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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Therapies, Investigational

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Disease relevance of Therapies, Investigational


Psychiatry related information on Therapies, Investigational


High impact information on Therapies, Investigational

  • IMPLICATIONS: The fact that p185 immunoreactivity is rarely heterogeneous is encouraging, both for the potential use of HER-2/neu-related proteins as serum tumor markers and for innovative therapies targeted at p185 expression [8].
  • New experimental therapies aim to mimic tolerogenic antigen signals by chronically stimulating antigen receptors with antigen or antibodies to the receptor, or aim to block costimulatory pathways involving CD40 ligand, B7, or interleukin 2 [9].
  • Recent studies suggest that the neutralization of peroxynitrite or pharmacological inhibition of MMPs and PARP are promising new approaches in the experimental therapy of various forms of myocardial injury [10].
  • We therefore propose that cyclin D1-positivity should be included as one of the standard criteria for MCL, and that innovative therapies for this incurable disease should be explored on the basis of the new criteria [11].
  • Standard therapy was weekly cisplatin 40 mg/m2, and experimental therapy was PVI FU 225 mg/m2/d for 5 d/wk for six cycles during RT [12].

Chemical compound and disease context of Therapies, Investigational


Biological context of Therapies, Investigational


Anatomical context of Therapies, Investigational


Associations of Therapies, Investigational with chemical compounds


Gene context of Therapies, Investigational

  • GED or its derivatives may be useful tools in the experimental therapy of inflammatory conditions associated with NO overproduction due to iNOS expression [33].
  • A number of experimental therapies have been found to be effective in the treatment of RA, although the effects of these therapies on cytokine production have not been evaluated [34].
  • One such experimental therapy involves administration of a MoAb to intercellular adhesion molecule-1 (ICAM-1) that has been shown to be clinically beneficial in approximately 60% of the patients, with some patients responding for up to 11 months [34].
  • Thus, the JAB1:p27 ratio may be a novel indicator of aggressive, high-grade tumor behavior, and control of JAB1 could be a novel target for experimental therapies [35].
  • New experimental therapies for prostate cancer are aimed to down-regulate AR expression and to overcome difficulties which occur because of the acquisition of agonistic properties of commonly used antiandrogens [36].

