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Chemical Compound Review

AC1NQXSM     7-[(1R,2S,3R,5S)-3,5- dihydroxy-2-[(E,3S)-3...

Synonyms: PGF1alpha, PGF 1-alpha, PGF1|A, CHEMBL1325783, SureCN1477281, ...
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Disease relevance of PGF 1-alpha


High impact information on PGF 1-alpha


Biological context of PGF 1-alpha

  • The increase in lobar arterial pressure in response to PGF1alpha and PGF2alpha was associated with a significant increase in lobar venous pressure but no change in left atrial pressure [10].
  • In conclusion, in poorly controlled diabetes, there was no differential lack of aspirin sensitivity to platelet aggregation, or lack of aspirin suppression of urinary TxB2 or PGF1alpha, compared with controls on aspirin [11].

Anatomical context of PGF 1-alpha

  • The changes with time in intrauterine tissue production and concentrations of PGE-2, PGF-2 alpha, 6-keto PGF-1 alpha and PGFM (13,14-dihydro-15-keto PGF-2 alpha) in maternal and fetal plasma and amniotic fluid were investigated during the first 72 h of pulsatile administration of ACTH1-24 to chronically catheterized fetal sheep [12].
  • It is concluded that exogenous progesterone administered on dioestrus II inhibits granulosa PGE and 6-keto PGF-1 alpha accumulation in preovulatory follicles, probably by reducing serum LH concentrations, and that the granulosa cells, which are LH-dependent, are a major source of follicular PGE [13].
  • Other unlabeled PGs such as PGF1alpha, PGE2 (5-fold), PGE1 (120-fold), PGA1 and PGB1 (about 10,000-fold) were less effective when compared to unlabeled PGF2alpha in inhibiting [3H] PGF2alpha binding to the membranes [14].
  • PGF1alpha treatment increased the tonus of the smooth muscle cells in the wall of the tubules as indicated by a reduction in the diameter of the tubules [15].
  • Significantly less PGF-1 alpha, PGF-2 alpha and 12-hydroxyheptadecatrienoic acid (HHT) were found in the capillaries of MFO treated animals, in comparison to the SFO group [16].

Associations of PGF 1-alpha with other chemical compounds


Analytical, diagnostic and therapeutic context of PGF 1-alpha


  1. Urinary prostaglandins (PGE2 and PGI2) in hyporeninaemic hypoaldosteronism in diabetic patients with chronic renal failure. Gómez-Martino, J.R., Miralles, J.M., De Leon, B., Hernandez, M.T., Tabernero, J.M. Nephrol. Dial. Transplant. (1994) [Pubmed]
  2. Origin of prostaglandins in human semen. Gerozissis, K., Jouannet, P., Soufir, J.C., Dray, F. J. Reprod. Fertil. (1982) [Pubmed]
  3. Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster. Gregor, J.I., Kilian, M., Heukamp, I., Kiewert, C., Kristiansen, G., Schimke, I., Walz, M.K., Jacobi, C.A., Wenger, F.A. Prostaglandins Leukot. Essent. Fatty Acids (2005) [Pubmed]
  4. Calcium channel blockers in experimental acute pancreatitis: effect on tissue prostanoids and oxygen free radicals. Closa, D., Hotter, G., Bulbena, O., Gelpi, E., Rosello-Catafau, J. Pancreas (1996) [Pubmed]
  5. Effect of aspirin treatment on plasma levels of keto PGF 1 alpha and thromboxane B2. Madan, Z.M., Sainani, G.S. The Journal of the Association of Physicians of India. (1995) [Pubmed]
  6. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Reid, G., Wielinga, P., Zelcer, N., van der Heijden, I., Kuil, A., de Haas, M., Wijnholds, J., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Hormonal responsiveness of adenylate cyclase activity in cartilage. Smith, D.M., Roth, L.M., Johnston, C.C. Endocrinology (1976) [Pubmed]
  8. Prostaglandins, endotoxin and lipid A on body temperature in rats. Feldberg, W., Saxena, P.N. J. Physiol. (Lond.) (1975) [Pubmed]
  9. Modulation of phagocytosis by and lysosomal enzyme secretion from guinea-pig neutrophils: effect of nonsteroid anti-inflammatory agents and prostaglindins. Smith, R.J. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  10. Comparison of the effects of prostaglandins F1alpha, F2alpha, F1beta, and F2beta on the canine pulmonary vascular bed. Kadowitz, P.J., Joiner, P.D., Hyman, A.L. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  11. Aspirin sensitivity of platelet aggregation in diabetes mellitus. Albert, S.G., Hasnain, B.I., Ritter, D.G., Joist, J.H., Mooradian, A.D. Diabetes Res. Clin. Pract. (2005) [Pubmed]
  12. Early changes in prostaglandin concentrations in ovine maternal and fetal plasma, amniotic fluid and from dispersed cells of intrauterine tissues before the onset of ACTH-induced pre-term labour. Olson, D.M., Lye, S.J., Skinner, K., Challis, J.R. J. Reprod. Fertil. (1984) [Pubmed]
  13. Exogenous progesterone reduces follicular prostaglandin E and 6-keto prostaglandin F-1 alpha in the cyclic hamster. Brannian, J.D., Terranova, P.F. J. Reprod. Fertil. (1990) [Pubmed]
  14. Properties of prostaglandin F2alpha receptors in bovine corpus luteum cell membranes. Rao, C.V. Mol. Cell. Endocrinol. (1976) [Pubmed]
  15. Contractility of rat testicular seminiferous tubules in vitro: prostaglandin f 1 alpha and indomethacin-1,2. Buhrley, L.E., Ellis, L.C. Prostaglandins (1975) [Pubmed]
  16. Dietary manipulation with high marine fish oil intake of fatty acid composition and arachidonic acid metabolism in rat cerebral microvessels. Kálmán, J., Gecse, A., Farkas, T., Joó, F., Telegdy, G., Lajtha, A. Neurochem. Res. (1992) [Pubmed]
  17. Evidence for the involvement of oxygen-derived free radicals in ischaemia-reperfusion injury. Ward, A., McBurney, A., Lunec, J. Free Radic. Res. (1994) [Pubmed]
  18. Renal protective effect of liposomed superoxide dismutase in an experimental warm ischemia model. Torras, J., Seron, D., Herrero, I., Martinez-Castelao, A., Carrera, M., Alsina, J., Griño, J.M. Transpl. Int. (1994) [Pubmed]
  19. Radioimmunoassay of prostaglandins and thromboxane B2 in extracted and unextracted urine and serum using an iodinated ligand. Mahoney, D.P., Barden, A., Beilin, L.J., Vandongen, R. Prostaglandins, leukotrienes, and medicine. (1983) [Pubmed]
  20. Release of prostaglandin F1alpha and F2alpha from superfused platelets: quantitative evaluation of the inhibitory effects of some aspirin-like drugs. Patrono, C., Ciabattoni, G., Crossi-Belloni, D. Prostaglandins (1975) [Pubmed]
  21. Study of prostaglandins and intraocular pressure in rabbits after Nd:YAG laser anterior segment procedures. Liu, S.J., Hunter, D.M., Oei, T., Lin, T., Lam, K.W. Ophthalmic surgery. (1988) [Pubmed]
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