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Gene Review

Impdh1  -  inosine 5'-phosphate dehydrogenase 1

Mus musculus

Synonyms: B930086D20Rik, IMP dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I, ...
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Disease relevance of Impdh1


High impact information on Impdh1


Biological context of Impdh1

  • This distinction in regulation pattern suggests that under normal growth conditions, unlike IMPD downregulation, bax and waf1 induction is not a rate-determining event for p53-dependent growth suppression [9].
  • We have documented the presence of multiple, processed pseudogenes of type I IMPDH in human and Rhesus monkey genomic DNA, as well as a single functional gene encoding low levels of type I mRNA in human brain, heart, kidney and placenta [10].
  • Thus, regulation of IMPDH gene expression is mediated at least in part by the bcr-abl gene product and may therefore be indicative of a specific mechanism of intrinsic resistance to tiazofurin [11].
  • The suppressive effects of newly synthesized NAD-analogs, indazole adenine dinucleotides (IAD), on the cellular proliferation of normal and L5178Y cells were investigated in connection with their inhibitory activity on inosine 5'-monophosphate dehydrogenase (IMPD) [12].
  • Thus the inhibition of cell growth is probably due to bredinin 5'-phosphate, which inhibits the consecutive enzyme reactions IMP dehydrogenase and GMP synthetase [13].

Anatomical context of Impdh1


Associations of Impdh1 with chemical compounds


Analytical, diagnostic and therapeutic context of Impdh1

  • Northern blot analysis of chicken RNA revealed a single mRNA species that hybridized to human IMPDH type I and II probes [10].
  • This increase in enzyme activity was a result of 2-fold increased IMPDH protein as determined by immunoblotting [11].


  1. Isolation and sequence of a cDNA encoding mouse IMP dehydrogenase. Tiedeman, A.A., Smith, J.M. Gene (1991) [Pubmed]
  2. Inhibition by tiazofurin of inosine 5'-phosphate dehydrogenase (IMP DH) activity in extracts of ovarian carcinomas. Look, K.Y., Sutton, G.P., Natsumeda, Y., Eble, J.N., Stehman, F.B., Ehrlich, C.E., Olah, E., Prajda, N., Bosze, P., Eckhardt, S. Gynecol. Oncol. (1992) [Pubmed]
  3. Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Barnard, D.L., Day, C.W., Bailey, K., Heiner, M., Montgomery, R., Lauridsen, L., Winslow, S., Hoopes, J., Li, J.K., Lee, J., Carson, D.A., Cottam, H.B., Sidwell, R.W. Antiviral Res. (2006) [Pubmed]
  4. Sensitive radiochemical assay for inosine 5'-monophosphate dehydrogenase and determination of activity in murine tumor and tissue extracts. Proffitt, R.T., Pathak, V.K., Villacorte, D.G., Presant, C.A. Cancer Res. (1983) [Pubmed]
  5. New antitumor imidazole derivative, 5-carbamoyl-1H-imidazol-4-yl piperonylate, as an inhibitor of purine synthesis and its activation by adenine phosphoribosyltransferase. Fukui, M., Inaba, M., Tsukagoshi, S., Sakurai, Y. Cancer Res. (1982) [Pubmed]
  6. Mycophenolate mofetil impairs the maturation and function of murine dendritic cells. Mehling, A., Grabbe, S., Voskort, M., Schwarz, T., Luger, T.A., Beissert, S. J. Immunol. (2000) [Pubmed]
  7. Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation. Liu, Y., Bohn, S.A., Sherley, J.L. Mol. Biol. Cell (1998) [Pubmed]
  8. Combination effect of mycophenolate mofetil with mizoribine on cell proliferation assays and in a mouse heart transplantation model. Shimmura, H., Tanabe, K., Habiro, K., Abe, R., Toma, H. Transplantation (2006) [Pubmed]
  9. Comparison of bax, waf1, and IMP dehydrogenase regulation in response to wild-type p53 expression under normal growth conditions. Liu, Y., Riley, L.B., Bohn, S.A., Boice, J.A., Stadler, P.B., Sherley, J.L. J. Cell. Physiol. (1998) [Pubmed]
  10. Type I inosine monophosphate dehydrogenase: evidence for a single functional gene in mammalian species. Dayton, J.S., Mitchell, B.S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  11. p210 bcr-abl confers overexpression of inosine monophosphate dehydrogenase: an intrinsic pathway to drug resistance mediated by oncogene. Gharehbaghi, K., Burgess, G.S., Collart, F.R., Litz-Jackson, S., Huberman, E., Jayaram, H.N., Boswell, H.S. Leukemia (1994) [Pubmed]
  12. Suppressive effect of indazole adenine dinucleotides on proliferation of normal and malignant cells. Tono-Oka, S., Tone, Y., Azuma, I. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1986) [Pubmed]
  13. Dual inhibitory effect of bredinin. Kusumi, T., Tsuda, M., Katsunuma, T., Yamamura, M. Cell Biochem. Funct. (1989) [Pubmed]
  14. Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses immunoglobulin and cytokine production of B cells. Jonsson, C.A., Carlsten, H. Int. Immunopharmacol. (2003) [Pubmed]
  15. Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Senda, M., DeLustro, B., Eugui, E., Natsumeda, Y. Transplantation (1995) [Pubmed]
  16. Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide, and LDH in macrophages. Jonsson, C.A., Carlsten, H. Cell. Immunol. (2002) [Pubmed]
  17. Compartmentation of guanine nucleotide precursors for DNA synthesis. Nguyen, B.T., Sadée, W. Biochem. J. (1986) [Pubmed]
  18. Studies on the mechanism of action of tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide). VI. Biochemical and pharmacological studies on the degradation of thiazole-4-carboxamide adenine dinucleotide (TAD). Ahluwalia, G.S., Cooney, D.A., Marquez, V.E., Jayaram, H.N., Johns, D.G. Biochem. Pharmacol. (1986) [Pubmed]
  19. Inosine monophosphate dehydrogenase (IMPDH) inhibition in vitro suppresses lymphocyte proliferation and the production of immunoglobulins, autoantibodies and cytokines in splenocytes from MRLlpr/lpr mice. Jonsson, C.A., Carlsten, H. Clin. Exp. Immunol. (2001) [Pubmed]
  20. Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity. Cooney, D.A., Jayaram, H.N., Glazer, R.I., Kelley, J.A., Marquez, V.E., Gebeyehu, G., Van Cott, A.C., Zwelling, L.A., Johns, D.G. Adv. Enzyme Regul. (1983) [Pubmed]
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