Gene Review:
Elane - elastase, neutrophil expressed
Mus musculus
Synonyms:
Ela2, Elastase-2, F430011M15Rik, Leukocyte elastase, NE, ...
Liu,
Zhou,
Shapiro,
Shipley,
Twining,
Diaz,
Senior,
Werb,
Churg,
Wright,
Terui,
Sano,
Okada,
Shirota,
Honda,
Ozawa,
Hirasawa,
Tamura,
Tagami,
Shapiro,
Goldstein,
Houghton,
Kobayashi,
Kelley,
Belaaouaj,
Lucattelli,
Bartalesi,
Cavarra,
Fineschi,
Lunghi,
Martorana,
Lungarella,
Edelstein,
Shapiro,
Klezovitch,
Scanu,
- The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Liu, Z., Zhou, X., Shapiro, S.D., Shipley, J.M., Twining, S.S., Diaz, L.A., Senior, R.M., Werb, Z. Cell (2000)
- Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Belaaouaj, A., McCarthy, R., Baumann, M., Gao, Z., Ley, T.J., Abraham, S.N., Shapiro, S.D. Nat. Med. (1998)
- Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis. Grenda, D.S., Johnson, S.E., Mayer, J.R., McLemore, M.L., Benson, K.F., Horwitz, M., Link, D.C. Blood (2002)
- Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Hirahashi, J., Mekala, D., Van Ziffle, J., Xiao, L., Saffaripour, S., Wagner, D.D., Shapiro, S.D., Lowell, C., Mayadas, T.N. Immunity (2006)
- Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Taooka, Y., Maeda, A., Hiyama, K., Ishioka, S., Yamakido, M. Am. J. Respir. Crit. Care Med. (1997)
- Deficiency in neutrophil elastase does not impair neutrophil recruitment to inflamed sites. Hirche, T.O., Atkinson, J.J., Bahr, S., Belaaouaj, A. Am. J. Respir. Cell Mol. Biol. (2004)
- Proteases and emphysema. Churg, A., Wright, J.L. Current opinion in pulmonary medicine. (2005)
- Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis. Morohoshi, Y., Matsuoka, K., Chinen, H., Kamada, N., Sato, T., Hisamatsu, T., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y., Hibi, T. J. Gastroenterol. (2006)
- Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. Young, R.E., Thompson, R.D., Larbi, K.Y., La, M., Roberts, C.E., Shapiro, S.D., Perretti, M., Nourshargh, S. J. Immunol. (2004)
- An enhancer located between the neutrophil elastase and proteinase 3 promoters is activated by Sp1 and an Ets factor. Nuchprayoon, I., Shang, J., Simkevich, C.P., Luo, M., Rosmarin, A.G., Friedman, A.D. J. Biol. Chem. (1999)
- Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology. Edelstein, C., Shapiro, S.D., Klezovitch, O., Scanu, A.M. J. Biol. Chem. (1999)
- PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Nuchprayoon, I., Meyers, S., Scott, L.M., Suzow, J., Hiebert, S., Friedman, A.D. Mol. Cell. Biol. (1994)
- Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Shapiro, S.D., Goldstein, N.M., Houghton, A.M., Kobayashi, D.K., Kelley, D., Belaaouaj, A. Am. J. Pathol. (2003)
- PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration. Wang, S., Dangerfield, J.P., Young, R.E., Nourshargh, S. J. Cell. Sci. (2005)
- Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models. Lucattelli, M., Bartalesi, B., Cavarra, E., Fineschi, S., Lunghi, B., Martorana, P.A., Lungarella, G. Respir. Res. (2005)
- Leukotrienes are involved in leukocyte recruitment induced by live Histoplasma capsulatum or by the beta-glucan present in their cell wall. Medeiros, A.I., Silva, C.L., Malheiro, A., Maffei, C.M., Faccioli, L.H. Br. J. Pharmacol. (1999)
- Characterization of the murine macrophage receptor for group B streptococci. Sloan, A.R., Pistole, T.G. Zentralbl. Bakteriol. (1993)
- C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Oelgeschläger, M., Nuchprayoon, I., Lüscher, B., Friedman, A.D. Mol. Cell. Biol. (1996)
- Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells. Terui, T., Sano, K., Okada, M., Shirota, H., Honda, M., Ozawa, M., Hirasawa, N., Tamura, G., Tagami, H. J. Invest. Dermatol. (2001)
- Neutrophil elastase enhances macrophage production of chemokines in receptor-mediated reaction. Ishihara, K., Yamaguchi, Y., Okabe, K., Ogawa, M. Res. Commun. Mol. Pathol. Pharmacol. (1999)
- Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. Adkison, A.M., Raptis, S.Z., Kelley, D.G., Pham, C.T. J. Clin. Invest. (2002)
- Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor ONO-5046. Suzuki, K., Nakajima, H., Ikeda, K., Tamachi, T., Hiwasa, T., Saito, Y., Iwamoto, I. Biochem. Biophys. Res. Commun. (2003)
- Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2. Li, F.Q., Person, R.E., Takemaru, K., Williams, K., Meade-White, K., Ozsahin, A.H., Güngör, T., Moon, R.T., Horwitz, M. J. Biol. Chem. (2004)
- Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Chua, F., Dunsmore, S.E., Clingen, P.H., Mutsaers, S.E., Shapiro, S.D., Segal, A.W., Roes, J., Laurent, G.J. Am. J. Pathol. (2007)
- Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor. Wielockx, B., Bussolino, F., Shapiro, S.D., Libert, C. J. Hepatol. (2001)