Disease relevance of Anemia, Macrocytic

• Mice with the recessive hereditary disease, Hertwig's anemia (an/an), exhibit a persistent mild macrocytic anemia and reduced fertility [1].
• Deficiency of folate can lead to many clinical abnormalities, including macrocytic anemia, cardiovascular diseases, birth defects, and carcinogenesis [2].
• Monkeys fed diets containing 0.14 or 0.27 mg of added folic acid per kilogram of dry diet slowly developed alopecia, a scaly dermatitis, and a mild macrocytic anemia [3].
• Dose-related thrombocytopenia and macrocytic anemia associated with valproate use in bipolar disorder [4].
• Lesch-Nyhan syndrome is caused by a severe genetic deficiency of hypoxanthine phosphoribosyltransferase (HPRT) and is characterized by central nervous system disorders, gout, and in some cases, macrocytic anemia [5].

Psychiatry related information on Anemia, Macrocytic

• This suggests that macrocytic anemia was a common feature of alcoholic and non-alcoholic liver cirrhosis and that alcohol abuse and folic acid deficiency play a secondary role in macrocytosis [6].

High impact information on Anemia, Macrocytic

• Loss of function mutations at either the W or Sl loci lead to a variety of pleiotropic developmental defects, including mast cell deficiency and severe macrocytic anemia [7].
• Mice homozygous for Hertwig's anemia, an/an, have a mild macrocytic anemia and are refractory to the potentially curative action of exogenously administered erythropoietin (EP) [8].
• During clinical use of stearyl-ara-CMP, macrocytic anemia was observed, and some patients also developed megaloblastic change of their erythroblasts, suggesting a mild and persistent cytostatic effect [9].
• BACKGROUND: The perinatal prophylactic administration of zidovudine is associated with rapidly reversible macrocytic anemia in infants [10].
• Intractable epilepsy as the presentation of vitamin B deficiency in the absence of macrocytic anemia [11].

Chemical compound and disease context of Anemia, Macrocytic

• Macrocytic anemia developed in one child receiving simultaneous long-term trimethoprim-sulfamethoxazole therapy and resolved after the trimethoprim-sulfamethoxazole was discontinued [12].
• The fish exposed to actellic suffered macrocytic anemia [13].
• Acivicin caused some growth effects and a macrocytic anemia, but no other clinical or biochemical side effects [14].
• Macrocytic anemia during low-dose cisplatin and 5-Fluorouracil through implanted infusion port for unresectable hepatobilliary malignancies [15].
• During the follow-up, the insulin requirement decreased and even ceased, and macrocytic anemia improved with thiamine treatment [16].

Biological context of Anemia, Macrocytic

• In this study, we report that W/W mutant mice, which have severe macrocytic anemia caused by a deficit of extracellular domain in c-kit molecules and therefore die perinatally, have hemopoietic stem cells (HSCs) and mature hematolymphoid cells in the bone marrow (BM), thymus, and spleen, although there are significant decreases in cell counts [17].
• This boy represents a case of macrocytic anemia and hypotonia owing to vitamin B12 deficiency that developed because of exclusive breast-feeding by a vegetarian mother [18].

Anatomical context of Anemia, Macrocytic

• AZT alone caused hematopoietic toxicity with dose-related bone marrow suppression, macrocytic anemia, and thrombocytosis [19].
• Three years after starting valproate, he developed erythrocyte aplasia with a severe, normochromic, macrocytic anemia requiring several blood transfusions [20].

Gene context of Anemia, Macrocytic

• Mutations in the erythroid-specific ALA synthase 2 (ALAS2) gene cause microcytic anemia, whereas mitochondrial DNA deletions are responsible for Pearsons syndrome with a macrocytic anemia [21].
• Two cases of severe myeloneuropathy and macrocytic anemia associated with a low serum level of vitamin B12 after prolonged exposure to nitrous oxide are reported [22].
• PATIENT AND METHODS: An 11-year-old girl with Turner syndrome was found to have mild macrocytic anemia that persisted during 2 years [23].
• Macrocytic anemia and thrombocytosis associated with thymoma: a case report [24].
• Moreover, vitamin B12 does not reverse the associated macrocytic anemia nor are the neurological deficits of MS improved following supplementation with vitamin B12 [25].

References