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Gene Review

HNMT  -  histamine N-methyltransferase

Homo sapiens

Synonyms: HMT, HNMT-S1, HNMT-S2, Histamine N-methyltransferase
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Disease relevance of HNMT


Psychiatry related information on HNMT


High impact information on HNMT


Chemical compound and disease context of HNMT


Biological context of HNMT

  • In agreement with the predominant role of ABP1 versus HNMT on local histamine metabolism in human bowel, the frequencies for carriers of HNMT genotypes or mutated alleles were similar among patients, regardless clinical evolution, and control individuals [3].
  • Therefore, the level of HMT gene expression in human airway may be one of the critical factors determining the airway responsiveness to histamine [14].
  • In situ chromosomal hybridization demonstrated that human HMT gene was localized in chromosome 1 p32 [14].
  • These observations will make it possible to test the hypothesis that genetic polymorphisms for HNMT may play a role in the pathophysiology of human disease [15].
  • IC50 values for the HNMT inhibitor amodiaquine were 0.50, 0.48, and 0.40 microM, respectively, for enzyme from these same three sources [16].

Anatomical context of HNMT


Associations of HNMT with chemical compounds


Regulatory relationships of HNMT


Other interactions of HNMT


Analytical, diagnostic and therapeutic context of HNMT


  1. Histamine content, synthesis and degradation in human nasal mucosa. Abe, Y., Ogino, S., Irifune, M., Imamura, I., Fukui, H., Wada, H., Matsunaga, T. Clin. Exp. Allergy (1993) [Pubmed]
  2. Single nucleotide polymorphisms and haplotypes of histamine N-methyltransferase in patients with gastric ulcer. Chen, G.L., Zhu, B., Nie, W.P., Xu, Z.H., Tan, Z.R., Zhou, G., Liu, J., Wang, W., Zhou, H.H. Inflamm. Res. (2004) [Pubmed]
  3. Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene. García-Martin, E., Mendoza, J.L., Martínez, C., Taxonera, C., Urcelay, E., Ladero, J.M., de la Concha, E.G., Díaz-Rubio, M., Agúndez, J.A. World J. Gastroenterol. (2006) [Pubmed]
  4. Blood histamine concentrations are not elevated in humans with septic shock. Jacobs, R., Kaliner, M., Shelhamer, J.H., Parrillo, J.E. Crit. Care Med. (1989) [Pubmed]
  5. Histamine N-methyltransferase and diamine oxidase gene polymorphisms in patients with inflammatory and neoplastic intestinal diseases. Petersen, J., Raithel, M., Schwelberger, H.G. Inflamm. Res. (2002) [Pubmed]
  6. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. Horton, J.R., Sawada, K., Nishibori, M., Cheng, X. J. Mol. Biol. (2005) [Pubmed]
  7. Human erythrocyte histamine N-methyltransferase: radiochemical microassay and biochemical properties. Van Loon, J.A., Pazmiño, P.A., Weinshilboum, R.M. Clin. Chim. Acta (1985) [Pubmed]
  8. Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. Kim, S.H., Krapfenbauer, K., Cheon, M.S., Fountoulakis, M., Cairns, N.J., Lubec, G. Neurosci. Lett. (2002) [Pubmed]
  9. Processing of psoralen adducts in an active human gene: repair and replication of DNA containing monoadducts and interstrand cross-links. Vos, J.M., Hanawalt, P.C. Cell (1987) [Pubmed]
  10. Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Weinshilboum, R.M., Otterness, D.M., Szumlanski, C.L. Annu. Rev. Pharmacol. Toxicol. (1999) [Pubmed]
  11. Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. Mal, A.K. EMBO J. (2006) [Pubmed]
