The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Slc1a5  -  solute carrier family 1 (neutral amino...

Mus musculus

Synonyms: AAAT, ASC-like Na(+)-dependent neutral amino acid transporter ASCT2, ASCT2, ATB(0), ATBO, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Slc1a5

 

Biological context of Slc1a5

 

Anatomical context of Slc1a5

  • The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier [6].
  • Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes [3].
  • Unlike other sodium-dependent amino acid transporter mRNAs, the AAAT message is not expressed in brain, kidney, liver or heart and only traces are detected in spleen, thymus and skeletal muscle [3].
  • CRIA+ and CRIA+/- clonotypes were as heterogeneous as CRIA- antibodies, but a majority of CRIA+/- clones maintained a characteristic relative affinity for two of the haptens, p-arsanilic acid (p-ARS) and p-azobenene arsonic acid-N-tyrosine (ABA-tyr), which was identical to the prototype CRIA+ hybridoma protein R16 [7].
  • Despite the fact that all the chimeras form fully functional Ca2+ release channels in situ, sarcoplasmic reticulum (SR) containing R4, R10, and R16 did not possess high-affinity binding of [3H]ryanodine regardless of Ca2+ concentration [8].
 

Associations of Slc1a5 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Slc1a5

References

  1. Primary structure of IgE monoclonal antibodies expressing an intrastrain crossreactive idiotype. Haba, S., Rosen, E.M., Meek, K., Nisonoff, A. J. Exp. Med. (1986) [Pubmed]
  2. Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter. Utsunomiya-Tate, N., Endou, H., Kanai, Y. J. Biol. Chem. (1996) [Pubmed]
  3. Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes. Liao, K., Lane, M.D. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. An SP1-like cis-element is the major DNA motif for differential expression regulation of the adipocyte amino acid transporter. Zhu, Q., Zhu, J., Liao, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  5. Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-gamma and C/AAAT enhancer binding protein-alpha. Stewart, W.C., Morrison, R.F., Young, S.L., Stephens, J.M. Biochim. Biophys. Acta (1999) [Pubmed]
  6. The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier. Tetsuka, K., Takanaga, H., Ohtsuki, S., Hosoya, K., Terasaki, T. J. Neurochem. (2003) [Pubmed]
  7. Regulation of azophenylarsonate-specific repertoire expression. II. Fine specificity and isotype heterogeneity of anti-arsonate antibodies. Sigal, N.H. J. Immunol. (1983) [Pubmed]
  8. Conformational coupling of DHPR and RyR1 in skeletal myotubes is influenced by long-range allosterism: evidence for a negative regulatory module. Lee, E.H., Lopez, J.R., Li, J., Protasi, F., Pessah, I.N., Kim, d.o. .H., Allen, P.D. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  9. Functional and molecular analysis of d-serine transport in retinal M??ller cells. Dun, Y., Mysona, B., Itagaki, S., Martin-Studdard, A., Ganapathy, V., Smith, S.B. Exp. Eye Res. (2007) [Pubmed]
  10. Two types of deletion within integrated viral sequences mediate reversion of simian virus 40-transformed mouse cells. Maruyama, K., Oda, K. J. Virol. (1984) [Pubmed]
  11. Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells. Zhao, R., Gao, F., Goldman, I.D. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
 
WikiGenes - Universities