The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L1Q5E     1,1,2,3,3,4- hexachlorocyclohexane; 1,1,2,3...

Synonyms: 27154-44-5, Cyclohexane, hexachloro-
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hexachlorocyclohexane


High impact information on Hexachlorocyclohexane


Chemical compound and disease context of Hexachlorocyclohexane


Biological context of Hexachlorocyclohexane


Anatomical context of Hexachlorocyclohexane


Associations of Hexachlorocyclohexane with other chemical compounds

  • The promoting action of hexachlorocyclohexane (HCH) was evaluated in female Wistar rats by counting the gamma-glutamyltranspeptidase-positive foci which appeared in the liver after diethylnitrosamine (DENA) initiation [24].
  • Ten PCB congeners, five DDT isomers, hexachlorobenzene, three hexachlorocyclohexane isomers, trans-nonachlor and oxychlordane were analyzed by gas chromatography [25].
  • Concentrations of persistent organochlorines (OCs) such as polychlorinated biphenyls (PCBs), DDT and its metabolites (DDTs), hexachlorocyclohexane isomers (HCHs), and chlordane compounds (CHLs) were determined in whole body soft tissue homogenates and in muscles of resident and migratory birds collected from Lake Baikal, Russia [26].
  • Concentrations of hexachlorocyclohexane (HCH) isomers (alpha, beta, and gamma) and enantiomer fractions (EFs) of alpha-HCH were determined in the Northwater Polynya Arctic marine food web [27].
  • PFOS was the major contaminant detected in most samples and in polar bear liver was the most prominent organohalogen (mean PFOS = 3.1 microg/g wet weight) compared to individual polychlorinated biphenyl congeners, chlordane, or hexachlorocyclohexane-related chemicals in fat [28].

