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MeSH Review

Anemia, Macrocytic

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Disease relevance of Anemia, Macrocytic


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Chemical compound and disease context of Anemia, Macrocytic


Biological context of Anemia, Macrocytic


Anatomical context of Anemia, Macrocytic


Gene context of Anemia, Macrocytic

  • Mutations in the erythroid-specific ALA synthase 2 (ALAS2) gene cause microcytic anemia, whereas mitochondrial DNA deletions are responsible for Pearsons syndrome with a macrocytic anemia [21].
  • Two cases of severe myeloneuropathy and macrocytic anemia associated with a low serum level of vitamin B12 after prolonged exposure to nitrous oxide are reported [22].
  • PATIENT AND METHODS: An 11-year-old girl with Turner syndrome was found to have mild macrocytic anemia that persisted during 2 years [23].
  • Macrocytic anemia and thrombocytosis associated with thymoma: a case report [24].
  • Moreover, vitamin B12 does not reverse the associated macrocytic anemia nor are the neurological deficits of MS improved following supplementation with vitamin B12 [25].


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  2. Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. Courtemanche, C., Elson-Schwab, I., Mashiyama, S.T., Kerry, N., Ames, B.N. J. Immunol. (2004) [Pubmed]
  3. Folacin deficiency and requirement in the squirrel monkey (Saimiri sciuresus). Rasmussen, K.M., Thenen, S.W., Hayes, K.C. Am. J. Clin. Nutr. (1979) [Pubmed]
  4. Dose-related thrombocytopenia and macrocytic anemia associated with valproate use in bipolar disorder. Fawcett, R.G. The Journal of clinical psychiatry. (1997) [Pubmed]
  5. Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells. Hakoda, M., Hirai, Y., Akiyama, M., Yamanaka, H., Terai, C., Kamatani, N., Kashiwazaki, S. Hum. Genet. (1995) [Pubmed]
  6. Red blood cell status in alcoholic and non-alcoholic liver disease. Maruyama, S., Hirayama, C., Yamamoto, S., Koda, M., Udagawa, A., Kadowaki, Y., Inoue, M., Sagayama, A., Umeki, K. J. Lab. Clin. Med. (2001) [Pubmed]
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  9. Clinical pharmacology of 1-beta-D-arabinofuranosylcytosine-5'-stearylphosphate, an orally administered long-acting derivative of low-dose 1-beta-D-arabinofuranosylcytosine. Ueda, T., Kamiya, K., Urasaki, Y., Wataya, S., Kawai, Y., Tsutani, H., Sugiyama, M., Nakamura, T. Cancer Res. (1994) [Pubmed]
  10. Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants. Le Chenadec, J., Mayaux, M.J., Guihenneuc-Jouyaux, C., Blanche, S. AIDS (2003) [Pubmed]
  11. Intractable epilepsy as the presentation of vitamin B deficiency in the absence of macrocytic anemia. Lee, M., Chang, H.S., Wu, H.T., Weng, H.H., Chen, C.M. Epilepsia (2005) [Pubmed]
  12. Morbidity associated with long-term methotrexate therapy in juvenile rheumatoid arthritis. Graham, L.D., Myones, B.L., Rivas-Chacon, R.F., Pachman, L.M. J. Pediatr. (1992) [Pubmed]
  13. Erythropoietic response and hematological parameters in the catfish Clarias albopunctatus exposed to sublethal concentrations of actellic. Mgbenka, B.O., Oluah, N.S., Arungwa, A.A. Ecotoxicol. Environ. Saf. (2005) [Pubmed]
  14. Prevention of diabetes in the spontaneously diabetic BB rat by the glutamine antimetabolite acivicin. Misra, M., Duguid, W.P., Marliss, E.B. Can. J. Physiol. Pharmacol. (1996) [Pubmed]
  15. Macrocytic anemia during low-dose cisplatin and 5-Fluorouracil through implanted infusion port for unresectable hepatobilliary malignancies. Yamamoto, N., Murata, K., Fuke, H., Inoue, T., Yamanaka, Y., Saitou, Y., Ito, K., Sugimoto, K., Koyama, M., Shiraki, K., Nakano, T. Anticancer Res. (2005) [Pubmed]
  16. Thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness. Akinci, A., Teziç, T., Ertürk, G., Tarim, O., Dalva, K. Acta paediatrica Japonica; Overseas edition. (1993) [Pubmed]
  17. Stimulatory effects of hepatocyte growth factor on hemopoiesis of SCF/c-kit system-deficient mice. Yu, C.Z., Hisha, H., Li, Y., Lian, Z., Nishino, T., Toki, J., Adachi, Y., Inaba, M., Fan, T.X., Jin, T., Iguchi, T., Sogo, S., Hosaka, N., Song, T.H., Xing, J., Ikehara, S. Stem Cells (1998) [Pubmed]
  18. Answer to hypotonia: a simple hemogram. Kanra, G., Cetin, M., Unal, S., Haliloglu, G., Akça, T., Akalan, N., Kara, A. J. Child Neurol. (2005) [Pubmed]
  19. Subchronic toxicity of human immunodeficiency virus and tuberculosis combination therapies in B6C3F1 mice. Rao, G.N., Lindamood, C., Heath, J.E., Farnell, D.R., Giles, H.D. Toxicol. Sci. (1998) [Pubmed]
  20. Valproate use associated with persistent hyperammonemia and mitochondrial injury in a child with Down's syndrome. Kane, R.E., Kotagel, S., Bacon, B.R., Vogler, C.A. J. Pediatr. Gastroenterol. Nutr. (1992) [Pubmed]
  21. The molecular basis of the sideroblastic anemias. Fitzsimons, E.J., May, A. Curr. Opin. Hematol. (1996) [Pubmed]
  22. Methionine in the treatment of nitrous-oxide-induced neuropathy and myeloneuropathy. Stacy, C.B., Di Rocco, A., Gould, R.J. J. Neurol. (1992) [Pubmed]
  23. Myelodysplasia associated with Turner syndrome. Foster, L.A., Abboud, M.R., Taylor, A.B., Barredo, J., Lazarchick, J., Laver, J. J. Pediatr. Hematol. Oncol. (1996) [Pubmed]
  24. Macrocytic anemia and thrombocytosis associated with thymoma: a case report. Grumbeck, E., Aiginger, P., Gisslinger, B., Geissler, K., Thalhammer-Scherrer, R., Gisslinger, H. Am. J. Hematol. (2000) [Pubmed]
  25. Vitamin B12 and its relationship to age of onset of multiple sclerosis. Sandyk, R., Awerbuch, G.I. Int. J. Neurosci. (1993) [Pubmed]
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