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Gene Review

Hal  -  histidine ammonia lyase

Mus musculus

Synonyms: Histidase, Histidine ammonia-lyase, Hsd, Huth, his, ...
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Disease relevance of Hal


High impact information on Hal


Chemical compound and disease context of Hal


Biological context of Hal

  • Identification of the mutation in murine histidinemia (his) and genetic mapping of the murine histidase locus (Hal) on chromosome 10 [6].
  • Male MF1-nu/nu/Ola/Hsd nude mice, maintained in a gnotobiotic environment, were dosed i.p. with either 50, 100 or 200 mg/kg 2-bromoethanamine (BEA) hydrobromide to induce a model papillary necrosis [7].

Anatomical context of Hal

  • The homologous locus in the mouse (Hal) was mapped to region 10C2----D1 by in situ hybridization, using a cell line from a mouse homozygous for a 1.10 Robertsonian translocation [8].
  • Expression of the R322Q allele in COS cells resulted in proportionately reduced amounts of histidase protein and activity compared to the wildtype allele [6].

Associations of Hal with chemical compounds

  • Based on results of the acute study, the immediate and lasting effects of chronic low-dose ketamine on AEPs were examined among C3H/HeHsd (sensitive) and FVB/Hsd (insensitive) mice [5].
  • L-histidine ammonia-lyase (histidase) was encapsulated within cellulose nitrate artificial cells, and its kinetic parameters were evaluated [9].

Other interactions of Hal


Analytical, diagnostic and therapeutic context of Hal


  1. Decrease of epidermal histidase activity by tumor-promoting phorbol esters. Colburn, N.H., Lau, S., Head, R. Cancer Res. (1975) [Pubmed]
  2. Inducibility of thymic lymphomas in female Hsd: (ICR)BR mice following subcutaneous injection of ethyl- and isopropyl methanesulfonate. Segal, A., Sellakumar, A. Cancer Lett. (1989) [Pubmed]
  3. Mousepox resulting from use of ectromelia virus-contaminated, imported mouse serum. Lipman, N.S., Perkins, S., Nguyen, H., Pfeffer, M., Meyer, H. Comp. Med. (2000) [Pubmed]
  4. Histidinemia in mice: a metabolic defect treated using a novel approach to hepatocellular transplantation. Selden, C., Calnan, D., Morgan, N., Wilcox, H., Carr, E., Hodgson, H.J. Hepatology (1995) [Pubmed]
  5. Ketamine produces lasting disruptions in encoding of sensory stimuli. Maxwell, C.R., Ehrlichman, R.S., Liang, Y., Trief, D., Kanes, S.J., Karp, J., Siegel, S.J. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  6. Identification of the mutation in murine histidinemia (his) and genetic mapping of the murine histidase locus (Hal) on chromosome 10. Taylor, R.G., Grieco, D., Clarke, G.A., McInnes, R.R., Taylor, B.A. Genomics (1993) [Pubmed]
  7. 2-Bromoethanamine nephrotoxicity in the nude mouse: an atypical targetting for the renal cortex. Gregg, N.J., Bach, P.H. International journal of experimental pathology. (1990) [Pubmed]
  8. Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1. Taylor, R.G., García-Heras, J., Sadler, S.J., Lafreniere, R.G., Willard, H.F., Ledbetter, D.H., McInnes, R.R. Cytogenet. Cell Genet. (1991) [Pubmed]
  9. Characterization of L-histidine ammonia-lyase immobilized by microencapsulation in artificial cells: preparation, kinetics, stability, and in vitro depletion of histidine. Khanna, R., Chang, T.M. The International journal of artificial organs. (1990) [Pubmed]
  10. Genetic variation in the activity of the histidine catabolic enzymes between inbred strains of mice: a structural locus for a cytosol histidine aminotransferase isozyme (Hat-1). Bulfield, G. Biochem. Genet. (1978) [Pubmed]
  11. Genetic differences inthe te of histidase synthesis in inbred mice. Hanford, W.C., Arfin, S.M. J. Biol. Chem. (1977) [Pubmed]
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