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MeSH Review

Rats, Inbred Dahl

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Disease relevance of Rats, Inbred Dahl


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Chemical compound and disease context of Rats, Inbred Dahl


Biological context of Rats, Inbred Dahl


Anatomical context of Rats, Inbred Dahl


Associations of Rats, Inbred Dahl with chemical compounds

  • Dahl salt-sensitive rats (n = 6 per group) on standard or salt-enriched chow were treated for 8 wk with O (36 +/- 4 mg/kg per d), C (94 +/- 2 mg/kg per d), or placebo [25].
  • METHODS: Dahl salt-sensitive rats fed a high-salt diet for seven weeks were divided into three groups: eight untreated rats (DHF group), eight rats given high-dose amlodipine (10 mg/kg/day; HDA group) and seven rats given low-dose amlodipine (1 mg/kg/day; LDA group) [26].
  • Salt-sensitive (DS) and salt-resistant (DR) Dahl rats were treated for 8 wk with high salt diet (4% NaCl) alone or in combination with the ET(A) receptor antagonist LU135252 (60 mg/kg per d) [27].
  • To test this hypothesis in Dahl salt-sensitive rats given sodium chloride (4%) for 3 weeks, we supplemented dietary potassium (2.1%) with either KCl (n = 16) or KHCO3 (n = 16) [28].
  • Failure of salt loading to inhibit tissue norepinephrine turnover in prehypertensive Dahl salt-sensitive rats [29].

