Chemical Compound Review:
AC1NRATW 3-[[(2S)-2-[[(1R)-1- [[(1R,2R)-1-carboxy-4...
Synonyms:
PEPTIDOMIMETIC INHIBITOR
Adjei,
Davis,
Erlichman,
Svingen,
Kaufmann,
Sirotnak,
Sepp-Lorenzino,
Kohl,
Rosen,
Scher,
Sarisky,
Petroková,
Dusková,
Dohnálek,
Skálová,
Vondrácková-Buchtelová,
Soucek,
Konvalinka,
Brynda,
Fábry,
Sedlácek,
Hasek,
Reiser,
Hinrichsen,
Benhamou,
Reesink,
Wedemeyer,
Avendano,
Riba,
Yong,
Nehmiz,
Steinmann,
Lin,
Gates,
Rao,
Brennan,
Fulghum,
Luong,
Frantz,
Lin,
Ma,
Wei,
Perni,
Kwong,
- Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Reiser, M., Hinrichsen, H., Benhamou, Y., Reesink, H.W., Wedemeyer, H., Avendano, C., Riba, N., Yong, C.L., Nehmiz, G., Steinmann, G.G. Hepatology (2005)
- An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction. Mills, N.L., Daugherty, M.D., Frankel, A.D., Guy, R.K. J. Am. Chem. Soc. (2006)
- The crystal structure of the Epstein-Barr virus protease shows rearrangement of the processed C terminus. Buisson, M., Hernandez, J.F., Lascoux, D., Schoehn, G., Forest, E., Arlaud, G., Seigneurin, J.M., Ruigrok, R.W., Burmeister, W.P. J. Mol. Biol. (2002)
- CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity. Alteri, E., Bold, G., Cozens, R., Faessler, A., Klimkait, T., Lang, M., Lazdins, J., Poncioni, B., Roesel, J.L., Schneider, P. Antimicrob. Agents Chemother. (1993)
- Ureido-based peptidomimetic inhibitor of herpes simplex virus ribonucleotide reductase: an investigation of inhibitor bioactive conformation. Moss, N., Beaulieu, P., Duceppe, J.S., Ferland, J.M., Gauthier, J., Ghiro, E., Goulet, S., Guse, I., Llinàs-Brunet, M., Plante, R., Plamondon, L., Wernic, D., Déziel, R. J. Med. Chem. (1996)
- Reversible conformational changes induced in glycoprotein IIb-IIIa by a potent and selective peptidomimetic inhibitor. Kouns, W.C., Kirchhofer, D., Hadváry, P., Edenhofer, A., Weller, T., Pfenninger, G., Baumgartner, H.R., Jennings, L.K., Steiner, B. Blood (1992)
- The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. Dalton, M.B., Fantle, K.S., Bechtold, H.A., DeMaio, L., Evans, R.M., Krystosek, A., Sinensky, M. Cancer Res. (1995)
- A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Sepp-Lorenzino, L., Ma, Z., Rands, E., Kohl, N.E., Gibbs, J.B., Oliff, A., Rosen, N. Cancer Res. (1995)
- Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways. Gate, L., Majumdar, R.S., Lunk, A., Tew, K.D. J. Biol. Chem. (2004)
- Comparison of potential markers of farnesyltransferase inhibition. Adjei, A.A., Davis, J.N., Erlichman, C., Svingen, P.A., Kaufmann, S.H. Clin. Cancer Res. (2000)
- In vitro studies of cross-resistance mutations against two hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061. Lin, C., Gates, C.A., Rao, B.G., Brennan, D.L., Fulghum, J.R., Luong, Y.P., Frantz, J.D., Lin, K., Ma, S., Wei, Y.Y., Perni, R.B., Kwong, A.D. J. Biol. Chem. (2005)
- VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells. Lin, K., Perni, R.B., Kwong, A.D., Lin, C. Antimicrob. Agents Chemother. (2006)
- Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors. Petroková, H., Dusková, J., Dohnálek, J., Skálová, T., Vondrácková-Buchtelová, E., Soucek, M., Konvalinka, J., Brynda, J., Fábry, M., Sedlácek, J., Hasek, J. Eur. J. Biochem. (2004)
- Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine. Lee, C.W., Cao, H., Ichiyama, K., Rana, T.M. Bioorg. Med. Chem. Lett. (2005)
- Pharmacology and clinical experience with saquinavir. Kravcik, S. Expert opinion on pharmacotherapy. (2001)
- Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity. Devadas, B., Freeman, S.K., Zupec, M.E., Lu, H.F., Nagarajan, S.R., Kishore, N.S., Lodge, J.K., Kuneman, D.W., McWherter, C.A., Vinjamoori, D.V., Getman, D.P., Gordon, J.I., Sikorski, J.A. J. Med. Chem. (1997)
- Overexpression of the HIV-1 gag-pol polyprotein results in intracellular activation of HIV-1 protease and inhibition of assembly and budding of virus-like particles. Karacostas, V., Wolffe, E.J., Nagashima, K., Gonda, M.A., Moss, B. Virology (1993)
- Characterization of recombinant human renin: kinetics, pH-stability, and peptidomimetic inhibitor binding. Holzman, T.F., Chung, C.C., Edalji, R., Egan, D.A., Martin, M., Gubbins, E.J., Krafft, G.A., Wang, G.T., Thomas, A.M., Rosenberg, S.H. J. Protein Chem. (1991)
- Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Foy, E., Li, K., Wang, C., Sumpter, R., Ikeda, M., Lemon, S.M., Gale, M. Science (2003)
- Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. Ruscoe, J.E., Rosario, L.A., Wang, T., Gaté, L., Arifoglu, P., Wolf, C.R., Henderson, C.J., Ronai, Z., Tew, K.D. J. Pharmacol. Exp. Ther. (2001)
- Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock. Hu, J., Van den Steen, P.E., Dillen, C., Opdenakker, G. Biochem. Pharmacol. (2005)
- Non-nucleoside inhibitors of the HCV polymerase. Sarisky, R.T. J. Antimicrob. Chemother. (2004)
- Simultaneous monitoring of argatroban and its major metabolite using an HPLC method: potential clinical applications. Ahmad, S., Ahsan, A., George, M., Iqbal, O., Jeske, W.P., McKenna, R., Lewis, B.E., Walenga, J.M., Fareed, J. Clin. Appl. Thromb. Hemost. (1999)
- Clinical laboratory monitoring of a synthetic antithrombin agent, argatroban, using high performance liquid chromatography and functional methods. Ahmad, S., Iqbal, O., Ahsan, A., Hoppensteadt, D.A., Lewis, B.E., Walenga, J.M., Fareed, J. International angiology : a journal of the International Union of Angiology. (1999)
- Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain. Tokonzaba, E., Capelluto, D.G., Kutateladze, T.G., Overduin, M. Chemical biology & drug design. (2006)
- FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Xia, W., Ostaszewski, B.L., Kimberly, W.T., Rahmati, T., Moore, C.L., Wolfe, M.S., Selkoe, D.J. Neurobiol. Dis. (2000)
- Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases. Wilson, A.L., Erdman, R.A., Castellano, F., Maltese, W.A. Biochem. J. (1998)
- Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells. O'Malley, P.G., Sangster, S.M., Abdelmagid, S.A., Bearne, S.L., Too, C.K. Biochem. J. (2005)
- Structure-based design of a macrocyclic inhibitor for peptide deformylase. Hu, X., Nguyen, K.T., Verlinde, C.L., Hol, W.G., Pei, D. J. Med. Chem. (2003)
- A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility. Sirotnak, F.M., Sepp-Lorenzino, L., Kohl, N.E., Rosen, N., Scher, H.I. Cancer Chemother. Pharmacol. (2000)
- Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling. Majer, F., Pavlícková, L., Majer, P., Hradilek, M., Dolejsí, E., Hrusková-Heidingsfeldová, O., Pichová, I. Biol. Chem. (2006)