The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

RAB40B  -  RAB40B, member RAS oncogene family

Homo sapiens

Synonyms: Protein Rar, RAR, Ras-related protein Rab-40B, SEC4L, SOCS box-containing protein RAR
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RAB40B

  • The PLZF-RAR alpha fusion protein contains an approximately 120-amino-acid N-terminal motif (called the POZ domain), which is also found in a variety of zinc finger proteins and a group of poxvirus proteins and which mediates protein-protein interactions [1].
  • In the HepG2 human hepatoblastoma cell line, both at-RA and 9-cis RA as well as the retinoid X receptor (RXR)-specific agonist LGD 1069, but not the RA receptor (RAR) agonist ethyl-p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-l-pro penyl]-benzoic acid (TTNPB), induce apo A-II mRNA levels [2].
  • We conclude that CD437 can exert its effects in UMSCC22B human human head and neck squamous cell carcinoma cells by at least two mechanisms: RAR-mediated suppression of squamous differentiation and RAR-independent induction of apoptosis [3].
  • Our results suggest that in ovarian carcinomas, AHPN/CD437 induced apoptosis is mediated at least in part via an RAR pathway [4].
  • We aimed to study the effect of RA on RAR protein levels in MCF-7 human breast cancer cells [5].

High impact information on RAB40B

  • Treatment with RA would not only relieve this inhibition, but the activated PML-RAR protein may actually promote myelocyte differentiation [6].
  • The fusion PLZF-RAR alpha gene found in this case, was not found in DNA obtained from the bone marrow of normals, APL with t(15;17) and in one patient with AML-M2 with a t(11;17) [7].
  • These abnormal transactivation properties observed in retinoic acid-sensitive myeloid cells strongly implicate the PLZF-RAR alpha fusion proteins in the molecular pathogenesis of APL [8].
  • The hormone binding ability of the RAR alpha protein was assayed by a charcoal absorption assay and the RAR protein was found to bind to retinoic acid with a Kd of 2.1 x 10(-10) M [9].
  • In one case with a normal karyotype, FISH analysis revealed insertion of RAR alpha into 11q23, and PLZF-RAR alpha was the sole fusion gene formed [10].

Biological context of RAB40B


Anatomical context of RAB40B


Associations of RAB40B with chemical compounds

  • These data indicate that the NPM-RAR fusion proteins can modulate expression of retinoid-responsive genes in a positive or negative manner, depending on context of the promoter, and lend support to the hypothesis that aberrant transcriptional activation underlies the APL phenotype [11].
  • Another model demonstrates in vivo effects of pregnant rat mother's ethanol consumption on retinol, retinyl ester, RA content, RA receptor (RAR) binding, and the levels of RAR expression in developing fetal organs [19].

