Disease relevance of Fluosol 43

• Thus, while intense levels of hypoxia are required to stimulate the extrarenal production of Ep, these data suggest that as Fluosol-43 is taken up by the hepatic macrophages, Ep production by these cells is stimulated [1].
• Blood samples from rabbits given dispersed perfluorobutyltetrahydrofurane or perfluorotributylamine showed thrombocytopenia, prolongation of activated partial thromboplastin time, and decreases in Factors X and XI [2].
• This study reports an assessment of a method of intestinal protection by the intraluminal administration of an oxygenated perfluorochemical, perfluorotributylamine, or gaseous oxygen in an attempt to provide oxygen for mucosal cells rendered ischemia [3].
• In eyes with experimental retinal detachment perfluorotributylamine had physical properties which provided mechanical retinal tamponade [4].
• In two patients with severe proliferative vitreoretinopathy, perfluorotributylamine allowed adequate retinal tamponade and avoided a posterior retinotomy for internal drainage of subretinal fluid [5].

High impact information on Fluosol 43

• Isolated rat liver perfusions were performed with an oxygenated recycling perfusate consisting of a perfluorotributylamine/Pluronic F-68 emulsion (Fluosol 43) free of plasma proteins and blood cells [6].
• Neither mean cell volume nor white cells appear to be responsible for the observed effects of perfluorotributylamine [7].
• Oxygen kinetics in the vitreous substitute perfluorotributylamine: a 19F NMR study in vivo [8].
• Emulsions of perfluorotributylamine and perfluorodecalin, prepared by sonication, consisted largely of particles not exceeding 0.2 micrometer in diameter [9].
• Anticarcino-embryonic antigen (CEA) antibody conjugated with perfluorochemical (perfluorotributylamine, FTBA) was administered to nude mouse inoculated with LOVO, a CEA-producing human cancer cell line [10].

Chemical compound and disease context of Fluosol 43

• After splenectomy and extensive perfluorotributylamine exchange transfusion, steady-state spectral scans were obtained in Soret and visible wave-length regions during O2 ventilation, during subsequent exposure to O2-enriched gases containing 1, 3, or 5% CO, and finally after N2 anoxia [11].
• In four patients who had complicated retinal detachments I used perfluorotributylamine and perfluorodecalin during vitreous surgery [5].

Biological context of Fluosol 43

• A commonly available perflurocarbon, heptacosafluorotributylamine (Fluorinert), was used to deliver either plasmid DNA (pDNA) alone or cationic-lipid-complexed plasmid DNA to the lungs of Balb/c mice by direct intratracheal instillation [12].
• Rats were serially exchange transfused to hematocrits less than 2% (50-cc exchange) with either Krebs-Henseleit-albumin (KHA) solution or Fluosol-43 (F-43) [13].
• Circulating platelet counts were reduced from 875 +/- 47 X 10(3)/mm3 in sham controls (N = 21) to 75 +/- 10 X 10(3)/mm3 in Fluosol-43 exchange transfused rats (N2 = 19, P less than 0.001) [14].
• Oxygenated fluorocarbon (FC-43) donor lung preservation thus resulted in superior functional recovery in pulmonary gas exchange during reperfusion compared with Euro-Collins solution [15].
• In an experimental study in which a Fluosol-43 solution was compared to both crystalloid and oxygenated-blood cardioplegia, Fluosol-43-treated hearts demonstrated better recovery of left ventricular function following postischemic reperfusion [16].

Anatomical context of Fluosol 43

• Neutrophils isolated from blood of healthy donors were incubated at 37 degrees C for 1 hour with 25 percent Oxypherol (perfluorotributylamine) or Fluosol-DA (perfluorodecalin and perfluorotripropylamine) in the presence of fresh autologous serum [17].
• Since accumulation of perfluorochemicals in reticuloendothelial cells has been demonstrated, we tested the phagocytic function of monocytes and neutrophils in rabbit and human blood exposed in vivo and in vitro, respectively, to perfluorotributylamine (Oxypherol) a perfluorochemical blood substitute [18].
• The brain, rostral spinal cord and peripheral nervous system of the guinea pig were perfused in situ using an artificial blood containing the oxygen carrier, perfluorotributylamine (FC-43) [19].
• Oxygenated Fluosol-43 increased the deformability of HbSS erythrocytes and thereby reduced the resistance at flow rates less than 1 ml/min [20].
• Monkeys receiving emulsions of FC-47 (perfluorotributylamine) displayed vacuolated cells representing fluorocarbon throughout the reticuloendothelial system even six years later [21].

Associations of Fluosol 43 with other chemical compounds

• This study compares myocardial protection using nonoxygenated clear cardioplegia with oxygen-carrying solutions of blood (PO2, 100 mm Hg) and fluorocarbon (FC-47 perfluorotributylamine, PO2, 500 mm Hg), all containing 25 mEq/L of potassium chloride [22].
• Comparative investigation of disposition of 3,4-(methylenedioxy)methamphetamine (MDMA) in the rat and the mouse by a capillary gas chromatography-mass spectrometry assay based on perfluorotributylamine-enhanced ammonia positive ion chemical ionization [23].

Analytical, diagnostic and therapeutic context of Fluosol 43

• Rat livers, perfused for 5 h with a recycling fluid consisting of a perfluorochemical emulsion (Fluosol 43), were used to demonstrate a cumulative increase of HF in the perfusate as measured by a specific and sensitive radioimmunoassay [24].
• Oxygenated Fluosol-43 cardioplegia (CP), a perfluorocarbon with high oxygen solubility, was compared with crystalloid and oxygenated blood cardioplegia [25].
• We examined by light and electron microscopy (EM) histologic changes in liver, spleen, lung, and kidney of rabbits each infused with 20 to 40 mL of perfluorotributylamine or with lactated Ringer's solution (controls) [26].
• Intraperitoneal injection of 20 ml of the oxygen carrying fluorocarbon (perfluorotributylamine, FC-43) emulsion in three of the animals shifted the curve to the right improving venous oxygen content (p less than 0.1) [27].
• Fluosol-43 resuscitation resulted in a significantly higher (p less than 0.05) mean arterial pressure by 120 minutes post-resuscitation [28].

References