Disease relevance of pheniramine

• A double-blind parallel trial of astemizole, pheniramine and placebo was carried out in 51 patients with hay fever [1].
• CONCLUSION: In this patient sample, studied in a CAC model of onset of action, prophylactic pheniramine/naphazoline was more effective than olopatadine and placebo in alleviating the signs and symptoms of the acute ocular allergic reaction, as measured by the OAI [2].
• OBJECTIVES: To assess the relative clinical toxicity of pheniramine compared with other antihistamines taken in overdose and its relative use for self-poisoning [3].
• Comparison of Naphcon-A and its components (naphazoline and pheniramine) in a provocative model of allergic conjunctivitis [4].
• Cardiovascular toxicity including ventricular extrasystoles associated with pheniramine overdosage has been documented in the absence of factors recognised to aggravate this toxicity [5].

Psychiatry related information on pheniramine

• A very high proportion of the pheniramine group had a history of drug or alcohol abuse (79.9%) [3].

High impact information on pheniramine

• The antihistamines diphenhydramine, pheniramine, doxylamine, orphenadrine, methapyrilene and pyrilamine, gave IC50 values of 100-500 microM [6].
• However, the affinities of the tested H1-antagonists other than mepyramine for this binding site were quite low and the known stereospecificity displayed by the histamine H1-receptor for the enantiomers of chlorpheniramine and pheniramine was not found [7].
• The natural abundance carbon-13 magnetic resonance spectra of a series of antihistamines (pheniramine, chlorpheniramine, methapyrilene, tripelennamine, pyrilamine, and thonzylamine) were detemined using the pulse Fourier transform technique [8].
• Hybrid molecules combining the crucial structural features of both pheniramine-type histamine H1 receptor antagonists and guanidinothiazole-type H2 receptor antagonists have been synthesized and tested for in vitro pharmacological activity at the isolated ileum and the spontaneously beating right atrium of the guinea-pig [9].
• Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine [10].

Chemical compound and disease context of pheniramine

• Summary--Ru-Vert, a combination product, containing in each tablet, 25 mg of pentylenetetrazol, 12.5 mg of pheniramine maleate, and 50 mg of nictonic acid, was evaluated in the treatment of seventeen patients with benign paroxysmal positional vertigo [11].

Biological context of pheniramine

• The pharmacokinetics of pheniramine and its two metabolites (N-desmethyl pheniramine and N-didesmethyl pheniramine) were determined in six healthy male subjects after intravenous (n = 3) or oral (n = 3) administration (30.5 mg of pheniramine - free base) [12].
• Action of anti-allergic agent pheniramine maleate on mammalian somatic & meiotic chromosomes [13].
• On i.p. administration, both H1- (pheniramine and astemizole) and H2-receptor antagonists (ranitidine and cimetidine) were observed to produce significant enhancement of anti-SRBC antibody response [14].

Anatomical context of pheniramine

• OBJECTIVE: To differentiate the effects of three antiallergic H1-antihistamine drugs (pheniramine, chlor- and brompheniramine) on radical formation outside and inside human neutrophils [10].
• The spontaneous peristaltic reflex of the goat ureter (7 +/- 2 per 2 min) showed a 50% increase in the frequency of contraction (13.66 +/- 1.6, P<0.001) after application of histamine at a concentration of between 6.512 muM and 13.024 muM, but was blocked completely by 10.4 muM of pheniramine (P>0.05) [15].

Associations of pheniramine with other chemical compounds

• However, olopatadine was approximately 10-fold more potent as an inhibitor of cytokine secretion (50% inhibitory concentration, 1.7-5.5 nmol/L) than predicted from binding data, while antazoline and pheniramine were far less potent (20- to 140-fold) in functional assays [16].
• Norit or another proven effective activated charcoal would be of value in first-aid treatment of pheniramine poisoning [17].
• Pharmacokinetics of pheniramine (Avil) and metabolites in healthy subjects after oral and intravenous administration [12].

Analytical, diagnostic and therapeutic context of pheniramine

• Enantioselective determination of pheniramine in pharmaceuticals by capillary electrophoresis with charged cyclodextrin [18].
• Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods [19].
• After i.v. administration, serum concentrations of pheniramine between 231 and 894 ng/ml were reached and after oral administration peak serum concentrations between 173 and 274 ng/ml were reached after 1-2.5 h [12].

References