Chemical Compound Review:
Clofilium 4-(4-chlorophenyl)butyl- diethyl-heptyl...
Synonyms:
CHEMBL9484, SureCN157537, AG-G-62481, BSPBio_000318, CHEBI:105583, ...
- Antiarrhythmic effects of potassium channel openers in rhythm abnormalities related to delayed repolarization. Carlsson, L., Abrahamsson, C., Drews, L., Duker, G. Circulation (1992)
- Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium. Platia, E.V., Reid, P.R. Clin. Pharmacol. Ther. (1984)
- Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs. Rhodes, J., Chen, H., Hall, S.R., Beesley, J.E., Jenkins, D.C., Collins, P., Zheng, B. Nature (1995)
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- Antifibrillatory effects of clofilium in the rabbit isolated heart. Friedrichs, G.S., Chi, L., Green, A.L., Lucchesi, B.R. Br. J. Pharmacol. (1994)
- K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization. Hasumi, H., Matsuda, R., Shimamoto, K., Hata, Y., Kaneko, N. Eur. J. Pharmacol. (2007)
- The effect of bretylium and clofilium on dispersion of refractoriness and vulnerability to ventricular fibrillation in the ischemic feline heart. Kowey, P.R., Friehling, T.D., O'Connor, K.M., Wetstein, L., Kelliher, G.J. Am. Heart J. (1985)
- Prevention of clofilium-induced torsade de pointes by prostaglandin E2 does not involve ATP-dependent K+ channels. Farkas, A., Coker, S.J. Eur. J. Pharmacol. (2003)
- Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model. Dorian, P., Wang, M., David, I., Feindel, C. Circulation (1991)
- Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. Attali, B., Romey, G., Honoré, E., Schmid-Alliana, A., Mattéi, M.G., Lesage, F., Ricard, P., Barhanin, J., Lazdunski, M. J. Biol. Chem. (1992)
- Contribution of the IsK (MinK) potassium channel subunit to regulatory volume decrease in murine tracheal epithelial cells. Lock, H., Valverde, M.A. J. Biol. Chem. (2000)
- Structural determinants of HERG channel block by clofilium and ibutilide. Perry, M., de Groot, M.J., Helliwell, R., Leishman, D., Tristani-Firouzi, M., Sanguinetti, M.C., Mitcheson, J. Mol. Pharmacol. (2004)
- Functional IsK/KvLQT1 potassium channel in a new corticosteroid-sensitive cell line derived from the inner ear. Teixeira, M., Viengchareun, S., Butlen, D., Ferreira, C., Cluzeaud, F., Blot-Chabaud, M., Lombès, M., Ferrary, E. J. Biol. Chem. (2006)
- Xe991 reveals differences in K(+) channels regulating chloride secretion in murine airway and colonic epithelium. MacVinish, L.J., Guo, Y., Dixon, A.K., Murrell-Lagnado, R.D., Cuthbert, A.W. Mol. Pharmacol. (2001)
- Block of single batrachotoxin-activated Na+ channels by clofilium. Nettleton, J., Castle, N.A., Wang, G.K. Mol. Pharmacol. (1991)
- Molecular basis for the inhibition of 1,4-dihydropyridine calcium channel drugs binding to their receptors by a nonspecific site interaction mechanism. Young, H.S., Skita, V., Mason, R.P., Herbette, L.G. Biophys. J. (1992)
- Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs. Perry, M., Stansfeld, P.J., Leaney, J., Wood, C., de Groot, M.J., Leishman, D., Sutcliffe, M.J., Mitcheson, J.S. Mol. Pharmacol. (2006)
- Voltage-gated K+ currents in freshly isolated myocytes of the pregnant human myometrium. Knock, G.A., Smirnov, S.V., Aaronson, P.I. J. Physiol. (Lond.) (1999)
- Tandem-pore domain potassium channels are functionally expressed in retinal (Müller) glial cells. Skatchkov, S.N., Eaton, M.J., Shuba, Y.M., Kucheryavykh, Y.V., Derst, C., Veh, R.W., Wurm, A., Iandiev, I., Pannicke, T., Bringmann, A., Reichenbach, A. Glia (2006)
- Oxidant stress stimulates anion secretion from the human airway epithelial cell line Calu-3: implications for cystic fibrosis lung disease. Cowley, E.A., Linsdell, P. J. Physiol. (Lond.) (2002)
- Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Gessner, G., Heinemann, S.H. Br. J. Pharmacol. (2003)
- Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. Gessner, G., Zacharias, M., Bechstedt, S., Schönherr, R., Heinemann, S.H. Mol. Pharmacol. (2004)
- Modulation of calcium-dependent chloride secretion by basolateral SK4-like channels in a human bronchial cell line. Bernard, K., Bogliolo, S., Soriani, O., Ehrenfeld, J. J. Membr. Biol. (2003)
- Schiff base-mediated co-stimulation primes the T-cell-receptor-dependent calcium signalling pathway in CD4 T cells. Hall, S.R., Rhodes, J. Immunology (2001)
- Contractile effects of porcine galanin(1-29)-NH2 on the rat isolated gastric fundus: mediation by potassium ions. Korolkiewicz, R., Takeuchi, K., Sliwinski, W., Konstanski, Z., Rekowski, P., Szyk, A. Pharmacol. Res. (1997)
- Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel. Malayev, A.A., Nelson, D.J., Philipson, L.H. Mol. Pharmacol. (1995)
- Effects of clofilium on ischemic subendocardial Purkinje fibers 1 day postinfarction. Gough, W.B., Hu, D., el-Sherif, N. J. Am. Coll. Cardiol. (1988)
- Block of gating currents related to K+ channels as a mechanism of action of clofilium and d-sotalol in isolated guinea-pig ventricular heart cells. Malécot, C.O., Argibay, J.A. Br. J. Pharmacol. (1999)
- Nasal drug delivery system of a quaternary ammonium compound: clofilium tosylate. Su, K.S., Campanale, K.M., Gries, C.L. Journal of pharmaceutical sciences. (1984)
- Antiarrhythmic and electrophysiologic actions of clofilium in experimental canine models. Kopia, G.A., Eller, B.T., Patterson, E., Shea, M.J., Lucchesi, B.R. Eur. J. Pharmacol. (1985)