Disease relevance of Trichlormethylfos

• Chlorpyrifos-methyl, a wide-spectrum organophosphorus insecticide and potential toxic pollutant contaminating aquatic ecosystems, was investigated for acute toxicity [1].
• Relative liver weight was increased with decrease of body weight by CPM 250 mg/kg treatment [2].
• Biological control including larvivorous fishes, using of local made Bacillus thuringiensis and larvicides such as chlorpyrifos-methyl are the main larval control in the region [3].

High impact information on Trichlormethylfos

• In the present study we explored whether environmental exposures to 1-naphthol (1N), a metabolite of carbaryl and naphthalene, and 3,5,6-trichloro-2-pyridinol (TCPY), a metabolite of chlorpyrifos and chlorpyrifos-methyl, are associated with decreased semen quality in humans [4].
• The reactions of five organophosphorus insecticides (OPs) (chlorpyrifos-methyl, parathion-methyl, fenchlorphos, chlorpyrifos, and parathion) with hydrogensulfide/ bisulfide (H2S/HS-) and polysulfides (S(n)2-) were examined in well-defined aqueous solutions over a pH range from 5 to 9 [5].
• The reactions of chlorpyrifos-methyl with hydrogensulfide/bisulfide (H2S/HS-), polysulfides (Sn(2-)), thiophenolate (PhS-), and thiosulfate (S2O3(2-)) were examined in well-defined aqueous solutions over a pH range from 5 to 9 [6].
• The F11 adult population exhibited high levels of resistance to dichlorvos (48 times) and chlorpyrifos-methyl (40.1 times) insecticides propoxur, Mobam, Landrin or carbaryl, or to the chrysanthemate insecticide cismethrin [7].
• Environmental exposure to chlorpyrifos, chlorpyrifos-methyl, or its metabolite TCPY may be associated with altered thyroid function in human males [8].

Chemical compound and disease context of Trichlormethylfos

• The acute toxicity of chlorpyrifos, methylchlorpyrifos, parathion and methylparathion to three age classes of Artemia salina was determined [9].
• Also, ethanol and petroleum-ether extracts synergized the toxicity of reldan and permethrin, respectively, in the same insect [10].
• The toxicities of 44 plant essential oils against larvae of Cadra cautella (Walker) were examined using direct contact and vapor phase toxicity bioassays and compared with the lethal activity of chlorpyrifos-methyl, diazinon, dichlorvos, and fenthion, four widely used organophosphorus insecticides [11].

Biological context of Trichlormethylfos

• Trichloropyridinol, the major product of hydrolysis of chlorpyrifos-methyl, is only a minor product of the reaction of chlorpyrifos-methyl with bisulfide; however, trichloropyridinol was found to be stable under the experimental conditions [12].
• Chlorpyrifos-methyl use in citrus, vineyards and vegetables is extensive and it has become an essential component of pest control in Southern European regions [13].
• Uterine cell proliferation tested with bromodeoxyuridine labeling index was not observed in CPM treated rats [2].
• This paper describes the tissue distributions of dichlorvos, an organophosphate, and chlorpyrifos-methyl, an organophosphorothioate, in a male individual who died after ingesting an insecticidal preparation containing these chemicals and the results of an in vitro stability study on dichlorvos and chlorpyrifos-methyl in blood and buffers [14].
• Bioavailability and biological activity of wheat-bound chlorpyrifos-methyl residues in rats [15].

Anatomical context of Trichlormethylfos

• Chlorpyrifos-methyl dissipation in a small adjacent water body following application to citrus [13].
• Uterine and vaginal weight, uterine epithelial cell height were not affected by the treatment of CPM (2, 10, 50, 250 mg/kg) [2].
• Substantial amounts (0.615-4.15 mg/L) of chlorpyrifos-methyl were detected in all blood samples, and the order of its concentrations was as follows: pulmonary vessel blood > thoracic inferior vena caval blood > blood in the right cardiac chambers > blood in the left cardiac chambers approximately thoracic aortic blood > right femoral venous blood [14].
• In conclusion, CPM dose not show estrogenic and anti-estrogenic activity in immature female rats, but it represents anti-androgenic activity by inhibition of the TP-stimulated increase of the weight of accessory sex organs [2].
• While CPM induced the increase of relative adrenal gland weight, CPM 50mg/kg decreased the weights of CV/CG, VP, CG and LABC without change of GP without changing of GP when it was treated with TP [2].

Associations of Trichlormethylfos with other chemical compounds

• The hydrolysis rate of chlorpyrifos, O-O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphorothioate, and its dimethyl analog, chlorpyrifos-methyl, in dilute aqueous solution [16].
• The larvicidal activity of chlorpyrifos-methyl and temephos was evaluated against Culex pipiens L [17].
• Biochemical mechanisms of resistance in strains of Oryzaephilus surinamensis (Coleoptera: Silvanidae) resistant to malathion and chlorpyrifos-methyl [18].
• Biological monitoring was carried out by assaying urinary dimethylated alkylphosphates [dimethyldithiophosphate (DMDTP), dimethylthio-phosphate (DMTP), and dimethylphosphate (DMP)] in 11 workers exposed to chlorpyrifos-methyl and azinphosmethyl during operations in a previously sprayed peach orchard [19].

Gene context of Trichlormethylfos

• Longevity and lifetime fecundity were significantly reduced after topical application of LC10, LC20, and LC60's of chlorpyrifos-methyl to 2-d-old female German cockroaches, Blattella germanica (L.). Low concentrations (LC10 and LC20) often resulted in failure of the first ootheca to hatch [20].
• BACKGROUND & OBJECTIVES: Indoor residual spraying of Reldan 40% EC @ 0.5 and 1 g/m2 was done in Tatarpur and Chauna villages, respectively in Dhaulana PHC, Distt [21].

Analytical, diagnostic and therapeutic context of Trichlormethylfos

• Results of thin layer chromatography suggested the formation of a chlorpyrifos-methyl mercury complex [22].
• Electrochemical bioassay for the investigation of chlorpyrifos-methyl in vine samples [23].
• Data obtained from the chlorpyrifos-methyl acute toxicity tests were evaluated using Finney's probit analysis statistical method [1].

References