Gene Review:
CKS1B - CDC28 protein kinase regulatory subunit 1B
Homo sapiens
Synonyms:
CKS-1, CKS1, Cyclin-dependent kinases regulatory subunit 1, PNAS-143, PNAS-16, ...
- Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma. Masuda, T.A., Inoue, H., Nishida, K., Sonoda, H., Yoshikawa, Y., Kakeji, Y., Utsunomiya, T., Mori, M. Clin. Cancer Res. (2003)
- Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma. Shaughnessy, J. Hematology (2005)
- Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. Kitajima, S., Kudo, Y., Ogawa, I., Bashir, T., Kitagawa, M., Miyauchi, M., Pagano, M., Takata, T. Am. J. Pathol. (2004)
- ckshs expression is linked to cell proliferation in normal and malignant human lymphoid cells. Urbanowicz-Kachnowicz, I., Baghdassarian, N., Nakache, C., Gracia, D., Mekki, Y., Bryon, P.A., Ffrench, M. Int. J. Cancer (1999)
- High expression of Cks1 in human non-small cell lung carcinomas. Inui, N., Kitagawa, K., Miwa, S., Hattori, T., Chida, K., Nakamura, H., Kitagawa, M. Biochem. Biophys. Res. Commun. (2003)
- Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Hao, B., Zheng, N., Schulman, B.A., Wu, G., Miller, J.J., Pagano, M., Pavletich, N.P. Mol. Cell (2005)
- The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Ganoth, D., Bornstein, G., Ko, T.K., Larsen, B., Tyers, M., Pagano, M., Hershko, A. Nat. Cell Biol. (2001)
- Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation. Borriello, A., Cucciolla, V., Criscuolo, M., Indaco, S., Oliva, A., Giovane, A., Bencivenga, D., Iolascon, A., Zappia, V., Della Ragione, F. Cancer Res. (2006)
- The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. Shapira, M., Ben-Izhak, O., Linn, S., Futerman, B., Minkov, I., Hershko, D.D. Cancer (2005)
- Three different binding sites of Cks1 are required for p27-ubiquitin ligation. Sitry, D., Seeliger, M.A., Ko, T.K., Ganoth, D., Breward, S.E., Itzhaki, L.S., Pagano, M., Hershko, A. J. Biol. Chem. (2002)
- Using genomics to identify high-risk myeloma after autologous stem cell transplantation. Shaughnessy, J.D., Barlogie, B. Biol. Blood Marrow Transplant. (2006)
- Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation. Chang, H., Yeung, J., Xu, W., Ning, Y., Patterson, B. Br. J. Haematol. (2006)
- Multiple myeloma patients with CKS1B gene amplification have a shorter progression-free survival post-autologous stem cell transplantation. Chang, H., Qi, X., Trieu, Y., Xu, W., Reader, J.C., Ning, Y., Reece, D. Br. J. Haematol. (2006)
- Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins. Zancai, P., Dal Col, J., Piccinin, S., Guidoboni, M., Cariati, R., Rizzo, S., Boiocchi, M., Maestro, R., Dolcetti, R. Oncogene (2005)
- A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1. Wang, W., Ungermannova, D., Chen, L., Liu, X. J. Biol. Chem. (2003)
- Activation of Ubiquitin Ligase SCF(Skp2) by Cks1: Insights from Hydrogen Exchange Mass Spectrometry. Yao, Z.P., Zhou, M., Kelly, S.E., Seeliger, M.A., Robinson, C.V., Itzhaki, L.S. J. Mol. Biol. (2006)
- Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. Shapira, M., Ben-Izhak, O., Bishara, B., Futerman, B., Minkov, I., Krausz, M.M., Pagano, M., Hershko, D.D. Cancer (2004)
- The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. Slotky, M., Shapira, M., Ben-Izhak, O., Linn, S., Futerman, B., Tsalic, M., Hershko, D.D. Breast Cancer Res. (2005)
- RNA silencing of Cks1 induced G2/M arrest and apoptosis in human lung cancer cells. Tsai, Y.S., Chang, H.C., Chuang, L.Y., Hung, W.C. IUBMB Life (2005)
- Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma. Fonseca, R., Van Wier, S.A., Chng, W.J., Ketterling, R., Lacy, M.Q., Dispenzieri, A., Bergsagel, P.L., Rajkumar, S.V., Greipp, P.R., Litzow, M.R., Price-Troska, T., Henderson, K.J., Ahmann, G.J., Gertz, M.A. Leukemia (2006)