. Plant J. (1999) [Pubmed]
  9. A comparison and an investigation of a potential synergistic effect of labetalol and bethanidine in patients with mild hypertension. Chalmers, A.G., Hunter, J., Lees, C.D., Millar, J.A., Brown, J.J., Robertson, J.I. British journal of clinical pharmacology. (1979) [Pubmed]
  10. Antiarrhythmic, antifibrillatory, and hemodynamic actions of bethanidine sulfate: an orally effective analog of bretylium for suppression of ventricular tachyarrhythmias. Bacaner, M.B., Benditt, D.G. Am. J. Cardiol. (1982) [Pubmed]
  11. Studies on bethanidine and meobentine: direct and indirect effects of antifibrillatory drugs. Dangman, K.H., Wang, H.H., Reynolds, R.D. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
  12. The combined effect of propranolol with bethanidine or methyldopa in hypertension. Prichard, B.N. Advances in clinical pharmacology. (1976) [Pubmed]
  13. Pharmacokinetics of bethanidine in hypertensive patients. Shen, D., Gibaldi, M., Israili, A., Bellward, G., Cunningham, R., Throne, M., Dayton, P., McNay, J. Clin. Pharmacol. Ther. (1975) [Pubmed]
  14. Substrate specificity and sequence analysis define a polyphyletic origin of betanidin 5- and 6-O-glucosyltransferase from Dorotheanthus bellidiformis. Vogt, T. Planta (2002) [Pubmed]
  15. Acute electrophysiologic effects of bethanidine sulfate in patients with ventricular tachycardia or fibrillation. DiMarco, J.P., Sellers, T.D., Shipe, J.R., Savory, J., Spyker, D.H. Am. Heart J. (1984) [Pubmed]
  16. Fluorometric assay of bethanidine in plasma. Corder, C.N., Klaniecki, T.S., McDonald, R.H., Berlin, C. Journal of pharmaceutical sciences. (1975) [Pubmed]
  17. Muscarinic receptors and parasympathetic neurotransmission in guinea-pig trachea. Yang, Z.J., Biggs, D.F. Eur. J. Pharmacol. (1991) [Pubmed]
  18. Electrophysiological effects of bethanidine sulfate on canine cardiac Purkinje fibers and ventricular muscle cells. Dangman, K.H., Miura, D.S. J. Cardiovasc. Pharmacol. (1985) [Pubmed]
  19. Bethanidine increases one type of potassium current and relaxes aortic muscle. Bkaily, G., Caillé, J.P., Payet, M.D., Peyrow, M., Sauvé, R., Renaud, J.F., Sperelakis, N. Can. J. Physiol. Pharmacol. (1988) [Pubmed]
  20. Are the characteristics of betanidin glucosyltransferases from cell-suspension cultures of Dorotheanthus bellidiformis indicative of their phylogenetic relationship with flavonoid glucosyltransferases? Vogt, T., Zimmermann, E., Grimm, R., Meyer, M., Strack, D. Planta (1997) [Pubmed]
  21. Determination of bethanidine in plasma by liquid-chromatography with a microbore reversed-phase column. Shipe, J.R., Arlinghaus, A.F., Savory, J., Wills, M.R., DiMarco, J.P. Clin. Chem. (1983) [Pubmed]
  22. Time-dependent change in renal clearance of bethanidine in humans. Chremos, A.N., Shen, D., Gibaldi, M., Proctor, J.D., Newman, J.H. Journal of pharmaceutical sciences. (1976) [Pubmed]
  23. Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs. Burgess, C.D., Turner, P., Wadsworth, J. British journal of clinical pharmacology. (1978) [Pubmed]
  24. Myocardial bethanidine kinetics after single-dose intravenous infusion: correlation with plasma kinetics in closed-chest dogs. Anderson, J.L., Anastasiou-Nana, M., Dayton, V.D., Creagar, R.N., Jensen, R.L., Wright, G.J. J. Cardiovasc. Pharmacol. (1985) [Pubmed]
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