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Chemical Compound Review

dopet     4-(2-hydroxyethyl)benzene- 1,2-diol

Synonyms: Hydroxytyrosol, PubChem14271, SureCN44363, AG-B-92331, CHEMBL1950045, ...
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Disease relevance of Hydroxytyrosol


High impact information on Hydroxytyrosol


Chemical compound and disease context of Hydroxytyrosol


Biological context of Hydroxytyrosol


Anatomical context of Hydroxytyrosol


Associations of Hydroxytyrosol with other chemical compounds


Gene context of Hydroxytyrosol


Analytical, diagnostic and therapeutic context of Hydroxytyrosol


  1. Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. D'Angelo, S., Ingrosso, D., Migliardi, V., Sorrentino, A., Donnarumma, G., Baroni, A., Masella, L., Tufano, M.A., Zappia, M., Galletti, P. Free Radic. Biol. Med. (2005) [Pubmed]
  2. Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells. Galletti, P., Di Gennaro, C.I., Migliardi, V., Indaco, S., Della Ragione, F., Manna, C., Chiodini, P., Capasso, G., Zappia, V. Nephrol. Dial. Transplant. (2005) [Pubmed]
  3. Production of High Hydroxytyrosol Yields via Tyrosol Conversion by Pseudomonas aeruginosa Immobilized Resting Cells. Bouallagui, Z., Sayadi, S. J. Agric. Food Chem. (2006) [Pubmed]
  4. Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells. Mateos, R., Goya, L., Bravo, L. J. Agric. Food Chem. (2005) [Pubmed]
  5. Hypocholesterolemic effects of phenolic extracts and purified hydroxytyrosol recovered from olive mill wastewater in rats fed a cholesterol-rich diet. Fki, I., Sahnoun, Z., Sayadi, S. J. Agric. Food Chem. (2007) [Pubmed]
  6. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., Coval, S.M., Binkoski, A.E., Hilpert, K.F., Griel, A.E., Etherton, T.D. Am. J. Med. (2002) [Pubmed]
  7. Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. Guichard, C., Pedruzzi, E., Fay, M., Marie, J.C., Braut-Boucher, F., Daniel, F., Grodet, A., Gougerot-Pocidalo, M.A., Chastre, E., Kotelevets, L., Lizard, G., Vandewalle, A., Driss, F., Ogier-Denis, E. Carcinogenesis (2006) [Pubmed]
  8. Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. Bitler, C.M., Viale, T.M., Damaj, B., Crea, R. J. Nutr. (2005) [Pubmed]
  9. Antioxidants induce different phenotypes by a distinct modulation of signal transduction. Della Ragione, F., Cucciolla, V., Criniti, V., Indaco, S., Borriello, A., Zappia, V. FEBS Lett. (2002) [Pubmed]
  10. Olive oil phenols are absorbed in humans. Vissers, M.N., Zock, P.L., Roodenburg, A.J., Leenen, R., Katan, M.B. J. Nutr. (2002) [Pubmed]
  11. Synthesis of hydroxytyrosol, 2-hydroxyphenylacetic acid, and 3-hydroxyphenylacetic acid by differential conversion of tyrosol isomers using Serratia marcescens strain. Allouche, N., Sayadi, S. J. Agric. Food Chem. (2005) [Pubmed]
  12. The in vivo fate of hydroxytyrosol and tyrosol, antioxidant phenolic constituents of olive oil, after intravenous and oral dosing of labeled compounds to rats. Tuck, K.L., Freeman, M.P., Hayball, P.J., Stretch, G.L., Stupans, I. J. Nutr. (2001) [Pubmed]
  13. The fate of olive oil polyphenols in the gastrointestinal tract: Implications of gastric and colonic microflora-dependent biotransformation. Corona, G., Tzounis, X., Assunta Dessì, M., Deiana, M., Debnam, E.S., Visioli, F., Spencer, J.P. Free Radic. Res. (2006) [Pubmed]
