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Gene Review

Lch  -  low cholesterol

Mus musculus

Synonyms: Gena241, low HDL cholesterol
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Disease relevance of Lch


Psychiatry related information on Lch


High impact information on Lch


Biological context of Lch


Anatomical context of Lch

  • Herein, we studied the effects of C. pneumoniae infection and a diet with a low-cholesterol supplement on the development of autoantibodies to mouse Hsp60 and early lipid lesions in the aortic valve of C57BL/6JBom mice [16].
  • These results indicate that administration of hydroxytyrosol in low cholesterol diets increases atherosclerotic lesion associated with the degree of monocyte activation and remodelling of plasma lipoproteins [17].
  • In the aortic arch, HC+A but not LC blocked lesion progression [18].
  • HC+A and LC diet reduced, significantly and to the same extent, lesion progression and complication in the aortic root, as assessed by measuring total atherosclerotic lesion area, lesion severity, and macrophage and smooth muscle cell area [18].
  • It was also moderately decreased in the spleen of the low cholesterol-fed female mice and in the thyroid gland of the low cholesterol-fed male mice [19].

Associations of Lch with chemical compounds

  • This observation suggests the use of RXR-selective agonists, "rexinoids," either alone or in combination with a fibrate as a new therapeutic approach to treating patients with high triglyceride and low HDL cholesterol levels [20].
  • ACE activity (nmol. L His-Leu. mg protein(-1)) was measured in lung, kidney, and liver in control (receiving standard chow) and obese animals treated for 30 weeks with a high-fat, low cholesterol diet alone or in combination with LU135252, an orally active ET(A) receptor antagonist [21].
  • In mice fed a low cholesterol rodent diet containing SCH 58053, cholesterol absorption was reduced by 46% and fecal neutral sterol excretion was increased 67%, but biliary lipid composition and bile acid synthesis, pool size, and pool composition were unchanged [22].
  • We fed for 28 days male mice of 7 inbred strains either a low-cholesterol, commercial diet or a diet containing 2% (w/w) cholesterol, 0.5% cholic acid and 5% olive oil [23].
  • Compared with the LC control, avasimibe reduced lesion area by 78% [24].

