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Ptprz1  -  protein tyrosine phosphatase, receptor...

Rattus norvegicus

Synonyms: 3F8 chondroitin sulfate proteoglycan, 3H1 keratan sulfate proteoglycan, PTPzeta-A, PTPzeta-B, PTPzeta-S, ...
 
 
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Disease relevance of Ptprz1

  • C6 glioma cells, which express phosphacan, adhered to dishes coated with Ng-CAM, and low concentrations of phosphacan inhibited adhesion to Ng-CAM but not to laminin and fibronectin [1].
  • Phosphacan inhibited adhesion and axonal extension of cerebellar granule cells in dissociated culture, while it promoted axonal fasciculation of their aggregated culture [2].
  • Surprisingly, the immunohistologic staining for phosphacan was conversely intensified both at 24 hr and 8 days after hypoxia at the infarcted area [3].
  • Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro [4].
  • Comparison of RPTP zeta/beta, phosphacan, and trkB mRNA expression in the developing and adult rat nervous system and induction of RPTP zeta/beta and phosphacan mRNA following brain injury [5].
 

High impact information on Ptprz1

 

Chemical compound and disease context of Ptprz1

 

Biological context of Ptprz1

 

Anatomical context of Ptprz1

 

Associations of Ptprz1 with chemical compounds

 

Physical interactions of Ptprz1

 

Other interactions of Ptprz1

  • Immunocytochemical studies of early postnatal rat cerebellum demonstrated that the localization of neurocan, phosphacan, and phosphacan-KS all overlap extensively with that of tenascin, an extracellular matrix protein that modulates cell adhesion and migration [9].
  • A solid phase radioligand binding assay confirmed that neurocan, phosphacan, and phosphacan-KS bind to tenascin but not to laminin and fibronectin [9].
  • These analyses showed that treatment of astrocytes with EGF increased phosphacan expression, whereas treatment with TGF-beta1 increased neurocan expression [16].
  • The present results indicate the high expression of the CSPG, phosphacan/RPTPbeta at the extracellular space in the hypothalamic AVP- and OXT-secreting magnocellular neurons [17].
  • Digestions with chondroitinase ABC and hyaluronidase indicated that aggrecan, versican, neurocan, brevican, and phosphacan are retained in PNNs through binding to hyaluronan (HA) [18].
 

Analytical, diagnostic and therapeutic context of Ptprz1

References

  1. Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules. Milev, P., Friedlander, D.R., Sakurai, T., Karthikeyan, L., Flad, M., Margolis, R.K., Grumet, M., Margolis, R.U. J. Cell Biol. (1994) [Pubmed]
  2. Chondroitin sulfate proteoglycan phosphacan associates with parallel fibers and modulates axonal extension and fasciculation of cerebellar granule cells. Hayashi, N., Mizusaki, M.J., Kamei, K., Harada, S., Miyata, S. Mol. Cell. Neurosci. (2005) [Pubmed]
  3. Changes in the amounts of chondroitin sulfate proteoglycans in rat brain after neonatal hypoxia-ischemia. Matsui, F., Kakizawa, H., Nishizuka, M., Hirano, K., Shuo, T., Ida, M., Tokita, Y., Aono, S., Keino, H., Oohira, A. J. Neurosci. Res. (2005) [Pubmed]
  4. Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro. Sango, K., Oohira, A., Ajiki, K., Tokashiki, A., Horie, M., Kawano, H. Exp. Neurol. (2003) [Pubmed]
  5. Comparison of RPTP zeta/beta, phosphacan, and trkB mRNA expression in the developing and adult rat nervous system and induction of RPTP zeta/beta and phosphacan mRNA following brain injury. Snyder, S.E., Li, J., Schauwecker, P.E., McNeill, T.H., Salton, S.R. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  6. Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Maurel, P., Rauch, U., Flad, M., Margolis, R.K., Margolis, R.U. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin. Milev, P., Meyer-Puttlitz, B., Margolis, R.K., Margolis, R.U. J. Biol. Chem. (1995) [Pubmed]
  8. Chondroitin sulfate proteoglycans in the developing central nervous system. I. cellular sites of synthesis of neurocan and phosphacan. Engel, M., Maurel, P., Margolis, R.U., Margolis, R.K. J. Comp. Neurol. (1996) [Pubmed]
  9. Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue. Grumet, M., Milev, P., Sakurai, T., Karthikeyan, L., Bourdon, M., Margolis, R.K., Margolis, R.U. J. Biol. Chem. (1994) [Pubmed]
  10. Chondroitin sulfate proteoglycans in the developing central nervous system. II. Immunocytochemical localization of neurocan and phosphacan. Meyer-Puttlitz, B., Junker, E., Margolis, R.U., Margolis, R.K. J. Comp. Neurol. (1996) [Pubmed]
  11. The core protein of the chondroitin sulfate proteoglycan phosphacan is a high-affinity ligand of fibroblast growth factor-2 and potentiates its mitogenic activity. Milev, P., Monnerie, H., Popp, S., Margolis, R.K., Margolis, R.U. J. Biol. Chem. (1998) [Pubmed]
  12. Regulation of RPTPbeta/phosphacan expression and glycosaminoglycan epitopes in injured brain and cytokine-treated glia. Dobbertin, A., Rhodes, K.E., Garwood, J., Properzi, F., Heck, N., Rogers, J.H., Fawcett, J.W., Faissner, A. Mol. Cell. Neurosci. (2003) [Pubmed]
  13. Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture. Inatani, M., Honjo, M., Otori, Y., Oohira, A., Kido, N., Tano, Y., Honda, Y., Tanihara, H. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  14. Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures. Okamoto, M., Sakiyama, J., Mori, S., Kurazono, S., Usui, S., Hasegawa, M., Oohira, A. Exp. Neurol. (2003) [Pubmed]
  15. Isoaspartate in chrondroitin sulfate proteoglycans of mammalian brain. David, C.L., Orpiszewski, J., Zhu, X.C., Reissner, K.J., Aswad, D.W. J. Biol. Chem. (1998) [Pubmed]
  16. Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes. Smith, G.M., Strunz, C. Glia (2005) [Pubmed]
  17. Chondroitin sulfate proteoglycan phosphacan/RPTPbeta in the hypothalamic magnocellular nuclei. Miyata, S., Shinga, I., Taguchi, K., Nakashima, T., Kiyohara, T., Oohira, A. Brain Res. (2002) [Pubmed]
  18. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. Deepa, S.S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., Fawcett, J.W. J. Biol. Chem. (2006) [Pubmed]
 
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