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Disease relevance of Lordosis


Psychiatry related information on Lordosis


High impact information on Lordosis


Chemical compound and disease context of Lordosis


Biological context of Lordosis

  • Finally, females lacking a functional beta isoform of the ER gene showed normal lordosis and courtship behaviors, extending in some cases beyond the day of behavioral estrus [18].
  • Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: a review [19].
  • In adulthood, feminine sexual behavior (lordosis) was tested after E2 plus progesterone priming [20].
  • However, TP but not DHTP masculinized the development of the regulation of GTH release as mesured by luteinization of subcutaneous ovarian grafts, and also suppressed the ability of adult neonatally castrated male primed with estradiol benzoate and progesterone to display lordosis behavior [21].
  • To evaluate the interactions between OXY and NE in the regulation of reproductive behavior, lordosis responses were observed in hormone-primed female rats receiving systemic injections of OXY, the alpha 1-adrenoceptor antagonist prazosin, or both OXY and prazosin.(ABSTRACT TRUNCATED AT 250 WORDS)[22]

Anatomical context of Lordosis


Gene context of Lordosis

  • EGF and EGF receptor ligands induced lordosis in a dose- and time-dependent manner in the absence of steroid treatment in ovariectomized rats and mice [26].
  • We demonstrate that NPY inhibits lordosis duration in a dose-related fashion after lateral ventricular injection in ovariectomized, steroid-primed Syrian hamsters [27].
  • Under the same conditions, we compared the effect of two receptor-differentiating agonists derived from peptide YY (PYY), PYY-(3-36) and [Leu(31),Pro(34)]PYY, on lordosis duration and food intake [27].
  • We now report that intracerebroventricular (ICV) injections of OXY enhance lordosis behavior in OVXed estrogen-treated rats [28].
  • Cholecystokinin (CCK) acting on discrete receptors in the limbic-hypothalamic circuit modulates lordosis behavior [29].