  14. Anti-oxidant sensitivity of donor age-related gene expression in cultured fibroblasts. Braam, B., Langelaar-Makkinje, M., Verkleij, A., Bluyssen, H., Verrips, T., Koomans, H.A., Joles, J.A., Post, J.A. Eur. J. Pharmacol. (2006) [Pubmed]
  15. The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation. Corona, G., Tzounis, X., Assunta Dessì, M., Deiana, M., Debnam, E.S., Visioli, F., Spencer, J.P. Free Radic. Res. (2006) [Pubmed]
  16. Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cells. Manna, C., Galletti, P., Maisto, G., Cucciolla, V., D'Angelo, S., Zappia, V. FEBS Lett. (2000) [Pubmed]
  17. Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. O'Dowd, Y., Driss, F., Dang, P.M., Elbim, C., Gougerot-Pocidalo, M.A., Pasquier, C., El-Benna, J. Biochem. Pharmacol. (2004) [Pubmed]
  18. Conjoint radioenzymatic measurement of catecholamines, their catechol metabolites and DOPA in biological samples. Thiede, H.M., Kehr, W. Naunyn Schmiedebergs Arch. Pharmacol. (1981) [Pubmed]
  19. Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans. Visioli, F., Caruso, D., Galli, C., Viappiani, S., Galli, G., Sala, A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  20. Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells. Maccaglia, A., Mallozzi, C., Minetti, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  21. Isolation and identification of radical scavengers in olive tree (Olea europaea) wood. Pérez-Bonilla, M., Salido, S., van Beek, T.A., Linares-Palomino, P.J., Altarejos, J., Nogueras, M., Sánchez, A. Journal of chromatography. A. (2006) [Pubmed]
  22. Hydroxytyrosol, a phenolic compound from virgin olive oil, prevents macrophage activation. Maiuri, M.C., De Stefano, D., Di Meglio, P., Irace, C., Savarese, M., Sacchi, R., Cinelli, M.P., Carnuccio, R. Naunyn Schmiedebergs Arch. Pharmacol. (2005) [Pubmed]
  23. Hydroxytyrosol administration enhances atherosclerotic lesion development in apo e deficient mice. Acín, S., Navarro, M.A., Arbonés-Mainar, J.M., Guillén, N., Sarría, A.J., Carnicer, R., Surra, J.C., Orman, I., Segovia, J.C., Torre, R.d.e. .L., Covas, M.I., Fernández-Bolaños, J., Ruiz-Gutiérrez, V., Osada, J. J. Biochem. (2006) [Pubmed]
  24. Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis. Ragione, F.D., Cucciolla, V., Borriello, A., Pietra, V.D., Pontoni, G., Racioppi, L., Manna, C., Galletti, P., Zappia, V. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  25. Synthesis of the antioxidant hydroxytyrosol using tyrosinase as biocatalyst. Espín, J.C., Soler-Rivas, C., Cantos, E., Tomás-Barberán, F.A., Wichers, H.J. J. Agric. Food Chem. (2001) [Pubmed]
  26. Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis. Fabiani, R., De Bartolomeo, A., Rosignoli, P., Servili, M., Montedoro, G.F., Morozzi, G. Eur. J. Cancer Prev. (2002) [Pubmed]
  27. Determination of hydroxytyrosol in plasma by HPLC. Ruiz-Gutiérrez, V., Juan, M.E., Cert, A., Planas, J.M. Anal. Chem. (2000) [Pubmed]
  28. Hydrolysis of oleuropein by recombinant beta-glycosidase from hyperthermophilic archaeon Sulfolobus solfataricus immobilised on chitosan matrix. Briante, R., La Cara, F., Febbraio, F., Barone, R., Piccialli, G., Carolla, R., Mainolfi, P., De Napoli, L., Patumi, M., Fontanazza, G., Nucci, R. J. Biotechnol. (2000) [Pubmed]
  29. On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. Bisignano, G., Tomaino, A., Lo Cascio, R., Crisafi, G., Uccella, N., Saija, A. J. Pharm. Pharmacol. (1999) [Pubmed]
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