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Gene Review

Hnmt  -  histamine N-methyltransferase

Rattus norvegicus

Synonyms: HMT, Histamine N-methyltransferase
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Disease relevance of Hnmt


Psychiatry related information on Hnmt


High impact information on Hnmt


Biological context of Hnmt


Anatomical context of Hnmt


Associations of Hnmt with chemical compounds


Other interactions of Hnmt


Analytical, diagnostic and therapeutic context of Hnmt

  • Infusion of prostaglandin E2 (PGE2) into the third cerebroventricle increased the hypothalamic HA turnover rate, and simultaneously activated both HDC and HMT dose-dependently, but intravenous infusion of PGE2 had no effect on the dynamics of hypothalamic HA turnover [23].
  • A method for the determination of histamine N-methyltransferase (HMT) activity by high-performance liquid chromatography based on post-column derivatization with omicron-phthalaldehyde is described [24].
  • The intensity of the staining in western blotting correlated well with the enzyme activity in all the tissues in these three species, suggesting that our antiserum is useful for quantifying histamine N-methyltransferase protein in rodent tissues [25].
  • Northern blotting analysis indicated that the 1.6-kb guinea pig HMT transcript was expressed at various levels in different tissues at the following relative abundance: jejunum, brain > lung, spleen, stomach > liver, kidney [26].
  • We can conclude that DAO and HNMT activities in gut mucosa are reliable quantitative markers of acute intestinal allograft rejection in the rat that support histopathological analysis [27].


  1. Histamine N-methyltransferase from rat kidney. Cloning, nucleotide sequence, and expression in Escherichia coli cells. Takemura, M., Tanaka, T., Taguchi, Y., Imamura, I., Mizuguchi, H., Kuroda, M., Fukui, H., Yamatodani, A., Wada, H. J. Biol. Chem. (1992) [Pubmed]
  2. Peroxidation-induced changes of histamine metabolism and transport of its precursor histidine in rat brain synaptosomes. Rafałowska, U., Wałajtys-Rode, E. Free Radic. Biol. Med. (1991) [Pubmed]
  3. The effect of intrahypothalamic injection of homodimaprit on blood pressure. Gatti, P.J., Gertner, S.B. Neuropharmacology (1984) [Pubmed]
  4. Endogenous central histamine-induced reversal of critical hemorrhagic hypotension in rats: studies with L-histidine. Jochem, J. Shock (2003) [Pubmed]
  5. Histamine, histidine decarboxylase and histamine-N-methyltransferase in brain areas of spontaneously hypertensive rats. Prast, H., Gujrati, V., Walser, S., Philippu, A. Naunyn Schmiedebergs Arch. Pharmacol. (1988) [Pubmed]
  6. Effect of electroconvulsive shock (ECS) treatment on the histaminergic system in rat brain: biochemical and behavioural studies. Zawilska, J., Nowak, J.Z. Agents Actions (1986) [Pubmed]
  7. Maternally transmitted antigen of mice: a model transplantation antigen. Fischer Lindahl, K., Hermel, E., Loveland, B.E., Wang, C.R. Annu. Rev. Immunol. (1991) [Pubmed]
  8. Reduction of N-nitroso-N-ethylurea-induced neurogenic tumors by X-radiation: a life-span study in rats. Knowles, J.F. J. Natl. Cancer Inst. (1984) [Pubmed]
  9. Rat histamine N-methyltransferase. Quantification, tissue distribution, purification, and immunologic properties. Bowsher, R.R., Verburg, K.M., Henry, D.P. J. Biol. Chem. (1983) [Pubmed]
  10. Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Horton, J.R., Sawada, K., Nishibori, M., Zhang, X., Cheng, X. Structure (Camb.) (2001) [Pubmed]
  11. Hypothalamic 24-hour rhythms in histamine, histidine, decarboxylase and histamine-N-methyltransferase. Orr, E., Quay, W.B. Endocrinology (1975) [Pubmed]
  12. Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain. Hough, L.B., Jackowski, S., Eberle, N., Gogas, K.R., Camarota, N.A., Cue, D. Biochem. Pharmacol. (1988) [Pubmed]
  13. Inhibition of histamine-N-methyltransferase (HNMT) by fragments of 9-amino-1,2,3,4-tetrahydroacridine (tacrine) and by beta-carbolines. Cumming, P., Vincent, S.R. Biochem. Pharmacol. (1992) [Pubmed]
  14. Inhibitors of histamine methylation in brain promote formation of imidazoleacetic acid, which interacts with GABA receptors. Prell, G.D., Morrishow, A.M., Duoyon, E., Lee, W.S. J. Neurochem. (1997) [Pubmed]
  15. Effect of cocaine on the histaminergic neuron system in the rat brain. Ito, C., Onodera, K., Sakurai, E., Sato, M., Watanabe, T. J. Neurochem. (1997) [Pubmed]
  16. Presence of histamine and histamine-metabolizing enzyme in rat and guinea-pig microvascular endothelial cells. Robinson-White, A., Beaven, M.A. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  17. Is neurotransmitter histamine predominantly inactivated in astrocytes? Rafałowska, U., Waśkiewicz, J., Albrecht, J. Neurosci. Lett. (1987) [Pubmed]
  18. Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism. da Silva, W.C., Bonini, J.S., Bevilaqua, L.R., Izquierdo, I., Cammarota, M. Neurobiology of learning and memory. (2006) [Pubmed]
  19. Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine. Houston, D.M., Matuszewska, B., Borchardt, R.T. J. Med. Chem. (1985) [Pubmed]
  20. Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies. Garbarg, M., Barbin, G., Rodergas, E., Schwartz, J.C. J. Neurochem. (1980) [Pubmed]
  21. Change of hepatic histamine content during hepatic fibrosis. Umezu, K., Yuasa, S., Sudoh, A. Biochem. Pharmacol. (1985) [Pubmed]
  22. Ontogenetic development of a 5-methyltetrahydrofolate requiring enzyme in rats and mice. Laduron, P., Janssen, P.F., Aerts, G., Leysen, J. Naunyn Schmiedebergs Arch. Pharmacol. (1975) [Pubmed]
  23. Prostaglandin E2 mediates activation of hypothalamic histamine by interleukin-1beta in rats. Kang, M., Yoshimatsu, H., Kurokawa, M., Ogawa, R., Sakata, T. Proc. Soc. Exp. Biol. Med. (1999) [Pubmed]
  24. High-performance liquid chromatographic determination of histamine N-methyltransferase activity. Fukuda, H., Yamatodani, A., Imamura, I., Maeyama, K., Watanabe, T., Wada, H. J. Chromatogr. (1991) [Pubmed]
  25. Tissue distribution of histamine N-methyltransferase-like immunoreactivity in rodents. Takemura, M., Imamura, I., Mizuguchi, H., Fukui, H., Yamatodani, A. Life Sci. (1994) [Pubmed]
  26. Guinea pig histamine N-methyltransferase: cDNA cloning and mRNA distribution. Kitanaka, J., Kitanaka, N., Tsujimura, T., Kakihana, M., Terada, N., Takemura, M. Jpn. J. Pharmacol. (2001) [Pubmed]
  27. Histamine-degrading enzymes as cellular markers of acute small bowel allograft rejection. Klaus, A., Weiss, H., Nguyen, J.H., Margreiter, R., Obrist, P., Schwelberger, H.G. Transpl. Int. (2003) [Pubmed]
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