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Chemical Compound Review

pheniramine     N,N-dimethyl-3-phenyl-3- pyridin-2-yl...

Synonyms: Trimeton, Tripoton, Pyriton, Feniramina, Avil, ...
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Disease relevance of pheniramine


Psychiatry related information on pheniramine


High impact information on pheniramine


Chemical compound and disease context of pheniramine


Biological context of pheniramine


Anatomical context of pheniramine

  • OBJECTIVE: To differentiate the effects of three antiallergic H1-antihistamine drugs (pheniramine, chlor- and brompheniramine) on radical formation outside and inside human neutrophils [10].
  • The spontaneous peristaltic reflex of the goat ureter (7 +/- 2 per 2 min) showed a 50% increase in the frequency of contraction (13.66 +/- 1.6, P<0.001) after application of histamine at a concentration of between 6.512 muM and 13.024 muM, but was blocked completely by 10.4 muM of pheniramine (P>0.05) [15].

Associations of pheniramine with other chemical compounds


Analytical, diagnostic and therapeutic context of pheniramine


  1. Astemizole in the treatment of hay fever. Malmberg, H., Holopainen, E., Grahne, B., Binder, E., Savolainen, S., Sundberg, S. Allergy (1983) [Pubmed]
  2. A comparison of the clinical efficacy of pheniramine maleate/naphazoline hydrochloride ophthalmic solution and olopatadine hydrochloride ophthalmic solution in the conjunctival allergen challenge model. Greiner, J.V., Udell, I.J. Clinical therapeutics. (2005) [Pubmed]
  3. Pheniramine--a much abused drug. Buckley, N.A., Whyte, I.M., Dawson, A.H., Cruickshank, D.A. Med. J. Aust. (1994) [Pubmed]
  4. Comparison of Naphcon-A and its components (naphazoline and pheniramine) in a provocative model of allergic conjunctivitis. Dockhorn, R.J., Duckett, T.G. Curr. Eye Res. (1994) [Pubmed]
  5. Cardiovascular complications due to pheniramine overdosage. Bobik, A., McLean, A.J. Australian and New Zealand journal of medicine. (1976) [Pubmed]
  6. Methadone: a potent inhibitor of rat liver aldehyde oxidase. Robertson, I.G., Gamage, R.S. Biochem. Pharmacol. (1994) [Pubmed]
  7. High affinity, saturable [3H]mepyramine binding sites on rat liver plasma membrane do not represent histamine H1-receptors. A warning. Leurs, R., Bast, A., Timmerman, H. Biochem. Pharmacol. (1989) [Pubmed]
  8. Carbon-13 magnetic resonance spectroscopy of drugs II: antihistamines. Chang, C.J., Peck, G.E. Journal of pharmaceutical sciences. (1976) [Pubmed]
  9. Combined histamine H1/H2 receptor antagonists: part II. Pharmacological hybrids with pheniramine- and tiotidine-like substructures. Wolf, C., Schulze, F.R., Buschauer, A., Schunack, W. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (1998) [Pubmed]
  10. Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine. Jancinova, V., Drabikova, K., Nosal, R., Holomanova, D. Neuro Endocrinol. Lett. (2006) [Pubmed]
  11. Benign paroxysmal positonal vertigo: A clinical study. Herndon, J.W., Haug, O., Horowitz, M.J., Lynes, T.E. The Annals of otology, rhinology, and laryngology. (1975) [Pubmed]
  12. Pharmacokinetics of pheniramine (Avil) and metabolites in healthy subjects after oral and intravenous administration. Witte, P.U., Irmisch, R., Hajdú, P. International journal of clinical pharmacology, therapy, and toxicology. (1985) [Pubmed]
  13. Action of anti-allergic agent pheniramine maleate on mammalian somatic & meiotic chromosomes. Subramanyam, S., Ganeshan, S., Devi, P. Indian J. Exp. Biol. (1981) [Pubmed]
  14. Possible role of histamine receptors in the central regulation of immune responses. Moharana, A.K., Bhattacharya, S.K., Mediratta, P.K., Sharma, K.K. Indian J. Physiol. Pharmacol. (2000) [Pubmed]
  15. Goat ureter-an alternative model for measuring ureteral peristalsis. Smita, K., Sushil Kumar, V., Premendran, J., Sharma, M.L. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi (2006) [Pubmed]
  16. Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs. Yanni, J.M., Weimer, L.K., Sharif, N.A., Xu, S.X., Gamache, D.A., Spellman, J.M. Arch. Ophthalmol. (1999) [Pubmed]
  17. Reduction of pheniramine toxicity using activated charcoal. Boehm, J.J., Brown, T.C., Oppenheim, R.C. Clin. Toxicol. (1978) [Pubmed]
  18. Enantioselective determination of pheniramine in pharmaceuticals by capillary electrophoresis with charged cyclodextrin. Mikus, P., Valásková, I., Havránek, E. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  19. Chiral separation of pheniramine-like 3-phenyl-3-heteroarylpropylamines by CE and HPLC methods. Schuster, A., Götte, C., Bernhardt, G., Buschauer, A. Chirality. (2001) [Pubmed]
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