Disease relevance of SODIUM VANADATE

• Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies [1].
• To investigate the efficacy and mechanism of action of sodium metavanadate as an oral hypoglycemic agent, five insulin-dependent diabetes mellitus (IDDM) and five noninsulin-dependent diabetes mellitus (NIDDM) patients were studied before and after 2 weeks of oral sodium metavanadate (NaVO3; 125 mg/day) [1].
• Normalization of STZ induced hyperglycemia by sodium metavanadate treatment or by replacement of exogenous insulin did not restore pancreatic PE activity [2].
• The present study evaluated the effect of administration of Tiron on sodium metavanadate (NaVO3)-induced developmental toxicity in mice [3].
• Dietary exposure of mallards to 250 ppm sodium metavanadate for 4 wk resulted in modest accumulation of V in liver and kidney (<5 microg/g dw) and mild intestinal hemorrhage [4].

High impact information on SODIUM VANADATE

• Diabetic rats given sodium metavanadate (0.5 mg in 0.5 ml of water by gavage twice daily; n = 8) had significantly lower food intakes (P < 0.001) than untreated diabetic rats [5].
• In vitro inhibition of Na+ sensitive ATPase by sodium metavanadate had an IC50 of 1.8 mM, whereas a 1.8-fold stimulation of adenylate cyclase in iris-ciliary body (ICB) membranes in vitro occurred at 10 mM but not at 10 microM Na metavanadate [6].
• We found that sodium metavanadate, an inhibitor of PTPase, reversibly blocked the spontaneous maturation in vitro of rat oocytes (ED50 = 0.26 mM) [7].
• Selected indices of copper metabolism in weanling rats and fibroblast cultures were progressively altered in response to increased levels of sodium metavanadate [8].
• Exposure to paraquat for 2.5 h did not increase microvascular permeability or pulmonary vascular resistance in the presence of either normal extracellular calcium or low extracellular calcium and sodium metavanadate [9].

Chemical compound and disease context of SODIUM VANADATE

• Also, vanadium treatment reduced the level of hyperglycemia in diabetic rats, with sodium metavanadate being the most effective of the vanadium compounds tested [10].

Biological context of SODIUM VANADATE

• Sodium metavanadate was found to be even more potent (LD50 = 37.2 mg/kg) in male Canada geese [4].
• Sodium metavanadate (2.5, 3.5 or 5.0 mg/kg) administration to rats, intraperitoneally, for 7, 3 or 2 consecutive days was found to enhance lipid peroxidation in various rat brain fractions [11].
• Sodium metavanadate was tested for its effects on fetal development, reproduction, gestation and lactation in Sprague Dawley rats [12].
• Embryotoxic effects of sodium metavanadate administered to rats during organogenesis [13].
• Fresh water was supplied to the dogs in the DC group, but sodium metavanadate solution (0.1~0.2 mg/ml) was given to the dogs in DV group from one week after the alloxan injection [14].

Anatomical context of SODIUM VANADATE

• A mouse macrophage cell line RAW 264.7 was treated with sodium metavanadate (NaVO3) at the dose of 0.5, 5, or 10 microg/mi V [15].
• In the present work we show morphological data of the in vivo susceptibility of CNS myelin to sodium metavanadate [V(+5)] in adult rats [16].
• Sodium metavanadate (NaVO3) was administered intraperitoneally on d 6-15 of gestation at doses of 0, 2, 4, or 8 mg/kg/d. On gestation d 18, all live fetuses were examined for external, visceral, and skeletal malformations and variations [17].

Associations of SODIUM VANADATE with other chemical compounds

• Male Wistar rats were treated in the period from conception up to the 105th day of age with 40 and 60 ppm of vanadium, given as sodium metavanadate in the drinking water [18].
• In the present investigation, the effects of oral administration of sodium metavanadate, sodium orthovanadate and vanadyl sulphate to alleviate some signs of diabetes in streptozotocin-treated rats have been evaluated [10].

Gene context of SODIUM VANADATE

• Using immunocytochemistry of BrdUrd-labeled cells and 3H-thymidine DNA fiber autoradiography, the effects of staurosporine (a potent inhibitor of cyclin-dependent kinases, CDKs) and sodium metavanadate (an inhibitor of protein phosphatases) on DNA endoreplication were investigated in primary roots of Pisum sativum [19].
• In human trials, insulin sensitivity improved in patients with NIDDM, as well as in some patients with IDDM after two weeks of treatment with sodium metavanadate [20].
• Using a rat model of acute lung inflammation induced by intratracheal instillation of sodium metavanadate (NaVO3) at the dose of 200 microg V/kg, we investigated the relationship between the cytologic characterization of pulmonary inflammation and the expression of chemokine mRNA [21].

Analytical, diagnostic and therapeutic context of SODIUM VANADATE

• In one catheter, the perfusion medium was supplemented with sodium metavanadate (10-100 mM) after a basal period, the other catheter served as control [22].

References