Chemical Compound Review:
LOXORIBINE 2-amino-9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...
Synonyms:
Loxoribina, Loxoribinum, SureCN61782, CHEMBL292008, RWJ-21757, ...
- Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Goodman, M.G., Wormsley, S.B., Spinosa, J.C., Piro, L.D. Blood (1994)
- 7-Allyl-8-oxoguanosine (loxoribine) inhibits the metastasis of B16 melanoma cells and has adjuvant activity in mice immunized with a B16 tumor vaccine. Pope, B.L., Sigindere, J., Chourmouzis, E., MacIntyre, P., Goodman, M.G. Cancer Immunol. Immunother. (1994)
- In vivo activation of natural killer cells and priming of IL-2 responsive cytolytic cells by loxoribine (7-allyl-8-oxoguanosine). Pope, B.L., Chourmouzis, E., Sigindere, J., MacIntyre, J.P., Capetola, R.J., Lau, C.Y. Cell. Immunol. (1993)
- Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole. Keenan, J.A., Williams-Boyce, P.K., Massey, P.J., Chen, T.T., Caudle, M.R., Bukovsky, A. Fertil. Steril. (1999)
- Topology of the loxoribine binding site. Studies with inactive loxoribine analogues. Goodman, M.G., Goodman, J.H. J. Immunol. (1994)
- Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2. Pope, B.L., Chourmouzis, E., Victorino, L., MacIntyre, J.P., Capetola, R.J., Lau, C.Y. J. Immunol. (1993)
- The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Heil, F., Ahmad-Nejad, P., Hemmi, H., Hochrein, H., Ampenberger, F., Gellert, T., Dietrich, H., Lipford, G., Takeda, K., Akira, S., Wagner, H., Bauer, S. Eur. J. Immunol. (2003)
- Phase 1, randomized, double-blind trial of 7-allyl-8-oxoguanosine (loxoribine) in advanced cancer. Agarwala, S.S., Kirkwood, J.M., Bryant, J. Cytokines Cell. Mol. Ther. (2000)
- New perspectives on the approach to chronic lymphocytic leukemia. Goodman, M.G., Spinosa, J.C., Saven, A., Piro, L.D., Wormsley, S. Leuk. Lymphoma (1996)
- A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine. Goodman, M.G. Pharmaceutical biotechnology. (1995)
- The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines. Pope, B.L., MacIntyre, J.P., Kimball, E., Lee, S., Zhou, L., Taylor, G.R., Goodman, M.G. Cell. Immunol. (1995)
- Murine strain variation in the natural killer cell and proliferative responses to the immunostimulatory compound 7-allyl-8-oxoguanosine: role of cytokines. Pope, B.L., Chourmouzis, E., MacIntyre, J.P., Lee, S., Goodman, M.G. Cell. Immunol. (1994)
- Recognition of pathogen-associated molecular patterns by TLR family. Akira, S., Hemmi, H. Immunol. Lett. (2003)
- Expression and function of Toll-like receptors in chicken heterophils. Kogut, M.H., Iqbal, M., He, H., Philbin, V., Kaiser, P., Smith, A. Dev. Comp. Immunol. (2005)
- Disparate expression of IL-12 by SJL/J and B10.S macrophages during Theiler's virus infection is associated with activity of TLR7 and mitogen-activated protein kinases. Petro, T.M. Microbes Infect. (2005)
- Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens. Philbin, V.J., Iqbal, M., Boyd, Y., Goodchild, M.J., Beal, R.K., Bumstead, N., Young, J., Smith, A.L. Immunology (2005)
- In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Pope, B.L., Chourmouzis, E., Sigindere, J., Capetola, R.J., Lau, C.Y. Int. J. Immunopharmacol. (1992)