The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Bredinin     1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Bredinine, Mizoribina, mizoribine, Mizoribinum, Bredinin (TN), ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of mizoribine


High impact information on mizoribine

  • To further characterize the mechanism of action of this drug, we studied the effect of mizoribine on human peripheral blood T cells stimulated with alloantigen, anti-CD3 MAb, or pharmacologic mitogens [6].
  • Based on studies in cell lines, mizoribine has been postulated to be an inhibitor of inosine monophosphate (IMP) dehydrogenase (EC1.2.1.14), a pivotal enzyme in the formation of guanine ribonucleotides from IMP [6].
  • Measurements of purine ribonucleotide pools by HPLC showed that mizoribine led to a decrease in intracellular GTP levels, and that repletion of GTP reversed its antiproliferative effects [6].
  • Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine [6].
  • Inhibition by bredinin at a low GMP; but at higher concentrations of bredinin the inhibition was not reversed even when the concentration of GMP was raised [1].

Chemical compound and disease context of mizoribine


Biological context of mizoribine


Anatomical context of mizoribine


Associations of mizoribine with other chemical compounds


Gene context of mizoribine


Analytical, diagnostic and therapeutic context of mizoribine


  1. Action of bredinin on mammalian cells. Sakaguchi, K., Tsujino, M., Yoshizawa, M., Mizuno, K., Hayano, K. Cancer Res. (1975) [Pubmed]
  2. Antitumor activities of newly synthesized 5-carbamoyl-1 H-imidazol-4yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4yl piperonylate. Yoshida, N., Kiyohara, T., Fukui, M., Atsumi, T., Ogino, S., Inaba, M., Tsukagoshi, S., Sakurai, Y. Cancer Res. (1980) [Pubmed]
  3. Biochemical mode of cytotoxic action of neplanocin A in L1210 leukemic cells. Inaba, M., Nagashima, K., Tsukagoshi, S., Sakurai, Y. Cancer Res. (1986) [Pubmed]
  4. A multicenter trial of mizoribine compared with placebo in children with frequently relapsing nephrotic syndrome. Yoshioka, K., Ohashi, Y., Sakai, T., Ito, H., Yoshikawa, N., Nakamura, H., Tanizawa, T., Wada, H., Maki, S. Kidney Int. (2000) [Pubmed]
  5. Effects of combination cyclosporine/mizoribine immunosuppression on canine renal allograft recipients. Gregory, C.R., Gourley, I.M., Cain, G.R., Broaddus, T.W., Cowgill, L.D., Willits, N.H., Patz, J.D., Ishizaki, G. Transplantation (1988) [Pubmed]
  6. Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine. Turka, L.A., Dayton, J., Sinclair, G., Thompson, C.B., Mitchell, B.S. J. Clin. Invest. (1991) [Pubmed]
  7. Mizoribine improves renal tubulointerstitial fibrosis in unilateral ureteral obstruction (UUO)-treated rat by inhibiting the infiltration of macrophages and the expression of alpha-smooth muscle actin. Sakai, T., Kawamura, T., Shirasawa, T. J. Urol. (1997) [Pubmed]
  8. Oral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome. Kawasaki, Y., Hosoya, M., Kobayashi, S., Ohara, S., Onishi, N., Takahashi, A., Isome, M., Suzuki, H. Nephrol. Dial. Transplant. (2005) [Pubmed]
  9. Steroid-sparing effect of mizoribine in long-term nephrotic syndrome of children. Igarashi, Y., Moro, Y., Kondo, Y., Inoue, C.N. Pediatr. Nephrol. (1994) [Pubmed]
