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Gene Review

SERPINA3  -  serpin peptidase inhibitor, clade A (alpha...

Homo sapiens

Synonyms: AACT, ACT, Alpha-1-antichymotrypsin, Cell growth-inhibiting gene 24/25 protein, GIG24, ...
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Disease relevance of SERPINA3


Psychiatry related information on SERPINA3


High impact information on SERPINA3


Chemical compound and disease context of SERPINA3


Biological context of SERPINA3


Anatomical context of SERPINA3


Associations of SERPINA3 with chemical compounds

  • BACKGROUND AND PURPOSE: The member 3 of clade A of serine proteinase inhibitors (SERPINA3), known previously as the alpha1-antichymotrypsin, is an acute phase protein, the levels of which increase in acute and chronic inflammation [2].
  • We also found that a variety of inflammatory mediators, cytokines, and steroid hormones are able to stimulate synthesis of alpha 1-AT and alpha 1-ACHY by MCF-7 cells [21].
  • Defensin interactions with either alpha 1-PI or alpha 1-ACT were not affected by iodoacetamide or high salt concentration [18].
  • METHODS AND RESULTS: Serial paraffin sections of nine consecutive cases of PTC were tested with anti-A1AT and anti-A1ACT antibodies [22].
  • We hypothesize that specific interactions of A beta with the inflammatory serpin, alpha 1-antichymotrypsin, abolish the serpin proteinase inhibitor activity and stimulate formation of the neurotoxic fibrillar form of A beta [23].

