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Gene Review

PEMT  -  phosphatidylethanolamine N-methyltransferase

Homo sapiens

Synonyms: PEAMT, PEMPT, PEMT2, PNMT, Phosphatidylethanolamine N-methyltransferase
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Disease relevance of PEMT

  • To evaluate the functional significance of PEMT localization, hepatoma cell lines were generated that stably expressed either ER- or Golgi-localized PEMT only [1].
  • For both cell types, the Km and specific activity of PEMT were comparable in normal and cystic fibrosis samples [2].
  • Several lines of evidence suggested that PEMT2 might have a role in hepatocyte proliferation and liver cancer [3].
  • Similarly, phosphatidylethanolamine methyltransferase (PEMT) activity, which is important for hepatic phosphatidylcholine (PC) synthesis, is also depressed in alcoholic liver disease, therefore calling for the administration of the products of the reaction [4].
  • PEMT as described is safe for domiciliary use and this study suggests that PEMT has a beneficial effect in the management of the acute whiplash injury [5].

Psychiatry related information on PEMT


High impact information on PEMT


Chemical compound and disease context of PEMT

  • Therefore, the hypothesis that reduced PEMT activity accounts for the impaired coupling of beta-adrenergic receptor to adenylate cyclase in lymphocytes and granulocytes in cystic fibrosis is rejected [2].
  • It is plausible that the decreased activity of phosphatidylethanolamine-N-methyltransferase and its low compensating ability could relate to the modification of phosphatidylcholine in brain tissues from Alzheimer's disease patients [6].
  • In the ventrolateral medulla, from the level of the obex to 11 mm rostral to the obex where the C1 group of neurons is located, there were 7,631 +/- 844 PNMT-positive neurons in control brains and 3,604 +/- 1,051 in brains affected by Parkinson's disease (47% of control) [11].
  • Our results demonstrate a selective loss of C1 and C3 PNMT-positive neurons, providing the first quantitative evidence for damage to these presumed brainstem sympathetic premotor neurons in Parkinson's disease [11].
  • The above differences in clinical presentation were largely explained by lower total tissue contents of catecholamines and expression of TH and negligible stores of epinephrine and expression of PNMT in pheochromocytomas from VHL than from MEN 2 patients [12].

Biological context of PEMT


Anatomical context of PEMT


Associations of PEMT with chemical compounds


Other interactions of PEMT


Analytical, diagnostic and therapeutic context of PEMT


  1. Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase. Shields, D.J., Lingrell, S., Agellon, L.B., Brosnan, J.T., Vance, D.E. J. Biol. Chem. (2005) [Pubmed]
  2. Lymphocyte and granulocyte phosphatidylethanolamine N-methyltransferase: properties and activity in cystic fibrosis. Davis, P.B. Pediatr. Res. (1986) [Pubmed]
  3. Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2. Walkey, C.J., Shields, D.J., Vance, D.E. Biochim. Biophys. Acta (1999) [Pubmed]
  4. Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy. Lieber, C.S. Critical reviews in clinical laboratory sciences. (2000) [Pubmed]
  5. Low energy high frequency pulsed electromagnetic therapy for acute whiplash injuries. A double blind randomized controlled study. Foley-Nolan, D., Moore, K., Codd, M., Barry, C., O'Connor, P., Coughlan, R.J. Scandinavian journal of rehabilitation medicine. (1992) [Pubmed]
  6. Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease. Guan, Z.Z., Wang, Y.N., Xiao, K.Q., Hu, P.S., Liu, J.L. Neurochem. Int. (1999) [Pubmed]
  7. Phenylethanolamine N-methyltransferase activity is decreased in Alzheimer's disease brains. Burke, W.J., Chung, H.D., Nakra, B.R., Grossberg, G.T., Joh, T.H. Ann. Neurol. (1987) [Pubmed]
  8. Presumptive adrenergic neurons containing phenylethanolamine N-methyltransferase immunoreactivity in the medulla oblongata of neonatal swine. Ruggiero, D.A., Anwar, M., Gootman, P.M. Brain Res. (1992) [Pubmed]
  9. Choline biosynthesis by a preparation enriched in synaptosomes from rat brain. Blusztajn, J.K., Wurtman, R.J. Nature (1981) [Pubmed]
  10. Nonadrenal epinephrine-forming enzymes in humans. Characteristics, distribution, regulation, and relationship to epinephrine levels. Kennedy, B., Bigby, T.D., Ziegler, M.G. J. Clin. Invest. (1995) [Pubmed]
  11. Loss of C1 and C3 epinephrine-synthesizing neurons in the medulla oblongata in Parkinson's disease. Gai, W.P., Geffen, L.B., Denoroy, L., Blessing, W.W. Ann. Neurol. (1993) [Pubmed]
  12. Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes. Eisenhofer, G., Walther, M.M., Huynh, T.T., Li, S.T., Bornstein, S.R., Vortmeyer, A., Mannelli, M., Goldstein, D.S., Linehan, W.M., Lenders, J.W., Pacak, K. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  13. Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase. Walkey, C.J., Donohue, L.R., Bronson, R., Agellon, L.B., Vance, D.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  14. Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase. Shields, D.J., Altarejos, J.Y., Wang, X., Agellon, L.B., Vance, D.E. J. Biol. Chem. (2003) [Pubmed]
  15. Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas. Tessitore, L., Marengo, B., Vance, D.E., Papotti, M., Mussa, A., Daidone, M.G., Costa, A. Oncology (2003) [Pubmed]
  16. Structure, expression profile and alternative processing of the human phosphatidylethanolamine N-methyltransferase (PEMT) gene. Shields, D.J., Agellon, L.B., Vance, D.E. Biochim. Biophys. Acta (2001) [Pubmed]
  17. Phosphatidylethanolamine N-methyltransferase in human red blood cell membrane preparations. Kinetic mechanism. Reitz, R.C., Mead, D.J., Bjur, R.A., Greenhouse, A.H., Welch, W.H. J. Biol. Chem. (1989) [Pubmed]
  18. Membrane topography of human phosphatidylethanolamine N-methyltransferase. Shields, D.J., Lehner, R., Agellon, L.B., Vance, D.E. J. Biol. Chem. (2003) [Pubmed]
  19. Common genetic polymorphisms affect the human requirement for the nutrient choline. da Costa, K.A., Kozyreva, O.G., Song, J., Galanko, J.A., Fischer, L.M., Zeisel, S.H. FASEB J. (2006) [Pubmed]
  20. Methionine-induced elevation of plasma homocysteine concentration is associated with an increase of plasma cholesterol in adult rats. Hirche, F., Schroder, A., Knoth, B., Stangl, G.I., Eder, K. Ann. Nutr. Metab. (2006) [Pubmed]
  21. Encephalitozoon cuniculi (Microspora): characterization of a phospholipid metabolic pathway potentially linked to therapeutics. El Alaoui, H., Bata, J., Peyret, P., Vivarès, C.P. Exp. Parasitol. (2001) [Pubmed]
  22. Positron emission mammography with tomographic acquisition using dual planar detectors: initial evaluations. Smith, M.F., Raylman, R.R., Majewski, S., Weisenberger, A.G. Physics in medicine and biology. (2004) [Pubmed]
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