Gene context of Hexachlorocyclohexane


Analytical, diagnostic and therapeutic context of Hexachlorocyclohexane


  1. Cloning and characterization of lin genes responsible for the degradation of Hexachlorocyclohexane isomers by Sphingomonas paucimobilis strain B90. Kumari, R., Subudhi, S., Suar, M., Dhingra, G., Raina, V., Dogra, C., Lal, S., van der Meer, J.R., Holliger, C., Lal, R. Appl. Environ. Microbiol. (2002) [Pubmed]
  2. Risk of non-Hodgkin's lymphoma and exposure to hexachlorocyclohexane, a nested case-control study. Rafnsson, V. Eur. J. Cancer (2006) [Pubmed]
  3. Anaerobic dechlorination and degradation of hexachlorocyclohexane isomers by anaerobic and facultative anaerobic bacteria. Jagnow, G., Haider, K., Ellwardt, P.C. Arch. Microbiol. (1977) [Pubmed]
  4. Ocular rosacea. Browning, D.J., Proia, A.D. Survey of ophthalmology. (1986) [Pubmed]
  5. Differential effects of hexachlorocyclohexane isomers on the GABA receptor subunits expressed in human embryonic kidney cell line. Nagata, K., Huang, C.S., Hamilton, B.J., Carter, D.B., Narahashi, T. Brain Res. (1996) [Pubmed]
  6. Reversible activation of the neutrophil superoxide generating system by hexachlorocyclohexane: correlation with effects on a subcellular superoxide-generating fraction. English, D., Schell, M., Siakotos, A., Gabig, T.G. J. Immunol. (1986) [Pubmed]
  7. Inhibition of phosphatidylinositol synthase and other membrane-associated enzymes by stereoisomers of hexachlorocyclohexane. Parries, G.S., Hokin-Neaverson, M. J. Biol. Chem. (1985) [Pubmed]
  8. Control of hepatocyte DNA synthesis by intracellular pH and its role in the action of tumor promoters. Lee, C.H., Cragoe, E.J., Edwards, A.M. J. Cell. Physiol. (2003) [Pubmed]
  9. Stimulation of DNA synthesis in primary rat hepatocyte cultures by liver tumor promoters: interactions with other growth factors. Yusof, Y.A., Edwards, A.M. Carcinogenesis (1990) [Pubmed]
  10. Comparative formation of chlorophenol metabolites from hexachlorocyclohexane in mouse and rat in vivo and in vitro. Munir, K.M., Nair, J., Bhide, S.V. Carcinogenesis (1984) [Pubmed]
  11. Is there a correlation between organochlorine compounds and undescended testes? Hosie, S., Loff, S., Witt, K., Niessen, K., Waag, K.L. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie. (2000) [Pubmed]
  12. Influence of protein deficiency on hexachlorocyclohexane and malathion toxicity in pregnant rats. Prabhakaran, S., Shameem, F., Devi, K.S. Veterinary and human toxicology. (1993) [Pubmed]
  13. Animal poisonings: the 10-year experience of a veterinary analytical toxicology laboratory. Guitart, R., Manosa, S., Guerrero, X., Mateo, R. Veterinary and human toxicology. (1999) [Pubmed]
  14. Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat. Joseph, P., Shivanandappa, T., Narasimhamurthy, K., Krishnakumari, M.K. Gen. Pharmacol. (1992) [Pubmed]
  15. Effect of nutrients on the toxicity of pesticides carbofuran and hexachlorocyclohexane to blue-green alga Nostoc muscorum. Kar, S., Singh, P.K. Z. Allg. Mikrobiol. (1979) [Pubmed]
  16. Dynamics of multiple lin gene expression in Sphingomonas paucimobilis B90A in response to different hexachlorocyclohexane isomers. Suar, M., van der Meer, J.R., Lawlor, K., Holliger, C., Lal, R. Appl. Environ. Microbiol. (2004) [Pubmed]
  17. Distribution and phylogeny of hexachlorocyclohexane-degrading bacteria in soils from Spain. Mohn, W.W., Mertens, B., Neufeld, J.D., Verstraete, W., de Lorenzo, V. Environ. Microbiol. (2006) [Pubmed]
  18. Composition of microbial communities in hexachlorocyclohexane (HCH) contaminated soils from Spain revealed with a habitat-specific microarray. Neufeld, J.D., Mohn, W.W., de Lorenzo, V. Environ. Microbiol. (2006) [Pubmed]
  19. Effects of hexachlorocyclohexane isomers on the mitogenic response of bovine lymphocytes. Kensler, T.W., Mueller, G.C. Biochem. Pharmacol. (1978) [Pubmed]
  20. The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes. Aspinwall, L.S., Bermudez, I., King, L.A., Wafford, K.A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  21. Hexachlorocyclohexane pesticides reduce survival and alter plasma membrane structure of Chinese hamster V79 cells. Verma, S.P., Rastogi, A., Lin, P.S. Arch. Biochem. Biophys. (1992) [Pubmed]
  22. Oxidative transformation of hexachlorocyclohexane in rats and with rat liver microsomes. Stein, K., Portig, J., Koransky, W. Naunyn Schmiedebergs Arch. Pharmacol. (1977) [Pubmed]
  23. Effect of hexachlorocyclohexane isomers on calmodulin mRNA expression in the central nervous system. Barrón, S., Tusell, J.M., Serratosa, J. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  24. Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz[a]anthracene initiation in mouse. Munir, K.M., Rao, K.V., Bhide, S.V. Carcinogenesis (1984) [Pubmed]
  25. Organochlorines and bone mineral density in Swedish men from the general population. Glynn, A.W., Michaëlsson, K., Lind, P.M., Wolk, A., Aune, M., Atuma, S., Darnerud, P.O., Mallmin, H. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2000) [Pubmed]
  26. Seasonal variation of persistent organochlorine accumulation in birds from Lake Baikal, Russia, and the role of the south Asian region as a source of pollution for wintering migrants. Kunisue, T., Minh, T.B., Fukuda, K., Watanabe, M., Tanabe, S., Titenko, A.M. Environ. Sci. Technol. (2002) [Pubmed]
  27. Hexachlorocyclohexane (HCH) isomers and chiral signatures of alpha-HCH in the Arctic marine food web of the Northwater Polynya. Moisey, J., Fisk, A.T., Hobson, K.A., Norstrom, R.J. Environ. Sci. Technol. (2001) [Pubmed]
  28. Identification of long-chain perfluorinated acids in biota from the Canadian Arctic. Martin, J.W., Smithwick, M.M., Braune, B.M., Hoekstra, P.F., Muir, D.C., Mabury, S.A. Environ. Sci. Technol. (2004) [Pubmed]
  29. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Danzo, B.J. Environ. Health Perspect. (1997) [Pubmed]
  30. Effect of in utero exposure to hexachlorocyclohexane on the developing immune system of mice. Das, S.N., Paul, B.N., Saxena, A.K., Ray, P.K. Immunopharmacology and immunotoxicology. (1990) [Pubmed]
  31. Mediation of oxidative stress in HCH-induced neurotoxicity in rat. Sahoo, A., Samanta, L., Chainy, G.B. Arch. Environ. Contam. Toxicol. (2000) [Pubmed]
  32. Changes in rat testicular antioxidant defence profile as a function of age and its impairment by hexachlorocyclohexane during critical stages of maturation. Samanta, L., Roy, A., Chainy, G.B. Andrologia (1999) [Pubmed]
  33. Action of polychlorocycloalkane insecticides on binding of [35S]t-butylbicyclophosphorothionate to Torpedo electric organ membranes and stereospecificity of the binding site. Matsumoto, K., Eldefrawi, M.E., Eldefrawi, A.T. Toxicol. Appl. Pharmacol. (1988) [Pubmed]
  34. Experimental studies on insecticides commonly used in India. Nigam, S.K., Bhatt, D.K., Karnik, A.B., Thakore, K.N., Aravinda Babu, K., Lakkad, B.C., Kashyap, S.K., Chatterjee, S.K. J. Cancer Res. Clin. Oncol. (1981) [Pubmed]
  35. Reductive dechlorination of beta-hexachlorocyclohexane (beta-HCH) by a Dehalobacter species in coculture with a Sedimentibacter sp. van Doesburg, W., van Eekert, M.H., Middeldorp, P.J., Balk, M., Schraa, G., Stams, A.J. FEMS Microbiol. Ecol. (2005) [Pubmed]
  36. Age-related changes in rat testicular oxidative stress parameters by hexachlorocyclohexane. Samanta, L., Sahoo, A., Chainy, G.B. Arch. Toxicol. (1999) [Pubmed]
  37. Epithelial binding of hexachlorocyclohexanes in the respiratory and upper alimentary tracts: a comparison between the alpha-, beta- and gamma-isomers in mice. Brittebo, E.B., Högman, P.G., Brandt, I. Food Chem. Toxicol. (1987) [Pubmed]
  38. Exposure of tilapian fish to the pesticide lindane results in hypocellularity of the primary hematopoietic organ (pronephros) and the spleen without altering activity of phagocytic cells in these organs. Hart, L.J., Smith, S.A., Smith, B.J., Robertson, J., Holladay, S.D. Toxicology (1997) [Pubmed]
WikiGenes - Universities