Other interactions of Lch


Analytical, diagnostic and therapeutic context of Lch


  1. Endothelial lipase and HDL metabolism. Jaye, M., Krawiec, J. Curr. Opin. Lipidol. (2004) [Pubmed]
  2. Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance. Kalopissis, A.D., Pastier, D., Chambaz, J. Curr. Opin. Lipidol. (2003) [Pubmed]
  3. Endothelial nitric oxide synthase haplotypes are associated with features of metabolic syndrome. Gonz??lez-S??nchez, J.L., Mart??nez-Larrad, M.T., S??ez, M.E., Zabena, C., Mart??nez-Calatrava, M.J., Serrano-R??os, M. Clin. Chem. (2007) [Pubmed]
  4. Clinical significance of high-density lipoproteins and the development of atherosclerosis: focus on the role of the adenosine triphosphate-binding cassette protein A1 transporter. Brewer, H.B., Santamarina-Fojo, S. Am. J. Cardiol. (2003) [Pubmed]
  5. Limb, genital, CNS, and facial malformations result from gene/environment-induced cholesterol deficiency: further evidence for a link to sonic hedgehog. Lanoue, L., Dehart, D.B., Hinsdale, M.E., Maeda, N., Tint, G.S., Sulik, K.K. Am. J. Med. Genet. (1997) [Pubmed]
  6. Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reduction. Schaefer, E.J., Asztalos, B.F. Curr. Opin. Lipidol. (2006) [Pubmed]
  7. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Plump, A.S., Smith, J.D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J.G., Rubin, E.M., Breslow, J.L. Cell (1992) [Pubmed]
  8. Disruption of cholesterol homeostasis by plant sterols. Yang, C., Yu, L., Li, W., Xu, F., Cohen, J.C., Hobbs, H.H. J. Clin. Invest. (2004) [Pubmed]
  9. Absence of filipin-sterol complexes from large coated pits on the surface of culture cells. Montesano, R., Perrelet, A., Vassalli, P., Orci, L. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  10. alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Yi, X., Maeda, N. Diabetes (2006) [Pubmed]
  11. Saposin A Mobilizes Lipids from Low Cholesterol and High Bis(monoacylglycerol)phosphate-containing Membranes: PATIENT VARIANT SAPOSIN A LACKS LIPID EXTRACTION CAPACITY. Locatelli-Hoops, S., Remmel, N., Klingenstein, R., Breiden, B., Rossocha, M., Schoeniger, M., Koenigs, C., Saenger, W., Sandhoff, K. J. Biol. Chem. (2006) [Pubmed]
  12. Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. Lyons, M.A., Wittenburg, H., Li, R., Walsh, K.A., Churchill, G.A., Carey, M.C., Paigen, B. J. Lipid Res. (2003) [Pubmed]
  13. Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1. Uehara, Y., Engel, T., Li, Z., Goepfert, C., Rust, S., Zhou, X., Langer, C., Schachtrup, C., Wiekowski, J., Lorkowski, S., Assmann, G., von Eckardstein, A. Diabetes (2002) [Pubmed]
  14. Effects of high-fat, low-cholesterol diets on hepatic lipid peroxidation and antioxidants in apolipoprotein E-deficient mice. Ferré, N., Camps, J., Paul, A., Cabré, M., Calleja, L., Osada, J., Joven, J. Mol. Cell. Biochem. (2001) [Pubmed]
  15. RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion. Calleros, L., Lasa, M., Rodríguez-Alvarez, F.J., Toro, M.J., Chiloeches, A. Apoptosis (2006) [Pubmed]
  16. Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection. Erkkilä, L., Laitinen, K., Haasio, K., Tiirola, T., Jauhiainen, M., Lehr, H.A., Aalto-Setälä, K., Saikku, P., Leinonen, M. Atherosclerosis (2004) [Pubmed]
  17. Hydroxytyrosol administration enhances atherosclerotic lesion development in apo e deficient mice. Acín, S., Navarro, M.A., Arbonés-Mainar, J.M., Guillén, N., Sarría, A.J., Carnicer, R., Surra, J.C., Orman, I., Segovia, J.C., Torre, R.d.e. .L., Covas, M.I., Fernández-Bolaños, J., Ruiz-Gutiérrez, V., Osada, J. J. Biochem. (2006) [Pubmed]
  18. Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice. Verschuren, L., Kleemann, R., Offerman, E.H., Szalai, A.J., Emeis, S.J., Princen, H.M., Kooistra, T. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  19. Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice: inhibition of 2 independent cellular cholesterol-releasing pathways in vivo. Tomimoto, S., Tsujita, M., Okazaki, M., Usui, S., Tada, T., Fukutomi, T., Ito, S., Itoh, M., Yokoyama, S. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  20. RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo. Mukherjee, R., Strasser, J., Jow, L., Hoener, P., Paterniti, J.R., Heyman, R.A. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  21. Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin. Barton, M., Carmona, R., Morawietz, H., d'Uscio, L.V., Goettsch, W., Hillen, H., Haudenschild, C.C., Krieger, J.E., Münter, K., Lattmann, T., Lüscher, T.F., Shaw, S. Hypertension (2000) [Pubmed]
  22. Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte. Repa, J.J., Dietschy, J.M., Turley, S.D. J. Lipid Res. (2002) [Pubmed]
  23. Esterases in inbred strains of mice with differential cholesterolemic responses to a high-cholesterol diet. Beynen, A.C., Lemmens, A.G., De Bruijne, J.J., Ronai, A., Wassmer, B., Von Deimling, O., Katan, M.B., Van Zutphen, L.F. Atherosclerosis (1987) [Pubmed]
  24. Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Delsing, D.J., Offerman, E.H., van Duyvenvoorde, W., van Der Boom, H., de Wit, E.C., Gijbels, M.J., van Der Laarse, A., Jukema, J.W., Havekes, L.M., Princen, H.M. Circulation (2001) [Pubmed]
  25. Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue. Islam, K.K., Knight, B.L., Frayn, K.N., Patel, D.D., Gibbons, G.F. Biochim. Biophys. Acta (2005) [Pubmed]
  26. Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36. Parathath, S., Connelly, M.A., Rieger, R.A., Klein, S.M., Abumrad, N.A., De La Llera-Moya, M., Iden, C.R., Rothblat, G.H., Williams, D.L. J. Biol. Chem. (2004) [Pubmed]
  27. The apolipoprotein e knockout mouse: a model documenting accelerated atherogenesis in uremia. Buzello, M., Törnig, J., Faulhaber, J., Ehmke, H., Ritz, E., Amann, K. J. Am. Soc. Nephrol. (2003) [Pubmed]
  28. High density lipoproteins and coronary heart disease. Future prospects in gene therapy. Fruchart, J.C., Duriez, P. Biochimie (1998) [Pubmed]
  29. Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice. Zadelaar, A.S., Boesten, L.S., Jukema, J.W., van Vlijmen, B.J., Kooistra, T., Emeis, J.J., Lundholm, E., Camejo, G., Havekes, L.M. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
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