Gene context of Rats, Inbred Dahl


Analytical, diagnostic and therapeutic context of Rats, Inbred Dahl


  1. Dopamine D(3) receptors and salt-dependent hypertension. Luippold, G., Zimmermann, C., Mai, M., Kloor, D., Starck, D., Gross, G., Mühlbauer, B. J. Am. Soc. Nephrol. (2001) [Pubmed]
  2. Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension. Böhm, M., Gierschik, P., Knorr, A., Schmidt, U., Weismann, K., Erdmann, E. Hypertension (1993) [Pubmed]
  3. Dissociation of renal nerve and excretory responses to volume expansion in prehypertensive Dahl salt-sensitive and Dahl salt-resistant rats. Veelken, R., Sawin, L.L., DiBona, G.F. Hypertension (1989) [Pubmed]
  4. Influence of cadmium on two-kidney Goldblatt hypertension in Dahl rats. Ohanian, E.V., Heine, M., Iwai, J. Proc. Soc. Exp. Biol. Med. (1978) [Pubmed]
  5. Involvement of angiotensin II in development of spontaneous nephrosis in Dahl salt-sensitive rats. Yoneda, H., Toriumi, W., Ohmachi, Y., Okumura, F., Fujimura, H., Nishiyama, S. Eur. J. Pharmacol. (1998) [Pubmed]
  6. The influence of the renin gene on alcohol consumption in Dahl rats. O'Dowd, B.F., Grupp, L.A. Alcohol. Clin. Exp. Res. (1991) [Pubmed]
  7. Brain "ouabain" mediates the sympathoexcitatory and hypertensive effects of high sodium intake in Dahl salt-sensitive rats. Huang, B.S., Leenen, F.H. Circ. Res. (1994) [Pubmed]
  8. Mechanism of impaired baroreflex control in prehypertensive Dahl salt-sensitive rats. Gordon, F.J., Mark, A.L. Circ. Res. (1984) [Pubmed]
  9. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett, M.R., Dene, H., Walder, R., Zhang, Q.Y., Cicila, G.T., Assadnia, S., Deng, A.Y., Rapp, J.P. Genome Res. (1998) [Pubmed]
  10. The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats. Nishiyama, A., Yoshizumi, M., Hitomi, H., Kagami, S., Kondo, S., Miyatake, A., Fukunaga, M., Tamaki, T., Kiyomoto, H., Kohno, M., Shokoji, T., Kimura, S., Abe, Y. J. Am. Soc. Nephrol. (2004) [Pubmed]
  11. Renal intramedullary infusion of L-arginine prevents reduction of medullary blood flow and hypertension in Dahl salt-sensitive rats. Miyata, N., Cowley, A.W. Hypertension (1999) [Pubmed]
  12. Clofibrate prevents the development of hypertension in Dahl salt-sensitive rats. Roman, R.J., Ma, Y.H., Frohlich, B., Markham, B. Hypertension (1993) [Pubmed]
  13. Role of epinephrine in the development of hypertension in Dahl salt-sensitive rats. Johnson, M.D., Kotchen, T.A. Hypertension (1990) [Pubmed]
  14. Taurine amplifies renal kallikrein and prevents salt-induced hypertension in Dahl rats. Ideishi, M., Miura, S., Sakai, T., Sasaguri, M., Misumi, Y., Arakawa, K. J. Hypertens. (1994) [Pubmed]
  15. Erythrocyte membrane microviscosity and blood pressure in rats with salt-induced and spontaneous hypertension. Kunes, J., Zicha, J., Devynck, M.A. J. Hypertens. (1994) [Pubmed]
  16. Structural differences in the renin gene of Dahl salt-sensitive and salt-resistant rats. Wang, S.M., Rapp, J.P. Mol. Endocrinol. (1989) [Pubmed]
  17. L-arginine administration normalizes pressure natriuresis in hypertensive Dahl rats. Patel, A., Layne, S., Watts, D., Kirchner, K.A. Hypertension (1993) [Pubmed]
  18. Brain 'ouabain' and desensitization of arterial baroreflex by high sodium in Dahl salt-sensitive rats. Huang, B.S., Leenen, F.H. Hypertension (1995) [Pubmed]
  19. Angiotensin II-induced protein phosphorylation in the hypertrophic heart of the Dahl rat. Sunga, P.S., Rabkin, S.W. Hypertension (1992) [Pubmed]
  20. Overexpression of chloride channel CLC-K2 mRNA in the renal medulla of Dahl salt-sensitive rats. Castrop, H., Krämer, B.K., Riegger, G.A., Kurtz, A., Wolf, K. J. Hypertens. (2000) [Pubmed]
  21. Deuterium oxide normalizes blood pressure and vascular calcium uptake in Dahl salt-sensitive hypertensive rats. Vasdev, S., Prabhakaran, V., Sampson, C.A. Hypertension (1990) [Pubmed]
  22. Enhanced chloride reabsorption in the loop of Henle in Dahl salt-sensitive rats. Roman, R.J., Kaldunski, M.L. Hypertension (1991) [Pubmed]
  23. Carotid artery mechanical properties of Dahl salt-sensitive rats. Benetos, A., Bouaziz, H., Albaladejo, P., Guez, D., Safar, M.E. Hypertension (1995) [Pubmed]
  24. Abnormalities of carbohydrate and lipid metabolism in Dahl rats. Reaven, G.M., Twersky, J., Chang, H. Hypertension (1991) [Pubmed]
  25. Vasopeptidase inhibition restores renovascular endothelial dysfunction in salt-induced hypertension. Quaschning, T., D'Uscio, L.V., Shaw, S., Gröne, H.J., Ruschitzka, F., Lüscher, T.F. J. Am. Soc. Nephrol. (2001) [Pubmed]
  26. Long-term administration of amlodipine prevents decompensation to diastolic heart failure in hypertensive rats. Nishikawa, N., Masuyama, T., Yamamoto, K., Sakata, Y., Mano, T., Miwa, T., Sugawara, M., Hori, M. J. Am. Coll. Cardiol. (2001) [Pubmed]
  27. Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophyandGlomerulosclerosis. Barton, M., Vos, I., Shaw, S., Boer, P., D'Uscio, L.V., Gröne, H.J., Rabelink, T.J., Lattmann, T., Moreau, P., Lüscher, T.F. J. Am. Soc. Nephrol. (2000) [Pubmed]
  28. Potassium preserves endothelial function and enhances aortic compliance in Dahl rats. Sudhir, K., Kurtz, T.W., Yock, P.G., Connolly, A.J., Morris, R.C. Hypertension (1993) [Pubmed]
  29. Failure of salt loading to inhibit tissue norepinephrine turnover in prehypertensive Dahl salt-sensitive rats. Genain, C.P., Reddy, S.R., Ott, C.E., Van Loon, G.R., Kotchen, T.A. Hypertension (1988) [Pubmed]
  30. Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats. Nishiyama, A., Yoshizumi, M., Rahman, M., Kobori, H., Seth, D.M., Miyatake, A., Zhang, G.X., Yao, L., Hitomi, H., Shokoji, T., Kiyomoto, H., Kimura, S., Tamaki, T., Kohno, M., Abe, Y. Kidney Int. (2004) [Pubmed]
  31. Marked reduction of mortality in salt-loaded Dahl salt-sensitive rats by the new, selective endothelin ETA receptor antagonist, J-105859. Okada, M., Nishino, M., Saito, M., Ikeda, T., Uehara, S., Okada, H., Niiyama, K., Ohtake, N., Hayama, T., Nishikibe, M. J. Hypertens. (2000) [Pubmed]
  32. Differential nNOS gene expression in salt-sensitive and salt-resistant Dahl rats. Castrop, H., Kurtz, A. J. Hypertens. (2001) [Pubmed]
  33. Decreased expression of arginase II in the kidneys of Dahl salt-sensitive rats. Iwata, S., Tsujino, T., Ikeda, Y., Ishida, T., Ueyama, T., Gotoh, T., Mori, M., Yokoyama, M. Hypertens. Res. (2002) [Pubmed]
  34. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai, N., Yasui, N., Naraba, H., Tago, N., Yamawaki, H., Sumiya, H. Hypertension (2005) [Pubmed]
  35. Subcellular membrane properties in vascular and non-vascular smooth muscles of Dahl hypertensive rats. Kwan, C.Y., Triggle, C.R., Grover, A.K., Daniel, E.E. J. Hypertens. (1986) [Pubmed]
  36. Effects of imidapril on endothelin-1 and ACE gene expression in failing hearts of salt-sensitive hypertensive rats. Kobayashi, N., Hara, K., Higashi, T., Matsuoka, H. Am. J. Hypertens. (2000) [Pubmed]
  37. Down-regulation of calpain 9 is linked to hypertensive heart and kidney disease. Markmann, A., Schäfer, S., Linz, W., Löhn, M., Busch, A.E., Wohlfart, P. Cell. Physiol. Biochem. (2005) [Pubmed]
  38. Probucol suppresses the development of chronic renal failure in Dahl salt-sensitive rats: an animal model of spontaneous focal and segmental glomerulosclerosis. Naito, H., Hirano, T. Nephron (1994) [Pubmed]
  39. Progression of glomerulosclerosis, renal hypertrophy, and an increased expression of fibronectin in the renal cortex associated with aging and salt-induced hypertension in Dahl salt-sensitive rats. Takizawa, T., Takasaki, I., Shionoiri, H., Ishii, M. Life Sci. (1997) [Pubmed]
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