Chemical Compound Review:
Loreclezol 1-[(Z)-2-chloro-2-(2,4...
Synonyms:
Loreclezole, Loreclezolum, Tocris-1295, AC1MHWQV, CHEMBL1397886, ...
- Effects of loreclezole on epileptic activity and on EEG and behaviour in rats with absence seizures. Ates, N., van Luijtelaar, E.L., Drinkenburg, W.H., Vossen, J.M., Coenen, A.M. Epilepsy Res. (1992)
- In vivo studies on the mechanism of action of the broad spectrum anticonvulsant loreclezole. Ashton, D., Fransen, J., Heeres, J., Clincke, G.H., Janssen, P.A. Epilepsy Res. (1992)
- Effects of loreclezole on metrazol-induced phenomena in developing rats. Pohl, M., Mares, P. Archives internationales de pharmacodynamie et de thérapie. (1990)
- The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole. Groves, J.O., Guscott, M.R., Hallett, D.J., Rosahl, T.W., Pike, A., Davies, A., Wafford, K.A., Reynolds, D.S. Eur. J. Neurosci. (2006)
- Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Luszczki, J.J., Ratnaraj, N., Patsalos, P.N., Czuczwar, S.J. Naunyn Schmiedebergs Arch. Pharmacol. (2006)
- A novel allosteric modulatory site on the GABAA receptor beta subunit. Wafford, K.A., Bain, C.J., Quirk, K., McKernan, R.M., Wingrove, P.B., Whiting, P.J., Kemp, J.A. Neuron (1994)
- The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Wingrove, P.B., Wafford, K.A., Bain, C., Whiting, P.J. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Smith, A.J., Alder, L., Silk, J., Adkins, C., Fletcher, A.E., Scales, T., Kerby, J., Marshall, G., Wafford, K.A., McKernan, R.M., Atack, J.R. Mol. Pharmacol. (2001)
- Amino acid neurotransmission and initiation of puberty: evidence from nonketotic hyperglycinemia in a female infant and gonadotropin-releasing hormone secretion by rat hypothalamic explants. Bourguignon, J.P., Jaeken, J., Gerard, A., de Zegher, F. J. Clin. Endocrinol. Metab. (1997)
- beta-Carboline gamma-aminobutyric acidA receptor inverse agonists modulate gamma-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site. Stevenson, A., Wingrove, P.B., Whiting, P.J., Wafford, K.A. Mol. Pharmacol. (1995)
- A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Green, A.R., Misra, A., Murray, T.K., Snape, M.F., Cross, A.J. Neuropharmacology (1996)
- Loreclezole inhibition of recombinant alpha1beta1gamma2L GABA(A) receptor single channel currents. Fisher, J.L., Hinkle, D.J., Macdonald, R.L. Neuropharmacology (2000)
- Interactions between loreclezole, chlormethiazole and pentobarbitone at GABA(A) receptors: functional and binding studies. Zhong, Y., Simmonds, M.A. Br. J. Pharmacol. (1997)
- Effects of the triazole derivative loreclezole (R72063) on stimulus induced ionic and field potential responses and on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex-hippocampal slices. Zhang, C.L., Heinemann, U. Naunyn Schmiedebergs Arch. Pharmacol. (1992)
- Single-dose efficacy evaluation of loreclezole in patients with photosensitive epilepsy. Overweg, J., De Beukelaar, F. Epilepsy Res. (1990)
- Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor. Boulineau, N., Baur, R., Minier, F., Sigel, E. J. Neurochem. (2005)
- Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. Priestley, C.M., Williamson, E.M., Wafford, K.A., Sattelle, D.B. Br. J. Pharmacol. (2003)
- Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Sanna, E., Murgia, A., Casula, A., Usala, M., Maciocco, E., Tuligi, G., Biggio, G. Neuropharmacology (1996)
- Zurich Consensus Conference on New Antiepileptic Drugs. Introduction: goals. Wieser, H.G. Epilepsia (1994)
- Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors. Smith, A.J., Oxley, B., Malpas, S., Pillai, G.V., Simpson, P.B. J. Pharmacol. Exp. Ther. (2004)
- Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents. Donnelly, J.L., MacDonald, R.L. Neuropharmacology (1996)
- U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors. Im, H.K., Im, W.B., Pregenzer, J.F., Carter, D.B., Hamilton, B.J. J. Pharmacol. Exp. Ther. (1995)
- Efficacy and safety evaluation of loreclezole as add-on treatment in therapy-resistant epilepsy patients. Rentmeester, T., Hulsman, J. Epilepsy Res. (1991)
- Loreclezole and La3+ differentiate cerebellar granule cell GABA(A) receptor subtypes. Mäkelä, R., Wisden, W., Korpi, E.R. Eur. J. Pharmacol. (1999)