Disease relevance of PGE

• [3H]B(a)P, in a vehicle of triethylene glycol, was administered by intratracheal instillation (1 microgram/kg body weight), and the amount of radioactivity in various organs was determined at timed intervals between 5 and 360 min [1].
• Fluorescence quenching has been used to measure quantitatively the effects of sucrose and triethylene glycol on the interaction between the Escherichia coli regulatory protein TyrR and a 30-basepair oligonucleotide containing the strong TyrR box of the TyrR operon [2].
• Developmental toxicity study with triethylene glycol given by gavage to CD rats and CD-1 mice [3].

High impact information on PGE

• Under physiological conditions (150 mM NaCl, 2 mM MgCl2, pH 7.4), incorporation of a single allofuranosyl cytosine substituted with a triethyleneglycol moiety led to a significant enthalpic stabilization of an A-type RNA duplex [4].
• This study tested the hypothesis that the release of chlorhexidine from a urethane dimethacrylate and triethylene glycol dimethacrylate resin system can be effectively controlled by the chlorhexidine diacetate content and pH [5].
• Ruthenium(II) bis(terpyridine) complexes have been prepared with two triethylene glycol linkers to which DNA sequences have been attached; hybridization at various complex ratios results in linear arrays of varying lengths [6].
• In this preliminary investigation, DSC was used to ascertain the degree of vinyl polymerization of an experimental monomer system consisting of seven parts BIS-GMA and three parts TEGDMA (triethylene glycol dimethacrylate) [7].
• The metabolic products formed from TEG by intact cells were isolated and identified by combined gas chromatography-mass spectrometry as triethylene glycol and TEG-monocarboxylic acid plus small amounts of TEG-dicarboxylic acid, diethylene glycol, and ethylene glycol [8].

Chemical compound and disease context of PGE

• Reproductive toxicity of triethylene glycol and its diacetate and dimethyl ether derivatives in a continuous breeding protocol in Swiss CD-1 mice [9].

Biological context of PGE

• The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells [10].
• The experimental results indicate that these dimers, especially the triethylene glycol-bridged fMLP dimer, D-fMLP-G3, are selective agonists for chemotaxis [11].
• INTERVENTION: All patients were treated in the supine position with a TAN nail (Trigen System, Smith & Nephew, Memphis, TN) inserted through the greater trochanter [12].
• The current study determined the long-term effects of sub-lethal concentrations of TEGDMA (triethyleneglycol dimethacrylate) and Bis-GMA (bisphenol-glycidylinethacrylate), two common dental monomers, on the in vitro cellular proliferation, succinic dehydrogenase activity, and total cellular protein production of monocytes [13].
• CASE REPORT: A 23-year-old female presented to the emergency department approximately 1-1.5 hours following ingestion of a gulp of triethylene glycol (99%) brake fluid with coma (GCS-3) and metabolic acidemia (pH 7.03, PCO2 44 mm Hg, Bicarbonate 11 mmol/L, anion gap 30 mmol/L, serum creatinine 90 mumol/L) [14].

Anatomical context of PGE

• Among the analyzed polymers, the poly(vinyl alcohol)-co-oleylvinyl ether substituted with triethylene glycol monoethyl ether (P10(4)) provided in solution the highest affinity for hydrophobic membranes [15].

Associations of PGE with other chemical compounds

• Bacterial growth rates were measured at 37 degrees C, and pH values of 5.5 (representative of cariogenic state) or 7.0 at concentrations of 0-50mmol/l for MA (Sigma, US) and 0-100mmol/l for TEG (Sigma, US) [16].
• The in situ temperatures at the sampling sites ranged from 37 to 45 degrees C. Investigations focussed on sulfate-reducing bacteria able to grow on methanol and triethylene glycol, which are added as chemicals to facilitate the long-term underground storage of natural gas [17].
• A prospective study to assess the effects of triethylene glycol diglyceridyl ether (Epodyl) in the management of superficial noninvasive vesical neoplasm (T1) is presented [18].
• The 3 most common sensitizers were ethyleneglycol dimethacrylate (17 positive patch tests), 2-hydroxyethyl methacrylate (14) and triethyleneglycol dimethacrylate (6) [19].
• When chrysotile asbestos was intratracheally instilled 24 h prior to instillation of [3H]B[a]P dissolved in triethylene glycol, the rate of excretion of radioactivity was slower than without asbestos pretreatment, with only 61.8% of the dose appearing in bile in 6 h [20].

Gene context of PGE

• Triethylene glycol dimethacrylate induces large deletions in the hprt gene of V79 cells [21].
• It was found that at pH 5.5 TEG significantly stimulated the growth of both S. mutans strains ( p<0.05 ) in the concentration range of 0.5-10.0mmol/l and stimulated the growth of S. salivarius AT2 for the entire concentration range tested (p<0.05) [16].
• Three of them were obtained with methanol (strains H1M, H3M, and B1M), three strains with triethylene glycol (strains H1T, B1T, and B2T) and one strain with a mixture of lactate, acetate and butyrate (strain H1-13) [17].
• CONCLUSION: Pure triethylene glycol poisoning results in coma and metabolic acidemia and may be treated with alcohol dehydrogenase inhibitors such as ethanol [14].
• The potential for adverse effects from exposure to respirable aerosols of triethylene glycol (TEG: CAS Number 112-27-6) was investigated by a peripheral chemosensory irritation study, and by acute and repeated exposure toxicity studies [22].

Analytical, diagnostic and therapeutic context of PGE

• Binding properties of the tricationic porphyrin monomer with a phenolic substituent at the periphery and the porphyrin dimer conjugated with hydrophilic triethylene glycol were investigated in this study using absorption and polarized spectroscopy, namely, circular dichroism (CD) and linear dichroism (LD) [23].
• The performance of a newly synthesized carbosilane dendrimer bearing four triethylene glycol ether (TEG) units, Si(CH(2)CH(2)CH(2)Si(Me)(2)CH(2)CH(2)CH(2)(OCH(2)CH(2))(3)Me)(4) (1), as ionophores in ion-selective electrodes has been investigated [24].
• The authors used high-pressure liquid chromatography to analyze the amount of monomers--bisphenol A glycidyl dimethacrylate, or Bis-GMA; triethylene glycol dimethacrylate, or TEGDMA; and bisphenol A dimethacrylate, or Bis-DMA--remaining after each treatment [25].
• Gas chromatography/electron impact mass spectrometry, fast atom bombardment mass spectrometry, mass-analyzed ion kinetic energy spectroscopy and B/E linked scan analysis of triaryl phosphates and triethylene glycol fatty acid esters [26].
• Bovine serum albumin or bovine serum albumin covalently linked to deoxycholic acid and triethylene glycol glutarate were used for the preparation of microspheres loaded with indomethacin [27].

References