Other interactions of RAB40B


Analytical, diagnostic and therapeutic context of RAB40B


  1. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling. Ruthardt, M., Testa, U., Nervi, C., Ferrucci, P.F., Grignani, F., Puccetti, E., Grignani, F., Peschle, C., Pelicci, P.G. Mol. Cell. Biol. (1997) [Pubmed]
  2. Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor. Vu-Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Heyman, R.A., Staels, B., Auwerx, J. Mol. Cell. Biol. (1996) [Pubmed]
  3. Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells. Sun, S.Y., Yue, P., Chandraratna, R.A., Tesfaigzi, Y., Hong, W.K., Lotan, R. Mol. Pharmacol. (2000) [Pubmed]
  4. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. Holmes, W.F., Dawson, M.I., Soprano, R.D., Soprano, K.J. J. Cell. Physiol. (2000) [Pubmed]
  5. Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors alpha and gamma through proteasomes in MCF-7 human breast cancer cells. Tanaka, T., Rodríguez de la Concepción, M.L., De Luca, L.M. Biochem. Pharmacol. (2001) [Pubmed]
  6. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Kakizuka, A., Miller, W.H., Umesono, K., Warrell, R.P., Frankel, S.R., Murty, V.V., Dmitrovsky, E., Evans, R.M. Cell (1991) [Pubmed]
  7. Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. Chen, S.J., Zelent, A., Tong, J.H., Yu, H.Q., Wang, Z.Y., Derré, J., Berger, R., Waxman, S., Chen, Z. J. Clin. Invest. (1993) [Pubmed]
  8. PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors. Chen, Z., Guidez, F., Rousselot, P., Agadir, A., Chen, S.J., Wang, Z.Y., Degos, L., Zelent, A., Waxman, S., Chomienne, C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor. Yang, N., Schüle, R., Mangelsdorf, D.J., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies". Grimwade, D., Biondi, A., Mozziconacci, M.J., Hagemeijer, A., Berger, R., Neat, M., Howe, K., Dastugue, N., Jansen, J., Radford-Weiss, I., Lo Coco, F., Lessard, M., Hernandez, J.M., Delabesse, E., Head, D., Liso, V., Sainty, D., Flandrin, G., Solomon, E., Birg, F., Lafage-Pochitaloff, M. Blood (2000) [Pubmed]
  11. The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties. Redner, R.L., Chen, J.D., Rush, E.A., Li, H., Pollock, S.L. Blood (2000) [Pubmed]
  12. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Licht, J.D., Chomienne, C., Goy, A., Chen, A., Scott, A.A., Head, D.R., Michaux, J.L., Wu, Y., DeBlasio, A., Miller, W.H. Blood (1995) [Pubmed]
  13. Agonist and Antagonist of Retinoic Acid Receptors Cause Similar Changes in Gene Expression and Induce Senescence-like Growth Arrest in MCF-7 Breast Carcinoma Cells. Chen, Y., Dokmanovic, M., Stein, W.D., Ardecky, R.J., Roninson, I.B. Cancer Res. (2006) [Pubmed]
  14. Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells. Müller, S., Miller, W.H., Dejean, A. Blood (1998) [Pubmed]
  15. Retinoids and nonvertebrate chordate development. Fujiwara, S. J. Neurobiol. (2006) [Pubmed]
  16. Central pathways of pulmonary and lower airway vagal afferents. Kubin, L., Alheid, G.F., Zuperku, E.J., McCrimmon, D.R. J. Appl. Physiol. (2006) [Pubmed]
  17. Development and specific induction of apoptosis of cultured cell models overexpressing human tau during neural differentiation: Implication in Alzheimer's disease. Tsukane, M., Yoshizaki, C., Yamauchi, T. Anal. Biochem. (2007) [Pubmed]
  18. Chapter 19: What can we learn from seasonal animals about the regulation of energy balance? Morgan, P.J., Ross, A.W., Mercer, J.G., Barrett, P. Prog. Brain Res. (2006) [Pubmed]
  19. The interaction of ethanol and vitamin A as a potential mechanism for the pathogenesis of Fetal Alcohol syndrome. Zachman, R.D., Grummer, M.A. Alcohol. Clin. Exp. Res. (1998) [Pubmed]
  20. Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. Fisher, G.J., Talwar, H.S., Xiao, J.H., Datta, S.C., Reddy, A.P., Gaub, M.P., Rochette-Egly, C., Chambon, P., Voorhees, J.J. J. Biol. Chem. (1994) [Pubmed]
  21. Regulation of tyrosine hydroxylase gene expression by retinoic acid receptor. Jeong, H., Kim, M.S., Kim, S.W., Kim, K.S., Seol, W. J. Neurochem. (2006) [Pubmed]
  22. Molecular characterization of der(15)t(11;15) as a secondary cytogenetic abnormality in acute promyelocytic leukemia with cryptic PML-RAR alpha fusion on 17q. Wan, T.S., Ma, S.K., Yip, S.F., Yeung, Y.M., Chan, L.C. Cancer Genet. Cytogenet. (2000) [Pubmed]
WikiGenes - Universities