Analytical, diagnostic and therapeutic context of Therapies, Investigational


  1. Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. McFarland, H.F., Frank, J.A., Albert, P.S., Smith, M.E., Martin, R., Harris, J.O., Patronas, N., Maloni, H., McFarlin, D.E. Ann. Neurol. (1992) [Pubmed]
  2. The effect of epidermal growth factor receptor (EGFR) expression on in vivo growth of rat C6 glioma cells. Fenstermaker, R.A., Capala, J., Barth, R.F., Hujer, A., Kung, H.J., Kaetzel, D.M. Leukemia (1995) [Pubmed]
  3. Adenovirus-mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo. Köck, H., Harris, M.P., Anderson, S.C., Machemer, T., Hancock, W., Sutjipto, S., Wills, K.N., Gregory, R.J., Shepard, H.M., Westphal, M., Maneval, D.C. Int. J. Cancer (1996) [Pubmed]
  4. Oral idarubicin as treatment for advanced myelodysplastic syndrome. Lowenthal, R.M., Lambertenghi-Deliliers, G. Haematologica (1991) [Pubmed]
  5. Induction of erythroid differentiation of human K562 cells by cisplatin analogs. Bianchi, N., Ongaro, F., Chiarabelli, C., Gualandi, L., Mischiati, C., Bergamini, P., Gambari, R. Biochem. Pharmacol. (2000) [Pubmed]
  6. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. DeKosky, S.T., Harbaugh, R.E., Schmitt, F.A., Bakay, R.A., Chui, H.C., Knopman, D.S., Reeder, T.M., Shetter, A.G., Senter, H.J., Markesbery, W.R. Ann. Neurol. (1992) [Pubmed]
  7. Immunomodulation by 9-amino-1,2,3,4-tetrahydroacridine (THA): 1. Down-regulation of natural cell-mediated cytotoxicity in vitro. Krishnaraj, R. Immunopharmacology (1991) [Pubmed]
  8. Stability of HER-2/neu expression over time and at multiple metastatic sites. Niehans, G.A., Singleton, T.P., Dykoski, D., Kiang, D.T. J. Natl. Cancer Inst. (1993) [Pubmed]
  9. Pathways for self-tolerance and the treatment of autoimmune diseases. Goodnow, C.C. Lancet (2001) [Pubmed]
  10. Nitrosative stress and pharmacological modulation of heart failure. Pacher, P., Schulz, R., Liaudet, L., Szabó, C. Trends Pharmacol. Sci. (2005) [Pubmed]
  11. Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma. Yatabe, Y., Suzuki, R., Tobinai, K., Matsuno, Y., Ichinohasama, R., Okamoto, M., Yamaguchi, M., Tamaru, J., Uike, N., Hashimoto, Y., Morishima, Y., Suchi, T., Seto, M., Nakamura, S. Blood (2000) [Pubmed]
  12. Randomized comparison of weekly cisplatin or protracted venous infusion of fluorouracil in combination with pelvic radiation in advanced cervix cancer: a gynecologic oncology group study. Lanciano, R., Calkins, A., Bundy, B.N., Parham, G., Lucci, J.A., Moore, D.H., Monk, B.J., O'Connor, D.M. J. Clin. Oncol. (2005) [Pubmed]
  13. Expanded clinical trials of treatments for multiple sclerosis: copolymer 1 (COP-1) treatment investigational new drug (IND) program. Stark, Y. Ann. Neurol. (1994) [Pubmed]
  14. Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity. Shie, F.S., Breyer, R.M., Montine, T.J. Am. J. Pathol. (2005) [Pubmed]
  15. Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review. Cannon, G.W., Jackson, C.G., Samuelson, C.O., Ward, J.R., Williams, H.J., Clegg, D.O. Semin. Arthritis Rheum. (1985) [Pubmed]
  16. Dexamethasone treatment of congenital adrenal hyperplasia in utero: an experimental therapy of unproven safety. Miller, W.L. J. Urol. (1999) [Pubmed]
  17. Sézary syndrome: diagnosis, prognosis, and critical review of treatment options. Wieselthier, J.S., Koh, H.K. J. Am. Acad. Dermatol. (1990) [Pubmed]
  18. Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. Binder, C.J., Weiher, H., Exner, M., Kerjaschki, D. Am. J. Pathol. (1999) [Pubmed]
  19. Vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs. Stadlbauer, K.H., Wagner-Berger, H.G., Raedler, C., Voelckel, W.G., Wenzel, V., Krismer, A.C., Klima, G., Rheinberger, K., Nussbaumer, W., Pressmar, D., Lindner, K.H., Königsrainer, A. Anesthesiology (2003) [Pubmed]
  20. Chemical induction of brain tumors in rats by nitrosoureas: molecular biology and neuropathology. Bilzer, T., Reifenberger, G., Wechsler, W. Neurotoxicology and teratology. (1989) [Pubmed]
