Chemical Compound Review:
Melatonan (3S,6S,9R,12S,15S,23S)-15- [[(2S)-2...
Synonyms:
MT-II, Melanotan-II, D-Phe7, Asp5, Melanotan II, ...
Drazen,
Wortman,
Schwartz,
Clegg,
van Dijk,
Woods,
Seeley,
van Dijk,
de Vries,
Nyakas,
Buwalda,
Adage,
Kuipers,
Kas,
Adan,
Wilkinson,
Thiele,
Scheurink,
Watanobe,
Yoneda,
Hadley,
Dorr,
Giuliano,
Rössler,
Clément,
Droupy,
Alexandre,
Bernabé,
Giuliano,
Clément,
Droupy,
Alexandre,
Bernabé,
Heijboer,
van den Hoek,
Pijl,
Voshol,
Havekes,
Romijn,
Corssmit,
- Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice. Heijboer, A.C., van den Hoek, A.M., Pijl, H., Voshol, P.J., Havekes, L.M., Romijn, J.A., Corssmit, E.P. Diabetologia (2005)
- Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats. van Dijk, G., de Vries, K., Nyakas, C., Buwalda, B., Adage, T., Kuipers, F., Kas, M.J., Adan, R.A., Wilkinson, C.W., Thiele, T.E., Scheurink, A.J. Endocrinology (2005)
- Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide. Lan, E.L., Ugwu, S.O., Blanchard, J., Fang, X., Hruby, V.J., Sharma, S. Journal of pharmaceutical sciences. (1994)
- The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Rössler, A.S., Pfaus, J.G., Kia, H.K., Bernabé, J., Alexandre, L., Giuliano, F. Pharmacol. Biochem. Behav. (2006)
- Melanocortin 4 receptor-mediated hyperphagia and activation of neuropeptide Y expression in the dorsomedial hypothalamus during lactation. Chen, P., Williams, S.M., Grove, K.L., Smith, M.S. J. Neurosci. (2004)
- Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. Wessells, H., Fuciarelli, K., Hansen, J., Hadley, M.E., Hruby, V.J., Dorr, R., Levine, N. J. Urol. (1998)
- Adrenalectomy alters the sensitivity of the central nervous system melanocortin system. Drazen, D.L., Wortman, M.D., Schwartz, M.W., Clegg, D.J., van Dijk, G., Woods, S.C., Seeley, R.J. Diabetes (2003)
- Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Sutton, G.M., Duos, B., Patterson, L.M., Berthoud, H.R. Endocrinology (2005)
- Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. Giuliano, F., Clément, P., Droupy, S., Alexandre, L., Bernabé, J. Neuroscience (2006)
- The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Ter Laak, M.P., Brakkee, J.H., Adan, R.A., Hamers, F.P., Gispen, W.H. Eur. J. Pharmacol. (2003)
- Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue. Song, C.K., Jackson, R.M., Harris, R.B., Richard, D., Bartness, T.J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005)
- Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections. Zheng, H., Patterson, L.M., Phifer, C.B., Berthoud, H.R. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005)
- Melanocortin receptor signaling in RAW264.7 macrophage cell line. Lam, C.W., Perretti, M., Getting, S.J. Peptides (2006)
- MTII administered peripherally reduces fat without invoking apoptosis in rats. Choi, Y.H., Li, C., Hartzell, D.L., Lin, J., Della-Fera, M.A., Baile, C.A. Physiol. Behav. (2003)
- The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Banno, R., Arima, H., Sato, I., Hayashi, M., Goto, M., Sugimura, Y., Murase, T., Oiso, Y. Peptides (2004)
- The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. Raposinho, P.D., White, R.B., Aubert, M.L. J. Neuroendocrinol. (2003)
- Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats. Watanobe, H., Yoneda, M. Neuroendocrinology (2003)
- The use of telemetry technology to test the proerectile effect of melanotan-II (MT-II) in conscious rats. Giuliano, F., Rössler, A.S., Clément, P., Droupy, S., Alexandre, L., Bernabé, J. Eur. Urol. (2005)
- Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Hadley, M.E., Dorr, R.T. Peptides (2006)
- Determination of melanotan-II in rat plasma by liquid chromatography/tandem mass spectrometry: determination of pharmacokinetic parameters in rat following intravenous administration. Mock, S., Shen, X., Tamvakopoulos, C. Rapid Commun. Mass Spectrom. (2002)
- High-performance liquid chromatographic assay for the alpha-melanotropin[4,10] fragment analogue (Melanotan-II) in rat plasma. Ugwu, S.O., Blanchard, J. J. Chromatogr. (1992)
- Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Wessells, H., Gralnek, D., Dorr, R., Hruby, V.J., Hadley, M.E., Levine, N. Urology (2000)