Disease relevance of 4-Methylhistamine

• The effects of H2-blocking agents and the H2 receptor agonist, 4-methylhistamine, on the severity of anaphylactic reactions were studied in the guinea pig in vivo [1].
• H+ and pepsin output were studied in four gastric fistula dogs with histamine and in five dogs with 4-methylhistamine (4(Me)H), an H2 histamine receptor agonist with little H1 effect [2].

Psychiatry related information on 4-Methylhistamine

• 2-Pyridylethylamine (2-PEA) and 4-methylhistamine (4-MeHI) when given intraventricularly at doses of 30 and 100 microgram had no discernible effect on spontaneous locomotor activity and did not visibly change gross behavior of rats [3].

High impact information on 4-Methylhistamine

• The H2 receptor agonist 4-methylhistamine caused a reduction of LES tension and EB off response amplitude, but caused an increase in those parameters in the presence of metiamide [4].
• (4) Contractions caused by electric stimulation were inhibited by an H2-receptor agonist (4-methylhistamine) and augmented by an H1-receptor agonist (2-methylhistamine) [5].
• The EC50 values of histamine, 4-methylhistamine, and dimaprit for the production of IL-18 were 1.5, 1.0, and 3.8 microM, respectively [6].
• It was found that histamine and 4-methylhistamine increased the number of granulocyte colony-forming units in murine bone marrow cells [7].
• Similar observations were also made with other thyroid stimulators, such as prostaglandin E2 and 4-methylhistamine [8].

Chemical compound and disease context of 4-Methylhistamine

• Dimaprit and 4-methylhistamine increased locomotor activity in tranylcypromine-treated rats [9].

Biological context of 4-Methylhistamine

• Proceedings: Effects of histamine, 2-methylhistamine and 4-methylhistamine on blood pressure and vascular resistance in the cat [10].
• Larger doses of 4-methylhistamine also lower blood pressure but this may involve H1-receptors [11].
• A histamine H2-receptor agonist, 4-methylhistamine, triggers the pluripotent stem cells of mouse bone marrow from a noncycling state into the DNA synthetic phase of the cell cycle [12].
• 3 Intra-arterial 4-methylhistamine, an H2-receptor agonist, caused vasodilatation which was reduced by metiamide [13].
• The influence of 4-methylhistamine, an agonist of histamine H2 receptors on body temperature in rats [14].

Anatomical context of 4-Methylhistamine

• Selectivity of 4-methylhistamine at H1- and H2-receptors in the guinea-pig isolated ileum [15].
• Histamine and 4-methylhistamine had a positive chromnotropic effect on right atria and a positive inotropic effect on right ventricle strips [16].
• Histamine and 4-methylhistamine inhibited ganglionic transmission in the rat superior cervical ganglion in vitro via H2-histaminergic receptors [17].
• 2 In anaesthetized dogs, the H1-receptor agonist, 2-pyridylethylamine (0.05 to 15 mumol, i.a.), elicited dose-dependent increases in cystic duct resistance, whereas the H2-receptor agonist, 4-methylhistamine (0.05 to 15 mumol, i.a.) decreased cystic duct resistance [18].
• Using quantitative cytochemistry of CA activity in guinea-pig oxyntic cells, we compared the dose-response relationships (1.0 X 10(-17)-1.0 X 10(-9) M) of specific H2 (dimaprit, 4-methylhistamine, impromidine) and H1 (2-pyridylethylamine) agonists with histamine (H1 and H2) [19].

Associations of 4-Methylhistamine with other chemical compounds

• Selective H2 receptor agonists, 4-methylhistamine and dimaprit, mimicked the effects of histamine on five kinds of cytokine production [6].
• Cimetidine (an H2 antagonist) had no significant direct effects on the sinus rate or atrioventricular conduction and failed to prevent the acceleration of the sinus rate produced by local perfusion with 4-methylhistamine [20].
• Central administration of HA, the H1-receptor agonist 2-thiazolylethylamine (2-TEA) or the H2-receptor agonist 4-methylhistamine (4-MeHA) stimulated the secretion of ACTH, beta-END, alpha-MSH and PRL [21].
• Ranitidine was able to prevent the prolactin response to 4-methylhistamine [22].
• Intraventricular administration of 500 microgram of 2-pyridylethylamine, an agonist of the histamine (Hi) H1-receptor, produced a 20% increase of striatal HVA in the rat while the Hi H2-receptor agonist 4-methylhistamine had no influence on HVA and DOPAC levels [23].

Gene context of 4-Methylhistamine

• The effects of selective H2-receptor agonists, 4-methylhistamine and dimaprit, on CD14 expression mimicked that of histamine indicating that histamine regulated CD14 expression through the stimulation of H2-receptors [24].
• Intracerebroventricular infusion of HA (270 nmol), the H1-receptor agonist 2-thiazolylethylamine or the H2-receptor agonist 4-methylhistamine increased the level of CRH mRNA in the PVN, and OT mRNA in the SON [25].
• Intracerebroventricular administration of the H1 receptor agonist 2-thiazolylethylamine (2-TEA) or the H2 receptor agonist 4-methylhistamine (4-MeHA) increased the CRH concentration in pituitary portal blood by 80-90% when compared to preinfusion levels (p < 0.05) [26].
• Histamine, 2-pyridylethylamine (PEA), a histamine H1-receptor agonist, and 4-methylhistamine (MeHA) and dimaprit, H2-receptor agonists, significantly intensified the stress-induced increase in serum corticosterone levels [27].
• Pretreatment with 4-methylhistamine, a histamine H2-receptor agonist, did not alter the antinociceptive activity of morphine or the antagonistic effect of naloxone [28].

Analytical, diagnostic and therapeutic context of 4-Methylhistamine

• The effect of 4-methylhistamine also was reduced by reserpine or adrenalectomy [29].
• Continuous intravenous infusion of metiamide, which is a histamine H2-receptor blocker, to the mepyramine treated cats caused a further inhibition in response to histamine as well as 4-methylhistamine [30].

References