The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Neoprene     2-chlorobuta-1,3-diene

Synonyms: Cloroprene, CHLOROPRENE, Chloropreen, CCRIS 873, CHEMBL555660, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neoprene


Psychiatry related information on Neoprene


High impact information on Neoprene


Chemical compound and disease context of Neoprene


Biological context of Neoprene


Anatomical context of Neoprene

  • Following 2 years of inhalation exposure to 12.8, 32 or 80 p.p.m. chloroprene, increased incidences of lung and Harderian gland (HG) neoplasms were observed in B6C3F1 mice at all exposure concentrations [11].
  • Cancer potency of chloroprene is greater in the mouse lung than in the rat lung, but greater in the rat kidney than in the mouse kidney and nearly equivalent in the mammary gland of each species [2].
  • In incubations of chloroprene with liver microsomes containing GSH, several GSH conjugates were identified [20].
  • Isoprene induced both SCE and micronuclei, whereas chloroprene gave negative results for all cytogenetic end points assessed in bone marrow cells [18].
  • NADPH in microsomes reduces the hydroxocob(III)alamin form of vitamin B12 to cob(II)alamin and the supernucleophilic cob(I)alamin, which are both highly reactive toward xenobiotic epoxides formed by mammalian metabolism of dienes such as the industrially important chemicals chloroprene and 1,3-butadiene [21].

Associations of Neoprene with other chemical compounds


Gene context of Neoprene

  • DNA damage is suppressed in the presence of glutathione (GSH), catalase or superoxide dismutase. b) Chloroprene is mutagenic in Salmonella typhimurium but not carcinogenic, possibly due to inactivation by GSH-conjugations. c) Chlorodinitrobenzene is not mutagenic is Salmonella typhimurium in the presence of GSH [26].
  • Subjects are sealed in a LBNP chamber with the use of a flexible, neoprene waist seal and the chamber pressure is reduced to provide an increased vertical force [27].
  • Nine healthy males wearing neoprene wet suits (5 mm thick) were subjected to immersion to the neck in water at 1, 2, and 2.5 ATA while resting for 3 h [28].
  • Chloroprene (2-chloro-1,3-butadiene, 1) is oxidised by cytochrome P450 enzymes in mammalian liver microsomes to several metabolites, some of which are reactive towards DNA and are mutagenic [29].
  • The mean recoveries of methenamine hippurate from spiked test plates for '180 Grit' Stainless Steel, Teflon and WARCO White (neoprene and PVC) gasket material were 77.2, 96.1 and 50.6%, with RSDs of +/- 9.4 (n = 25), +/- 4.3 (n = 25) and +/- 36% (n = 20), respectively [30].