Analytical, diagnostic and therapeutic context of Lordosis


  1. Familial neuromuscular disease with type 1 fiber hypoplasia, tubular aggregates, cardiomyopathy, and myasthenic features. Dobkin, B.H., Verity, M.A. Neurology (1978) [Pubmed]
  2. GABA(A) receptor regulation of kyphotic nursing and female sexual behavior in the caudal ventrolateral periaqueductal gray of postpartum rats. Salzberg, H.C., Lonstein, J.S., Stern, J.M. Neuroscience (2002) [Pubmed]
  3. Effects of serotonin agonists on lordosis, myoclonus, and cytoplasmic progestin receptors in guinea pigs. O'Connor, L.H., Feder, H.H. Hormones and behavior. (1983) [Pubmed]
  4. The possibility of creating lordosis and correcting scoliosis simultaneously after partial disc removal. Balance lines of lumbar motion segments. Ogon, M., Haid, C., Krismer, M., Jesenko, R., Wimmer, C. Spine. (1996) [Pubmed]
  5. Alterations by estrogen and hypothyroidism in the effects of septal lesions on lordosis behavior of male rats. Nance, D.M., Phelps, C., Shryne, J.E., Gorski, R.A. Brain Res. Bull. (1977) [Pubmed]
  6. Effects of pregnancy hormones on maternal responsiveness, responsiveness to estrogen stimulation of maternal behavior, and the lordosis response to estrogen stimulation. Rosenblatt, J.S., Olufowobi, A., Siegel, H.I. Hormones and behavior. (1998) [Pubmed]
  7. Acute fasting decreases sexual receptivity and neural estrogen receptor-alpha in female rats. Jones, J.E., Wade, G.N. Physiol. Behav. (2002) [Pubmed]
  8. Lordosis behavior and mounting behavior in male rats: effects of castration and treatment with estradiol benzoate or testosterone propionate. Södersten, P., Larsson, K. Physiol. Behav. (1975) [Pubmed]
  9. Effects of acute ovariectomy on the lordosis response of female rats. Moreines, J.K., Powers, J.B. Physiol. Behav. (1977) [Pubmed]
  10. Galanin microinjected into the medial preoptic nucleus facilitates female- and male-typical sexual behaviors in the female rat. Bloch, G.J., Butler, P.C., Kohlert, J.G. Physiol. Behav. (1996) [Pubmed]
  11. Midbrain microinfusions of prolactin increase the estrogen-dependent behavior, lordosis. Harlan, R.E., Shivers, B.D., Pfaff, D.W. Science (1983) [Pubmed]
  12. Hormonal and genetic influences on arousal--sexual and otherwise. Pfaff, D., Frohlich, J., Morgan, M. Trends Neurosci. (2002) [Pubmed]
  13. Progesterone receptors as neuroendocrine integrators. Levine, J.E., Chappell, P.E., Schneider, J.S., Sleiter, N.C., Szabo, M. Frontiers in neuroendocrinology. (2001) [Pubmed]
  14. The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions. Kow, L.M., Pfaff, D.W. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Nitric oxide mediates sexual behavior in female rats. Mani, S.K., Allen, J.M., Rettori, V., McCann, S.M., O'Malley, B.W., Clark, J.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  16. Mating-related stimulation induces phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in progestin receptor-containing areas in the female rat brain. Meredith, J.M., Moffatt, C.A., Auger, A.P., Snyder, G.L., Greengard, P., Blaustein, J.D. J. Neurosci. (1998) [Pubmed]
  17. Dopaminergic regulation of progesterone receptors: brain D5 dopamine receptors mediate induction of lordosis by D1-like agonists in rats. Apostolakis, E.M., Garai, J., Fox, C., Smith, C.L., Watson, S.J., Clark, J.H., O'Malley, B.W. J. Neurosci. (1996) [Pubmed]
  18. Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice. Ogawa, S., Chan, J., Chester, A.E., Gustafsson, J.A., Korach, K.S., Pfaff, D.W. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  19. Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: a review. Kow, L.M., Mobbs, C.V., Pfaff, D.W. Neuroscience and biobehavioral reviews. (1994) [Pubmed]
  20. Sex-dependent differences in estrogen regulation of choline acetyltransferase are altered by neonatal treatments. Luine, V.N., Renner, K.J., McEwen, B.S. Endocrinology (1986) [Pubmed]
  21. Effects of testosterone propionate or dihydrotestosterone propionate on plasma FSH and LH levels in neonatal rats and on sexual differentiation of the brain. Korenbrot, C.C., Paup, D.C., Gorski, R.A. Endocrinology (1975) [Pubmed]
  22. Steroid priming promotes oxytocin-induced norepinephrine release in the ventromedial hypothalamus of female rats. Vincent, P.A., Etgen, A.M. Brain Res. (1993) [Pubmed]
  23. In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats. Apostolakis, E.M., Garai, J., Clark, J.H., O'Malley, B.W. Mol. Endocrinol. (1996) [Pubmed]
  24. Antagonism of female sexual behavior with intracerebral implants of antiprogestin RU 38486: correlation with binding to neural progestin receptors. Etgen, A.M., Barfield, R.J. Endocrinology (1986) [Pubmed]
  25. 1-(o-chlorophenyl)-1-(p-chlorophenyl)2,2,2-trichloroethane: a probe for studying estrogen and progestin receptor mediation of female sexual behavior and neuroendocrine responses. Etgen, A.M. Endocrinology (1982) [Pubmed]
  26. Epidermal growth factor activates reproductive behavior independent of ovarian steroids in female rodents. Apostolakis, E.M., Garai, J., Lohmann, J.E., Clark, J.H., O'Malley, B.W. Mol. Endocrinol. (2000) [Pubmed]
  27. Neuropeptide Y inhibits estrous behavior and stimulates feeding via separate receptors in Syrian hamsters. Corp, E.S., Gréco, B., Powers, J.B., Marín Bivens, C.L., Wade, G.N. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  28. Oxytocin facilitates the sexual receptivity of estrogen-treated female rats. Caldwell, J.D., Prange, A.J., Pedersen, C.A. Neuropeptides (1986) [Pubmed]
  29. Infusion of CCK-A receptor mRNA antisense oligodeoxynucleotides inhibits lordosis behavior. Holland, K.L., Popper, P., Micevych, P.E. Physiol. Behav. (1997) [Pubmed]
  30. A comparative study of different amphetamines on copulatory behavior and stereotype activity in the female rat. Michanek, A., Meyerson, B.J. Psychopharmacology (Berl.) (1977) [Pubmed]
  31. The vomeronasal organ is required for the expression of lordosis behaviour, but not sex discrimination in female mice. Keller, M., Pierman, S., Douhard, Q., Baum, M.J., Bakker, J. Eur. J. Neurosci. (2006) [Pubmed]
  32. Estrogen regulation of noradrenergic signaling in the hypothalamus. Etgen, A.M., Karkanias, G.B. Psychoneuroendocrinology (1994) [Pubmed]
  33. Effects of androgens and estrogens on sexual differentiation of sex behavior, scent marking, and the sexually dimorphic area of the gerbil hypothalamus. Ulibarri, C., Yahr, P. Hormones and behavior. (1996) [Pubmed]
  34. Induction of lordosis in female rats: two modes of estrogen action and the effect of adrenalectomy. Kow, L.M., Pfaff, D.W. Hormones and behavior. (1975) [Pubmed]
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