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Chemical Compound Review

Dimetane     3-(4-bromophenyl)-N,N- dimethyl-3-pyridin-2...

Synonyms: Bromfed, Bromfenex, Brotane, Lodrane, Veltane, ...
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Disease relevance of BROMPHENIRAMINE


Psychiatry related information on BROMPHENIRAMINE


High impact information on BROMPHENIRAMINE


Chemical compound and disease context of BROMPHENIRAMINE


Biological context of BROMPHENIRAMINE


Anatomical context of BROMPHENIRAMINE

  • N-Oxygenation of brompheniramine in both microsomes and with highly purified FMO from hog liver was enantioselective [14].
  • Although some N-demethylation was observed, the major metabolite of brompheniramine and the other tertiary amines examined in hog liver microsomes was the metabolite containing an aliphatic nitrogen N-oxide [14].
  • Whereas BPA significantly suppressed No/UL, metiamide significantly reduced No/UL and VD in statistical terms suggesting that endogenous mast-cell histamine is angiogenic through both H1- and H2-receptors [15].
  • OBJECTIVE: To differentiate the effects of three antiallergic H1-antihistamine drugs (pheniramine, chlor- and brompheniramine) on radical formation outside and inside human neutrophils [16].

Associations of BROMPHENIRAMINE with other chemical compounds




Analytical, diagnostic and therapeutic context of BROMPHENIRAMINE


  1. Efficacy of brompheniramine maleate for the treatment of rhinovirus colds. Gwaltney, J.M., Druce, H.M. Clin. Infect. Dis. (1997) [Pubmed]
  2. The acute effect of phenylpropanolamine and brompheniramine on blood pressure in controlled hypertension: a randomized double-blind crossover trial. Petrulis, A.S., Imperiale, T.F., Speroff, T. Journal of general internal medicine : official journal of the Society for Research and Education in Primary Care Internal Medicine. (1991) [Pubmed]
  3. Nasal pharmacodynamics of brompheniramine in perennial rhinitis. Georgitis, J.W., Shen, D. Arch. Otolaryngol. Head Neck Surg. (1988) [Pubmed]
  4. Pregnancy after brompheniramine treatment of a diabetic with incomplete emission failure. Schill, W.B. Arch. Androl. (1990) [Pubmed]
  5. Longterm treatment with brompheniramine and phenylpropanolamine in recurrent otitis media--a double-blind study. Kjellman, N.I., Harder, H., Lindwall, L., Synnerstad, B. The Journal of otolaryngology. (1978) [Pubmed]
  6. Histaminergic systems and sleep. Studies in man with H1 and H2 antagonists. Nicholson, A.N., Pascoe, P.A., Stone, B.M. Neuropharmacology (1985) [Pubmed]
  7. First do no harm: managing antihistamine impairment in patients with allergic rhinitis. Casale, T.B., Blaiss, M.S., Gelfand, E., Gilmore, T., Harvey, P.D., Hindmarch, I., Simons, F.E., Spangler, D.L., Szefler, S.J., Terndrup, T.E., Waldman, S.A., Weiler, J., Wong, D.F. J. Allergy Clin. Immunol. (2003) [Pubmed]
  8. The clinical pharmacology of brompheniramine in children. Simons, F.E., Roberts, J.R., Gu, X., Kapur, S., Simons, K.J. J. Allergy Clin. Immunol. (1999) [Pubmed]
  9. The comparative actions and adverse effect profile of single doses of H1-receptor antihistamines in the airways and skin of subjects with asthma. Wood-Baker, R., Holgate, S.T. J. Allergy Clin. Immunol. (1993) [Pubmed]
  10. The pharmacokinetics and antihistaminic effects of brompheniramine. Simons, F.E., Frith, E.M., Simons, K.J. J. Allergy Clin. Immunol. (1982) [Pubmed]
  11. Effect of food on bioavailability of pseudoephedrine and brompheniramine administered from a gastrointestinal therapeutic system. Chao, S.T., Prather, D., Pinson, D., Coen, P., Pruitt, B., Knowles, M., Place, V. Journal of pharmaceutical sciences. (1991) [Pubmed]
  12. Electrophysiological effects of brompheniramine on cardiac ion channels and action potential. Shin, W.H., Kim, K.S., Kim, E.J. Pharmacol. Res. (2006) [Pubmed]
  13. Alkylamine antihistamine toxicity and review of Pediatric Toxicology Registry of the National Association of Medical Examiners. Report 4: Alkylamines. Jumbelic, M.I., Hanzlick, R., Cohle, S. The American journal of forensic medicine and pathology : official publication of the National Association of Medical Examiners. (1997) [Pubmed]
  14. Tertiary amines related to brompheniramine: preferred conformations for N-oxygenation by the hog liver flavin-containing monooxygenase. Cashman, J.R., Celestial, J.R., Leach, A., Newdoll, J., Park, S.B. Pharm. Res. (1993) [Pubmed]
  15. Mast-cell histamine is angiogenic through receptors for histamine1 and histamine2. Sörbo, J., Jakobsson, A., Norrby, K. International journal of experimental pathology. (1994) [Pubmed]
  16. Extra- and intracellular formation of reactive oxygen species by human neutrophils in the presence of pheniramine, chlorpheniramine and brompheniramine. Jancinova, V., Drabikova, K., Nosal, R., Holomanova, D. Neuro Endocrinol. Lett. (2006) [Pubmed]
  17. Metabolites of chlorpromazine and brompheniramine may cause false-positive urine amphetamine results with monoclonal EMIT d.a.u. immunoassay. Olsen, K.M., Gulliksen, M., Christophersen, A.S. Clin. Chem. (1992) [Pubmed]
  18. Brompheniramine, terfenadine, and placebo in allergic rhinitis. Klein, G.L., Littlejohn, T., Lockhart, E.A., Furey, S.A. Ann. Allergy Asthma Immunol. (1996) [Pubmed]
  19. Single and repeated dose comparison of three antihistamines and phenylpropanolamine: psychomotor performance and subjective appraisals of sleep. Seppälä, T., Nuotto, E., Korttila, K. British journal of clinical pharmacology. (1981) [Pubmed]
  20. Anticholinergic properties of brompheniramine, chlorpheniramine, and atropine in human nasal mucosa in vitro. Fang, S.Y., Druce, H.M., Baraniuk, J.N. American journal of rhinology. (1998) [Pubmed]
  21. The comparative pharmacokinetics of H1-receptor antagonists. Simons, F.E., Simons, K.J., Chung, M., Yeh, J. Annals of allergy. (1987) [Pubmed]
  22. Separation of brompheniramine enantiomers by capillary electrophoresis and study of chiral recognition mechanisms of cyclodextrins using NMR-spectroscopy, UV spectrometry, electrospray ionization mass spectrometry and X-ray crystallography. Chankvetadze, B., Burjanadze, N., Pintore, G., Bergenthal, D., Bergander, K., Mühlenbrock, C., Breitkreuz, J., Blaschke, G. Journal of chromatography. A. (2000) [Pubmed]
  23. Brompheniramine, loratadine, and placebo in allergic rhinitis: a placebo-controlled comparative clinical trial. Druce, H.M., Thoden, W.R., Mure, P., Furey, S.A., Lockhart, E.A., Xie, T., Galant, S., Prenner, B.M., Weinstein, S., Ziering, R., Brandon, M.L. Journal of clinical pharmacology. (1998) [Pubmed]
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