  12. Connecting the DOTs: covalent histone modifications and the formation of silent chromatin. Khan, A.U., Hampsey, M. Trends Genet. (2002) [Pubmed]
  13. Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain. Donatelli, P., Marchi, G., Giuliani, L., Gustafsson, L.L., Pacifici, G.M. Eur. J. Clin. Pharmacol. (1994) [Pubmed]
  14. Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. Yamauchi, K., Sekizawa, K., Suzuki, H., Nakazawa, H., Ohkawara, Y., Katayose, D., Ohtsu, H., Tamura, G., Shibahara, S., Takemura, M. Am. J. Physiol. (1994) [Pubmed]
  15. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. Preuss, C.V., Wood, T.C., Szumlanski, C.L., Raftogianis, R.B., Otterness, D.M., Girard, B., Scott, M.C., Weinshilboum, R.M. Mol. Pharmacol. (1998) [Pubmed]
  16. Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA. Girard, B., Otterness, D.M., Wood, T.C., Honchel, R., Wieben, E.D., Weinshilboum, R.M. Mol. Pharmacol. (1994) [Pubmed]
  17. Autonomous histamine metabolism in human melanoma cells. Darvas, Z., Sakurai, E., Schwelberger, H.G., Hegyesi, H., Rivera, E., Othsu, H., Watanabe, T., Pállinger, E., Falus, A. Melanoma Res. (2003) [Pubmed]
  18. Histamine content, synthesis and degradation in nasal mucosa and lung of guinea-pigs treated with toluene diisocyanate (TDI). Abe, Y., Ogino, S., Irifune, M., Imamura, I., Liu, Y.Q., Fukui, H., Matsunaga, T. Clin. Exp. Allergy (1993) [Pubmed]
  19. Putrescine metabolism and the study of diamine oxidase activity in vivo. Sourkes, T.L., Missala, K. Agents Actions (1981) [Pubmed]
  20. Vecuronium inhibits histamine N-methyltransferase. Futo, J., Kupferberg, J.P., Moss, J., Fahey, M.R., Cannon, J.E., Miller, R.D. Anesthesiology (1988) [Pubmed]
  21. Inhibition of histamine N-methyltransferase (HNMT) in vitro by neuromuscular relaxants. Futo, J., Kupferberg, J.P., Moss, J. Biochem. Pharmacol. (1990) [Pubmed]
  22. Interindividual variability of histamine N-methyltransferase in the human liver and kidney. De Santi, C., Donatelli, P., Giulianotti, P.C., Pietrabissa, A., Mosca, F., Pacifici, G.M. Xenobiotica (1998) [Pubmed]
  23. Metabolism and function of gastric histamine in health and disease. Lorenz, W., Thon, K., Barth, H., Neugebauer, E., Reimann, H.J., Kusche, J. J. Clin. Gastroenterol. (1983) [Pubmed]
  24. Hydroxyindole-O-methyltransferase (HIOMT), catechol-O-methyltransferase (COMT) and histamine-N-methyltransferase (HNMT) in the pineal gland of the vizcacha (Lagostomus maximus maximus). Guzmán, J.A., Pelzer, L.E., Piezzi, R.S., Scardapane, L., Dominguez, S. J. Neural Transm. (1980) [Pubmed]
  25. Expression of histidine decarboxylase messenger RNA and histamine N-methyltransferase messenger RNA in nasal allergy. Hirata, N., Takeuchi, K., Ukai, K., Sakakura, Y. Clin. Exp. Allergy (1999) [Pubmed]
  26. Association of THR105Ile, a functional polymorphism of histamine N-methyltransferase (HNMT), with alcoholism in German Caucasians. Reuter, M., Jeste, N., Klein, T., Hennig, J., Goldman, D., Enoch, M.A., Oroszi, G. Drug and alcohol dependence (2007) [Pubmed]
  27. Human histamine N-methyltransferase gene: structural characterization and chromosomal location. Aksoy, S., Raftogianis, R., Weinshilboum, R. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  28. A new radioenzymatic assay for histamine using purified histamine N-methyltransferase. Verburg, K.M., Bowsher, R.R., Henry, D.P. Life Sci. (1983) [Pubmed]
  29. Structure of M1 RNA as determined by psoralen cross-linking. Lipson, S.E., Cimino, G.D., Hearst, J.E. Biochemistry (1988) [Pubmed]
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