  21. Experimental gene therapy in mammary and urinary bladder cancer using electrogene transfer. Shibata, M.A., Morimoto, J., Ito, Y., Kusakabe, K., Otsuki, Y. Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan. (2004) [Pubmed]
  22. Genetic abnormalities and drug resistance in acute lymphoblastic leukemia. Pui, C.H., Evans, W.E. Adv. Exp. Med. Biol. (1999) [Pubmed]
  23. Influence of pinealectomy on the amygdala kindling development in rats. Janjoppi, L., Silva de Lacerda, A.F., Scorza, F.A., Amado, D., Cavalheiro, E.A., Arida, R.M. Neurosci. Lett. (2006) [Pubmed]
  24. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis. Santos, A., Humayun, M.S., de Juan, E., Greenburg, R.J., Marsh, M.J., Klock, I.B., Milam, A.H. Arch. Ophthalmol. (1997) [Pubmed]
  25. Carcinoembryonic antigen as a target for radioimmunotherapy of human medullary thyroid carcinoma: antibody processing, targeting, and experimental therapy with 131I and 90Y labeled MAbs. Stein, R., Juweid, M., Mattes, M.J., Goldenberg, D.M. Cancer Biother. Radiopharm. (1999) [Pubmed]
  26. Hemopoietic stem cell transplantation in refractory rheumatoid arthritis is not a contraindication for reconstructive surgery. Espigado, I., García, A., Rodríguez, J.M., Valenzuela, A., Marín-Niebla, A., Carmona, M. Clinical and experimental rheumatology. (2003) [Pubmed]
  27. Cytokine modulation in sepsis and septic shock. Zanotti, S., Kumar, A., Kumar, A. Expert opinion on investigational drugs. (2002) [Pubmed]
  28. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study. Lokich, J.J., Ahlgren, J.D., Gullo, J.J., Philips, J.A., Fryer, J.G. J. Clin. Oncol. (1989) [Pubmed]
  29. Anti-inflammatory effects of clopidogrel intake in renal transplant patients: effects on platelet-leukocyte interactions, platelet CD40 ligand expression, and proinflammatory biomarkers. Graff, J., Harder, S., Wahl, O., Scheuermann, E.H., Gossmann, J. Clin. Pharmacol. Ther. (2005) [Pubmed]
  30. B7-1-transfected tumor vaccine counteracts chemotherapy-induced immunosuppression and prolongs the survival of rats bearing highly metastatic osteosarcoma cells. Hayakawa, M., Kawaguchi, S., Ishii, S., Murakami, M., Uede, T. Int. J. Cancer (1997) [Pubmed]
  31. Quantification of galactosylsphingosine in the twitcher mouse using electrospray ionization-tandem mass spectrometry. Whitfield, P.D., Sharp, P.C., Taylor, R., Meikle, P. J. Lipid Res. (2001) [Pubmed]
  32. Comparative efficacies of amphotericin B, triazoles, and combination of both as experimental therapy for murine trichosporonosis. Anaissie, E.J., Hachem, R., Karyotakis, N.C., Gokaslan, A., Dignani, M.C., Stephens, L.C., Tin-U, C.K. Antimicrob. Agents Chemother. (1994) [Pubmed]
  33. Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform. Szabó, C., Bryk, R., Zingarelli, B., Southan, G.J., Gahman, T.C., Bhat, V., Salzman, A.L., Wolff, D.J. Br. J. Pharmacol. (1996) [Pubmed]
  34. Persistent reduction in IL-6 mRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis after treatment with a monoclonal antibody to CD54 (ICAM-1). Schulze-Koops, H., Lipsky, P.E., Kavanaugh, A.F., Davis, L.S. Clin. Exp. Immunol. (1996) [Pubmed]
  35. Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1). Kouvaraki, M.A., Rassidakis, G.Z., Tian, L., Kumar, R., Kittas, C., Claret, F.X. Cancer Res. (2003) [Pubmed]
  36. Androgen receptors in prostate cancer. Culig, Z., Klocker, H., Bartsch, G., Hobisch, A. Endocr. Relat. Cancer (2002) [Pubmed]
  37. Cortisol stimulation by recombinant interferon-alpha 2. Roosth, J., Pollard, R.B., Brown, S.L., Meyer, W.J. J. Neuroimmunol. (1986) [Pubmed]
  38. Improved outcome at 28 days of age for very low birth weight infants treated with a single dose of a synthetic surfactant. Bose, C., Corbet, A., Bose, G., Garcia-Prats, J., Lombardy, L., Wold, D., Donlon, D., Long, W. J. Pediatr. (1990) [Pubmed]
  39. Pharmacotherapy for allergic rhinitis: a critical review of leukotriene receptor antagonists compared with other treatments. Nathan, R.A. Ann. Allergy Asthma Immunol. (2003) [Pubmed]
  40. Dangers of growth hormone therapy in critically ill patients. Ruokonen, E., Takala, J. Ann. Med. (2000) [Pubmed]
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