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Gene Review

Epor  -  erythropoietin receptor

Rattus norvegicus

Synonyms: EPO-R, Erythropoietin receptor
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Disease relevance of Epor


High impact information on Epor

  • We show that EPOR-mediated activation of Jak2 leads to phosphorylation of the inhibitor of NF-kappaB (IkappaB), subsequent nuclear translocation of the transcription factor NF-kappaB, and NF-kappaB-dependent transcription of neuroprotective genes [6].
  • Unexpectedly, coadministration of MPSS antagonized the protective effects of EPO, even though the EPO receptor was up-regulated normally after injury [7].
  • Modulation of wound healing because of administration of recombinant EPO or inhibition of endogenous EPO-EPO receptor correlated with changes in levels of inducible nitric oxide synthase protein in granulation tissue [8].
  • We also found abundant expression of EPO receptor protein in macrophages, cells that play a pivotal role during wound healing [8].
  • These results suggest that activation of EPO-R suppresses ischemic cell death by inhibiting the exocytosis of Glu [1].

Biological context of Epor


Anatomical context of Epor


Associations of Epor with chemical compounds


Physical interactions of Epor

  • These biological activities were completely inhibited by the anti-Epo antiserum and the extracellular domain of the Epo receptor capable of binding with Epo [16].

Regulatory relationships of Epor

  • Our results suggest a new mechanism for Epo-induced neuroprotection, in which circulating Epo controls and maintains the BBB through an Epo receptor signalling pathway and the re-establishment of cell junctions [17].
  • Immunoanalyses showed that Epo induced a significant increase in phosphorylated Janus kinase 2 and signal transducer and activator of transcription-5 expressions at 1 and 3 d and up-regulated Bcl-xL expression by 24 h after FCI but did not affect Epo receptor or NF-kappaB expression [18].

Other interactions of Epor


Analytical, diagnostic and therapeutic context of Epor


  1. Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia. Kawakami, M., Sekiguchi, M., Sato, K., Kozaki, S., Takahashi, M. J. Biol. Chem. (2001) [Pubmed]
  2. Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain. Wen, T.C., Rogido, M., Genetta, T., Sola, A. Neurosci. Lett. (2004) [Pubmed]
  3. Survival of hippocampal neurons in culture upon hypoxia: effect of erythropoietin. Lewczuk, P., Hasselblatt, M., Kamrowski-Kruck, H., Heyer, A., Unzicker, C., Sirén, A.L., Ehrenreich, H. Neuroreport (2000) [Pubmed]
  4. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. Wright, G.L., Hanlon, P., Amin, K., Steenbergen, C., Murphy, E., Arcasoy, M.O. FASEB J. (2004) [Pubmed]
  5. Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cells. Fujita, M., Takahashi, R., Kitada, K., Watanabe, R., Kitazawa, S., Ashoori, F., Liang, P., Saya, H., Serikawa, T., Maeda, S. Cancer Lett. (1997) [Pubmed]
  6. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Digicaylioglu, M., Lipton, S.A. Nature (2001) [Pubmed]
  7. Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury. Gorio, A., Madaschi, L., Di Stefano, B., Carelli, S., Di Giulio, A.M., De Biasi, S., Coleman, T., Cerami, A., Brines, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  8. A novel role for erythropoietin during fibrin-induced wound-healing response. Haroon, Z.A., Amin, K., Jiang, X., Arcasoy, M.O. Am. J. Pathol. (2003) [Pubmed]
  9. Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity. Hardee, M.E., Rabbani, Z.N., Arcasoy, M.O., Kirkpatrick, J.P., Vujaskovic, Z., Dewhirst, M.W., Blackwell, K.L. Mol. Cancer Ther. (2006) [Pubmed]
  10. Rat thymectomy effects on leptin receptor and T-bet: erythroid hyperplasia with maturation arrest and suppressed T-cell-mediated hepatotoxicity. Nakatsuji, T. Laboratory hematology : official publication of the International Society for Laboratory Hematology. (2006) [Pubmed]
  11. Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells. Yamasaki, M., Mishima, H.K., Yamashita, H., Kashiwagi, K., Murata, K., Minamoto, A., Inaba, T. Brain Res. (2005) [Pubmed]
  12. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Sadamoto, Y., Igase, K., Sakanaka, M., Sato, K., Otsuka, H., Sakaki, S., Masuda, S., Sasaki, R. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  13. Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin. Grasso, G., Sfacteria, A., Passalacqua, M., Morabito, A., Buemi, M., Macrì, B., Brines, M.L., Tomasello, F. Neurosurgery (2005) [Pubmed]
  14. Erythropoietin inhibits calcium-induced neurotransmitter release from clonal neuronal cells. Kawakami, M., Iwasaki, S., Sato, K., Takahashi, M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  15. The effect of erythropoietin on gentamicin-induced auditory hair cell loss. Monge, A., Nagy, I., Bonabi, S., Schmid, S., Gassmann, M., Bodmer, D. Laryngoscope (2006) [Pubmed]
  16. A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. Masuda, S., Okano, M., Yamagishi, K., Nagao, M., Ueda, M., Sasaki, R. J. Biol. Chem. (1994) [Pubmed]
  17. Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability. Martínez-Estrada, O.M., Rodríguez-Millán, E., González-De Vicente, E., Reina, M., Vilaró, S., Fabre, M. Eur. J. Neurosci. (2003) [Pubmed]
  18. Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats. Sola, A., Rogido, M., Lee, B.H., Genetta, T., Wen, T.C. Pediatr. Res. (2005) [Pubmed]
  19. Hypoxia-ischemia affects erythropoietin and erythropoietin receptor expression pattern in the neonatal rat brain. Spandou, E., Papoutsopoulou, S., Soubasi, V., Karkavelas, G., Simeonidou, C., Kremenopoulos, G., Guiba-Tziampiri, O. Brain Res. (2004) [Pubmed]
  20. Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats. Böcker-Meffert, S., Rosenstiel, P., Röhl, C., Warneke, N., Held-Feindt, J., Sievers, J., Lucius, R. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
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