Gene Review:
Pcmt1 - protein-L-isoaspartate (D-aspartate) O...
Mus musculus
Synonyms:
C79501, L-isoaspartyl protein carboxyl methyltransferase, PIMT, Protein L-isoaspartyl/D-aspartyl methyltransferase, Protein-L-isoaspartate(D-aspartate) O-methyltransferase, ...
- Phenotypic analysis of seizure-prone mice lacking L-isoaspartate (D-aspartate) O-methyltransferase. Kim, E., Lowenson, J.D., Clarke, S., Young, S.G. J. Biol. Chem. (1999)
- Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice. Lowenson, J.D., Kim, E., Young, S.G., Clarke, S. J. Biol. Chem. (2001)
- Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy. Yamamoto, A., Takagi, H., Kitamura, D., Tatsuoka, H., Nakano, H., Kawano, H., Kuroyanagi, H., Yahagi, Y., Kobayashi, S., Koizumi, K., Sakai, T., Saito, K., Chiba, T., Kawamura, K., Suzuki, K., Watanabe, T., Mori, H., Shirasawa, T. J. Neurosci. (1998)
- Trypanosoma brucei prenylated-protein carboxyl methyltransferase prefers farnesylated substrates. Buckner, F.S., Kateete, D.P., Lubega, G.W., Van Voorhis, W.C., Yokoyama, K. Biochem. J. (2002)
- Methylation of 21-23 kD membrane proteins by a membrane-associated protein carboxyl methyltransferase in neuroblastoma cells. Increased methylation in differentiated cells. Haklai, R., Kloog, Y. Biochem. Pharmacol. (1990)
- Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain. Zhu, J.X., Doyle, H.A., Mamula, M.J., Aswad, D.W. J. Biol. Chem. (2006)
- Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B. Young, G.W., Hoofring, S.A., Mamula, M.J., Doyle, H.A., Bunick, G.J., Hu, Y., Aswad, D.W. J. Biol. Chem. (2005)
- Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase. Vitali, R., Clarke, S. Behav. Brain Res. (2004)
- Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice. Farrar, C.E., Huang, C.S., Clarke, S.G., Houser, C.R. J. Comp. Neurol. (2005)
- A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production. Doyle, H.A., Gee, R.J., Mamula, M.J. J. Immunol. (2003)
- Genomic organization and tissue expression of the murine gene encoding the protein beta-aspartate methyltransferase. Romanik, E.A., Ladino, C.A., Killoy, L.C., D'Ardenne, S.C., O'Connor, C.M. Gene (1992)
- Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. Farrar, C., Clarke, S. J. Biol. Chem. (2002)
- Isoaspartate formation and neurodegeneration in Alzheimer's disease. Shimizu, T., Watanabe, A., Ogawara, M., Mori, H., Shirasawa, T. Arch. Biochem. Biophys. (2000)
- Aspartimide formation in the joining peptide sequence of porcine and mouse pro-opiomelanocortin. Toney, K., Bateman, A., Gagnon, C., Bennett, H.P. J. Biol. Chem. (1993)
- Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice. Farrar, C., Houser, C.R., Clarke, S. Aging Cell (2005)
- A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida. Zhu, H., Yang, W., Lu, W., Zhang, J., Shaw, G.M., Lammer, E.J., Finnell, R.H. Mol. Genet. Metab. (2006)
- Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme. Young, A.L., Carter, W.G., Doyle, H.A., Mamula, M.J., Aswad, D.W. J. Biol. Chem. (2001)
- Transgenic expression of the protein-L-isoaspartyl methyltransferase (PIMT) gene in the brain rescues mice from the fatal epilepsy of PIMT deficiency. Shimizu, T., Ikegami, T., Ogawara, M., Suzuki, Y., Takahashi, M., Morio, H., Shirasawa, T. J. Neurosci. Res. (2002)
- Adenoviral expression of protein-L-isoaspartyl methyltransferase (PIMT) partially attenuates the biochemical changes in PIMT-deficient mice. Ogawara, M., Takahashi, M., Shimizu, T., Nakajima, M., Setoguchi, Y., Shirasawa, T. J. Neurosci. Res. (2002)
- Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis. Huebscher, K.J., Lee, J., Rovelli, G., Ludin, B., Matus, A., Stauffer, D., Fürst, P. Gene (1999)