Analytical, diagnostic and therapeutic context of Neoprene


  1. Endocrine responses of type 1 (insulin-dependent) diabetic patients following successful pancreas transplantation. Pozza, G., Traeger, J., Dubernard, J.M., Secchi, A., Pontiroli, A.E., Bosi, E., Malik, M.C., Ruitton, A., Blanc, N. Diabetologia (1983) [Pubmed]
  2. Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice. Melnick, R.L., Sills, R.C., Portier, C.J., Roycroft, J.H., Chou, B.J., Grumbein, S.L., Miller, R.A. Carcinogenesis (1999) [Pubmed]
  3. Endocrinometabolic effects of whole versus segmental pancreas allotransplantation in diabetic patients--a two-year follow-up. Secchi, A., Dubernard, J.M., La Rocca, E., LeFrancois, N., Melandri, M., Martin, X., Touraine, J.L., Traeger, J., Pozza, G. Transplantation (1991) [Pubmed]
  4. Toxicity of chloroprene, 1,3-dichlorobutene-2, and 1,4-dichlorobutene-2. Clary, J.J. Environ. Health Perspect. (1977) [Pubmed]
  5. The effect of anterior cruciate ligament trauma and bracing on knee proprioception. Beynnon, B.D., Ryder, S.H., Konradsen, L., Johnson, R.J., Johnson, K., Renström, P.A. The American journal of sports medicine. (1999) [Pubmed]
  6. Effect of a neoprene sleeve on knee joint kinesthesis: influence of different testing procedures. Birmingham, T.B., Inglis, J.T., Kramer, J.F., Vandervoort, A.A. Medicine and science in sports and exercise. (2000) [Pubmed]
  7. The use of a neoprene "thumb-sock" to prevent trauma in a thumb-sucking child with intractable epilepsy. Dennison, P.J., Walton-Jones, A. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. (1999) [Pubmed]
  8. Pancreatoduodenectomy with neoprene occlusion of main pancreatic duct. Rovati, V., Brigante, G., Bevilacqua, M., Milanesi, A. Lancet (1984) [Pubmed]
  9. Impact of immunosuppression on improvement of results in clinical pancreas transplantation. Melandri, M., Dubernard, J.M., Sanseverino, R., Camozzi, L., LeFrancois, N., Faure, J.L., Martin, X., La Rocca, E., Gelet, A., Touraine, J.L. Diabetes (1989) [Pubmed]
  10. Islet cell autoimmunity in type I diabetic patients after HLA-mismatched pancreas transplantation. Bosi, E., Bottazzo, G.F., Secchi, A., Pozza, G., Shattock, M., Saunders, A., Gelet, A., Touraine, J.L., Traeger, J., Dubernard, J.M. Diabetes (1989) [Pubmed]
  11. High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene. Sills, R.C., Hong, H.L., Melnick, R.L., Boorman, G.A., Devereux, T.R. Carcinogenesis (1999) [Pubmed]
  12. Toxicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344 rats and B6C3F(1) mice. Melnick, R.L., Elwell, M.R., Roycroft, J.H., Chou, B.J., Ragan, H.A., Miller, R.A. Toxicology (1996) [Pubmed]
  13. Mortality patterns among industrial workers exposed to chloroprene and other substances I. General mortality patterns. Marsh, G.M., Youk, A.O., Buchanich, J.M., Cunningham, M., Esmen, N.A., Hall, T.A., Phillips, M.L. Chem. Biol. Interact. (2007) [Pubmed]
  14. Mortality patterns among industrial workers exposed to chloroprene and other substances II. Mortality in relation to exposure. Marsh, G.M., Youk, A.O., Buchanich, J.M., Cunningham, M., Esmen, N.A., Hall, T.A., Phillips, M.L. Chem. Biol. Interact. (2007) [Pubmed]
  15. Allergic contact dermatitis due to diphenylthiourea in a neoprene slimming suit. Alcántara, M., Martínez-Escribano, J., Frías, J., García-Sellés, F.J. Contact Derm. (2000) [Pubmed]
  16. Allergic contact dermatitis to thiourea in a neoprene knee brace. Sakata, S., Cahill, J., Nixon, R. Australas. J. Dermatol. (2006) [Pubmed]
  17. Aspects of the toxicology of chloroprene: immediate and long-term effects. Sanotskii, I.V. Environ. Health Perspect. (1976) [Pubmed]
  18. Results of NTP-sponsored mouse cytogenetic studies on 1,3-butadiene, isoprene, and chloroprene. Shelby, M.D. Environ. Health Perspect. (1990) [Pubmed]
  19. Identification of adducts derived from reactions of (1-chloroethenyl)oxirane with nucleosides and calf thymus DNA. Munter, T., Cottrell, L., Hill, S., Kronberg, L., Watson, W.P., Golding, B.T. Chem. Res. Toxicol. (2002) [Pubmed]
  20. Detoxication pathways involving glutathione and epoxide hydrolase in the in vitro metabolism of chloroprene. Munter, T., Cottrell, L., Golding, B.T., Watson, W.P. Chem. Res. Toxicol. (2003) [Pubmed]
  21. A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics. Watson, W.P., Munter, T., Golding, B.T. Chem. Res. Toxicol. (2004) [Pubmed]
  22. Mutagenicity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells. Drevon, C., Kuroki, T. Mutat. Res. (1979) [Pubmed]
  23. Mutagenicity of chloroprene, 1-chloro-1,3-trans-butadiene, 1-4-dichlorobutene-2 and 1,4-dichloro-2,3-epoxybutane in Drosophila melanogaster. Vogel, E. Mutat. Res. (1979) [Pubmed]
  24. Evaluation of techniques of controlling exocrine drainage after segmental pancreatectomy in dogs. Implications for pancreatic transplantation. Nghiem, D.D., Pitzen, R.H., Corry, R.J. Archives of surgery (Chicago, Ill. : 1960) (1985) [Pubmed]
  25. A comparison of ductal management techniques in an in situ canine pancreas model. Garvin, P.J., Castaneda, M., Codd, J.E., Pennell, R., Niehoff, M. Archives of surgery (Chicago, Ill. : 1960) (1984) [Pubmed]
  26. Threshold levels in toxicology: significance of inactivation mechanisms. Greim, H., Andrae, U., Göggelmann, W., Hesse, S., Schwarz, L.R., Summer, K.H. Adv. Exp. Med. Biol. (1981) [Pubmed]
  27. Simulated hypergravity running increases skeletal and cardiovascular loads. Groppo, E.R., Eastlack, R.K., Mahar, A., Hargens, A.R., Pedowitz, R.A. Medicine and science in sports and exercise. (2005) [Pubmed]
  28. Effect of pressure on thermal insulation in humans wearing wet suits. Park, Y.H., Iwamoto, J., Tajima, F., Miki, K., Park, Y.S., Shiraki, K. J. Appl. Physiol. (1988) [Pubmed]
  29. The metabolism and molecular toxicology of chloroprene. Munter, T., Cottrell, L., Ghai, R., Golding, B.T., Watson, W.P. Chem. Biol. Interact. (2007) [Pubmed]
  30. Capillary gas chromatographic assay of residual methenamine hippurate in equipment cleaning validation swabs. Mirza, T., George, R.C., Bodenmiller, J.R., Belanich, S.A. Journal of pharmaceutical and biomedical analysis. (1998) [Pubmed]
  31. Segmental duct-obstructed pancreas grafts versus pancreaticoduodenal grafts with enteric diversion. Martin, X., Dubernard, J.M., Sanseverino, R., Melandri, M., Faure, J.L., Camozzi, L., LeFrancois, N., La Rocca, E., Gelet, A. Diabetes (1989) [Pubmed]
  32. The effect of bracing on varus gonarthrosis. Kirkley, A., Webster-Bogaert, S., Litchfield, R., Amendola, A., MacDonald, S., McCalden, R., Fowler, P. The Journal of bone and joint surgery. American volume. (1999) [Pubmed]
  33. Growth, liver lipid and blood amino acids in rats fed ethanol with an adequate diet. Shoemaker, J.D., Visek, W.J. Drug and alcohol dependence. (1988) [Pubmed]
  34. Cohort studies of chloroprene-exposed workers in Russia. Zaridze, D., Bulbulyan, M., Changuina, O., Margaryan, A., Boffetta, P. Chem. Biol. Interact. (2001) [Pubmed]
  35. Clinical implications of the velopharyngeal blood supply: a fresh cadaveric study. Huang, M.H., Lee, S.T., Rajendran, K. Plast. Reconstr. Surg. (1998) [Pubmed]
WikiGenes - Universities