  10. Studies on antinephritic effect of mizoribine (p-INN, Bredinin), a new immunosuppressive agent, and azathioprine (1) effect on the nephrotic type of anti-GBM nephritis in rats. Okamoto, K., Ito, M., Suzuki, Y. Jpn. J. Pharmacol. (1983) [Pubmed]
  11. Inhibition of expression of cyclin A in human B cells by an immunosuppressant mizoribine. Hirohata, S., Yanagida, T. J. Immunol. (1995) [Pubmed]
  12. Mammalian HSP60 is a major target for an immunosuppressant mizoribine. Itoh, H., Komatsuda, A., Wakui, H., Miura, A.B., Tashima, Y. J. Biol. Chem. (1999) [Pubmed]
  13. GTP depletion induced by IMP dehydrogenase inhibitors blocks RNA-primed DNA synthesis. Catapano, C.V., Dayton, J.S., Mitchell, B.S., Fernandes, D.J. Mol. Pharmacol. (1995) [Pubmed]
  14. Mizoribine pharmacokinetics and pharmacodynamics in a canine renal allograft model of local immunosuppression. Gruber, S.A., Erdmann, G.R., Burke, B.A., Moss, A., Bowers, L., Hrushesky, W.J., Cipolle, R.J., Canafax, D.M., Matas, A.J. Transplantation (1992) [Pubmed]
  15. Maintenance of murine oocyte meiotic arrest: uptake and metabolism of hypoxanthine and adenosine by cumulus cell-enclosed and denuded oocytes. Downs, S.M., Coleman, D.L., Eppig, J.J. Dev. Biol. (1986) [Pubmed]
  16. Differentiation induction in non-lymphocytic leukemia cells upon treatment with mizoribine. Inai, K., Tsutani, H., Yamauchi, T., Huberman, E., Nakamura, T., Ueda, T. Int. J. Hematol. (1997) [Pubmed]
  17. Combination effect of mycophenolate mofetil with mizoribine on cell proliferation assays and in a mouse heart transplantation model. Shimmura, H., Tanabe, K., Habiro, K., Abe, R., Toma, H. Transplantation (2006) [Pubmed]
  18. Surgical complications of pediatric kidney transplantation: a single center experience with the extraperitoneal technique. Tanabe, K., Takahashi, K., Kawaguchi, H., Ito, K., Yamazaki, Y., Toma, H. J. Urol. (1998) [Pubmed]
  19. Genetic variation and dynamics of hepatitis C virus replicons in long-term cell culture. Kato, N., Nakamura, T., Dansako, H., Namba, K., Abe, K., Nozaki, A., Naka, K., Ikeda, M., Shimotohno, K. J. Gen. Virol. (2005) [Pubmed]
  20. Differential cytotoxic effects of mizoribine and its aglycone on human and murine cells and on normal and enzyme-deficient human cells. Terai, C., Hakoda, M., Yamanaka, H., Kamatani, N., Kashiwazaki, S. Biochem. Pharmacol. (1995) [Pubmed]
  21. Inhibitory effect of mizoribine on matrix metalloproteinase-1 production in synovial fibroblasts and THP-1 macrophages. Zhong, B., Tajima, M., Takahara, H., Nochi, H., Tamoto, K., Tamura, N., Kobayashi, S., Tamura, Y., Ikeda, M., Akimoto, T., Yoshino, S., Hashimoto, H. Modern rheumatology / the Japan Rheumatism Association. (2005) [Pubmed]
  22. Inhibition of cyclin A gene expression in human B cells by an immunosuppressant mizoribine. Hirohata, S., Nakanishi, K., Yanagida, T. Clin. Exp. Immunol. (2000) [Pubmed]
  23. The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase. Köhler, G.A., Gong, X., Bentink, S., Theiss, S., Pagani, G.M., Agabian, N., Hedstrom, L. J. Biol. Chem. (2005) [Pubmed]
  24. Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation. Tanabe, M., Todo, S., Murase, N., Irish, W., Miyazawa, H., Fujisaki, S., Starzl, T.E. Transplantation (1994) [Pubmed]
  25. Mizoribine serum levels associated with enterotoxicity in the dog. Gregory, C.R., Gourley, I.M., Cain, G.R., Patz, J.D., Imondi, K.A., Martin, J.A. Transplantation (1991) [Pubmed]
WikiGenes - Universities