Physical interactions of SERPINA3


Regulatory relationships of SERPINA3


Other interactions of SERPINA3


Analytical, diagnostic and therapeutic context of SERPINA3


  1. SERPINA3 polymorphism is not associated with primary intracerebral hemorrhage in a Polish population. Pera, J., Slowik, A., Dziedzic, T., Szczudlik, A. Stroke (2006) [Pubmed]
  2. Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage. Slowik, A., Borratynska, A., Turaj, W., Pera, J., Dziedzic, T., Figlewicz, D.A., Betlej, M., Krzyszkowski, T., Czepko, R., Szczudlik, A. Stroke (2005) [Pubmed]
  3. Role of alpha-1-antichymotrypsin deficiency in promoting cirrhosis in two siblings with heterozygous alpha-1-antitrypsin deficiency phenotype SZ. Yoon, D., Kueppers, F., Genta, R.M., Klintmalm, G.B., Khaoustov, V.I., Yoffe, B. Gut (2002) [Pubmed]
  4. Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease. Kamboh, M.I., Minster, R.L., Kenney, M., Ozturk, A., Desai, P.P., Kammerer, C.M., DeKosky, S.T. Neurobiol. Aging (2006) [Pubmed]
  5. Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies. Distinctions between diseases. Lamb, H., Christie, J., Singleton, A.B., Leake, A., Perry, R.H., Ince, P.G., McKeith, I.G., Melton, L.M., Edwardson, J.A., Morris, C.M. Neurology (1998) [Pubmed]
  6. Immunohistochemical localization of lysozyme, lactoferrin, alpha 1-antichymotrypsin, and alpha 1-antitrypsin in salivary gland of human fetuses. Lee, S.K., Lim, C.Y., Chi, J.G., Yamada, K., Kunikata, M., Hashimura, K., Mori, M. Acta Histochem. (1990) [Pubmed]
  7. Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia. Rodriguez Martin, T., Calella, A.M., Silva, S., Munna, E., Modena, P., Chiesa, R., Terrevazzi, S., Ruggieri, R.M., Palermo, R., Piccoli, F., Confalonieri, R., Tiraboschi, P., Fragiacomo, C., Quadri, P., Lucca, U., Forloni, G. Dementia and geriatric cognitive disorders. (2000) [Pubmed]
  8. APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. Kamboh, M.I., Sanghera, D.K., Ferrell, R.E., DeKosky, S.T. Nat. Genet. (1995) [Pubmed]
  9. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Abraham, C.R., Selkoe, D.J., Potter, H. Cell (1988) [Pubmed]
  10. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Ma, J., Yee, A., Brewer, H.B., Das, S., Potter, H. Nature (1994) [Pubmed]
  11. Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. Winkler, I.G., Hendy, J., Coughlin, P., Horvath, A., Lévesque, J.P. J. Exp. Med. (2005) [Pubmed]
  12. The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population. Krischek, B., Akagawa, H., Tajima, A., Narita, A., Kasuya, H., Hori, T., Inoue, I. Cerebrovasc. Dis. (2007) [Pubmed]
  13. A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. Poller, W., Faber, J.P., Weidinger, S., Tief, K., Scholz, S., Fischer, M., Olek, K., Kirchgesser, M., Heidtmann, H.H. Genomics (1993) [Pubmed]
  14. Glucose removal from N-linked oligosaccharides is required for efficient maturation of certain secretory glycoproteins from the rough endoplasmic reticulum to the Golgi complex. Lodish, H.F., Kong, N. J. Cell Biol. (1984) [Pubmed]
  15. Clipsin, a chymotrypsin-like protease in rat brain which is irreversibly inhibited by alpha-1-antichymotrypsin. Nelson, R.B., Siman, R. J. Biol. Chem. (1990) [Pubmed]
  16. Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1. Billingsley, G.D., Walter, M.A., Hammond, G.L., Cox, D.W. Am. J. Hum. Genet. (1993) [Pubmed]
  17. The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. Horvath, A.J., Irving, J.A., Rossjohn, J., Law, R.H., Bottomley, S.P., Quinsey, N.S., Pike, R.N., Coughlin, P.B., Whisstock, J.C. J. Biol. Chem. (2005) [Pubmed]
  18. Human neutrophil defensin and serpins form complexes and inactivate each other. Panyutich, A.V., Hiemstra, P.S., van Wetering, S., Ganz, T. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  19. The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease. Faber, J.P., Poller, W., Olek, K., Baumann, U., Carlson, J., Lindmark, B., Eriksson, S. J. Hepatol. (1993) [Pubmed]
  20. Synthesis of alpha 1-antichymotrypsin and alpha 1-antitrypsin by human trophoblast. Bergman, D., Kadner, S.S., Cruz, M.R., Esterman, A.L., Tahery, M.M., Young, B.K., Finlay, T.H. Pediatr. Res. (1993) [Pubmed]
  21. alpha 1-Antitrypsin- and anchorage-independent growth of MCF-7 breast cancer cells. Finlay, T.H., Tamir, S., Kadner, S.S., Cruz, M.R., Yavelow, J., Levitz, M. Endocrinology (1993) [Pubmed]
  22. Alpha-1-antichymotrypsin immunoreactivity in papillary carcinoma of the thyroid gland. Lai, M.L., Rizzo, N., Liguori, C., Zucca, G., Faa, G. Histopathology (1998) [Pubmed]
  23. Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease. Janciauskiene, S., Wright, H.T. Bioessays (1998) [Pubmed]
  24. Characterization and determination of the complex between prostate-specific antigen and alpha 1-protease inhibitor in benign and malignant prostatic diseases. Zhang, W.M., Finne, P., Leinonen, J., Stenman, U.H. Scand. J. Clin. Lab. Invest. Suppl. (2000) [Pubmed]
  25. Production of alpha 1-antichymotrypsin by the J111 cell line. Berman, G., Burnett, D., Woo, S.L., Stockley, R.A. Biol. Chem. Hoppe-Seyler (1988) [Pubmed]
  26. Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype. Licastro, F., Mallory, M., Hansen, L.A., Masliah, E. J. Neuroimmunol. (1998) [Pubmed]
  27. Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3. Fielder, P.J., Rosenfeld, R.G., Graves, H.C., Grandbois, K., Maack, C.A., Sawamura, S., Ogawa, Y., Sommer, A., Cohen, P. Growth Regul. (1994) [Pubmed]
  28. Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. Nilsson, L.N., Bales, K.R., DiCarlo, G., Gordon, M.N., Morgan, D., Paul, S.M., Potter, H. J. Neurosci. (2001) [Pubmed]
  29. Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases. Camussi, G., Tetta, C., Bussolino, F., Baglioni, C. J. Exp. Med. (1988) [Pubmed]
  30. Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes. Perlmutter, D.H., Glover, G.I., Rivetna, M., Schasteen, C.S., Fallon, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  31. Biological activity of prostate-specific antigen isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electroelution. Tessmer, U., Quack, T., Donn, F., Leuner, A., Dernick, R. Electrophoresis (1995) [Pubmed]
  32. Conversion of alpha 1-antichymotrypsin into a human neutrophil elastase inhibitor: demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities. Rubin, H., Plotnick, M., Wang, Z.M., Liu, X., Zhong, Q., Schechter, N.M., Cooperman, B.S. Biochemistry (1994) [Pubmed]
  33. Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis. Tervahartiala, T., Konttinen, Y.T., INgman, T., Häyrinen-Immonen, R., Ding, Y., Sorsa, T. Journal of clinical periodontology. (1996) [Pubmed]
  34. Demonstration of alpha-1-antitrypsin and alpha-1-antichymotrypsin in fibrous histiocytomas using the immunoperoxidase technique. du Boulay, C.E. Am. J. Surg. Pathol. (1982) [Pubmed]
  35. Regional location of alpha 1-antichymotrypsin and alpha 1-antitrypsin genes on human chromosome 14. Rabin, M., Watson, M., Kidd, V., Woo, S.L., Breg, W.R., Ruddle, F.H. Somat. Cell Mol. Genet. (1986) [Pubmed]
  36. alpha 1-Antichymotrypsin in lung secretions is not an effective proteinase inhibitor. Berman, G., Afford, S.C., Burnett, D., Stockley, R.A. J. Biol. Chem. (1986) [Pubmed]
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