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Nr5a1  -  nuclear receptor subfamily 5, group A,...

Rattus norvegicus

Synonyms: Ad4BP/SF-1, Ad4bp, Adrenal 4-binding protein, Ftzf1, Fushi tarazu factor homolog 1, ...
 
 
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Disease relevance of Nr5a1

  • Recombinant rat SF-1 protein expressed in Escherichia coli binds to this sequence, and antibodies raised against rat SF-1 abolish binding of both recombinant SF-1 and the nuclear protein from Y-1 and MA-10 cells [1].
 

High impact information on Nr5a1

  • Gel shift experiments indicate the specific binding of the SF-1 and a potential SF-1-interacting factor to PARE I while a protein immunologically related to the cyclic AMP response element-binding protein interacts with PARE II [2].
  • Altogether, these data establish the importance of the GnSE in the GnRH-R gene expression and reveal a novel role for SF-1 as a mediator of enhancer activity, a mechanism that might regulate other SF-1 target genes [3].
  • We show that the GnSE activity (-1,135/-753) is mediated through a functional interaction with a proximal region (-275/-226) that includes the SF-1 response element [3].
  • Transfection assays using an artificial promoter containing two SF-1 elements fused to a minimal PRL promoter indicate that SF-1 is crucial in this interaction [3].
  • Proximal cis-acting elements, including steroidogenic factor 1, mediate the efficiency of a distal enhancer in the promoter of the rat gonadotropin-releasing hormone receptor gene [3].
 

Biological context of Nr5a1

  • Stable transfection of murine MSCs with a transcription factor, steroidogenic factor-1, followed by treatment with cAMP almost recapitulated the properties of Leydig cells, including the production of testosterone [4].
  • It is conceivable that the observed effects of DEHP on the expression of nuclear receptors SF-1 and PPARgamma are involved in the downregulation of steroidogenic factors and testosterone levels and thereby underlie the disturbed development of the male reproductive system [5].
  • The significance of SF-1 in regulating target gene activation was supported by EMSA [6].
  • Steroidogenic factor-1 (SF-1) (NR5A1) is an orphan nuclear receptor that plays a premier role in ovarian organogenesis [6].
  • Changes in the spacing between the upstream Sp1 binding sites and the downstream SF-1/Egr-1 binding elements reduce the response to GnRH [7].
 

Anatomical context of Nr5a1

 

Associations of Nr5a1 with chemical compounds

  • Additionally, we observed reduced mRNA expression of the nuclear receptor SF-1, which regulates certain steps in steroid synthesis, and reduced expression of the cryptorchidism-associated Insl-3 [5].
  • The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3',5'-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase) [1].
  • It is further shown that SF-1 can be phosphorylated in vitro by protein kinase A. This phosphorylation occurs at serine and threonine residues and results in decreased binding to the rP450c17 -58/-69 element [1].
  • One, which we designated SF1, is a ubiquitous basal factor, and the other, SF2, is a T-cell-predominant phorbol myristate acetate-inducible factor [10].
  • Polyphosphoinositides:stimulator of mitochondrial cholesterol side chain cleavage and possible identification as an adrenocorticotropin-induced, cycloheximide-sensitive, cytosolic, steroidogenic factor [11].
 

Physical interactions of Nr5a1

 

Regulatory relationships of Nr5a1

 

Other interactions of Nr5a1

 

Analytical, diagnostic and therapeutic context of Nr5a1

References

  1. The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3',5'-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17 alpha-hydroxylase/c17-20 lyase). Zhang, P., Mellon, S.H. Mol. Endocrinol. (1996) [Pubmed]
  2. Pituitary adenylate cyclase-activating polypeptide and cyclic adenosine 3',5'-monophosphate stimulate the promoter activity of the rat gonadotropin-releasing hormone receptor gene via a bipartite response element in gonadotrope-derived cells. Pincas, H., Laverrière, J.N., Counis, R. J. Biol. Chem. (2001) [Pubmed]
  3. Proximal cis-acting elements, including steroidogenic factor 1, mediate the efficiency of a distal enhancer in the promoter of the rat gonadotropin-releasing hormone receptor gene. Pincas, H., Amoyel, K., Counis, R., Laverrière, J.N. Mol. Endocrinol. (2001) [Pubmed]
  4. Differentiation of adult stem cells derived from bone marrow stroma into Leydig or adrenocortical cells. Yazawa, T., Mizutani, T., Yamada, K., Kawata, H., Sekiguchi, T., Yoshino, M., Kajitani, T., Shou, Z., Umezawa, A., Miyamoto, K. Endocrinology (2006) [Pubmed]
  5. Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis. Borch, J., Metzdorff, S.B., Vinggaard, A.M., Brokken, L., Dalgaard, M. Toxicology (2006) [Pubmed]
  6. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Falender, A.E., Lanz, R., Malenfant, D., Belanger, L., Richards, J.S. Endocrinology (2003) [Pubmed]
  7. Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1. Kaiser, U.B., Halvorson, L.M., Chen, M.T. Mol. Endocrinol. (2000) [Pubmed]
  8. Modulation of endogenous GATA-4 activity reveals its dual contribution to Müllerian inhibiting substance gene transcription in Sertoli cells. Tremblay, J.J., Robert, N.M., Viger, R.S. Mol. Endocrinol. (2001) [Pubmed]
  9. Steroidogenic factor-1 expression in marmoset and rat hippocampus: co-localization with StAR and aromatase. Wehrenberg, U., Prange-Kiel, J., Rune, G.M. J. Neurochem. (2001) [Pubmed]
  10. Nuclear factors that bind two regions important to transcriptional activity of the simian immunodeficiency virus long terminal repeat. Winandy, S., Renjifo, B., Li, Y., Hopkins, N. J. Virol. (1992) [Pubmed]
  11. Polyphosphoinositides:stimulator of mitochondrial cholesterol side chain cleavage and possible identification as an adrenocorticotropin-induced, cycloheximide-sensitive, cytosolic, steroidogenic factor. Farese, R.V., Sabir, A.M. Endocrinology (1980) [Pubmed]
  12. Characterization of a steroidogenic factor-1-binding site found in promoter of sterol carrier protein-2 gene. Lopez, D., Shea-Eaton, W., McLean, M.P. Endocrine (2001) [Pubmed]
  13. Functional interactions, phosphorylation, and levels of 3',5'-cyclic adenosine monophosphate-regulatory element binding protein and steroidogenic factor-1 mediate hormone-regulated and constitutive expression of aromatase in gonadal cells. Carlone, D.L., Richards, J.S. Mol. Endocrinol. (1997) [Pubmed]
  14. Steroidogenic factor-1 expression is transiently repressed and c-myc expression and deoxyribonucleic acid synthesis are induced in rat granulosa cells during the periovulatory period. Agarwal, P., Peluso, J.J., White, B.A. Biol. Reprod. (1996) [Pubmed]
  15. Gonadotropin-releasing hormone activation of c-jun, but not early growth response factor-1, stimulates transcription of a luteinizing hormone beta-subunit gene. Melamed, P., Zhu, Y., Tan, S.H., Xie, M., Koh, M. Endocrinology (2006) [Pubmed]
  16. Sterol regulatory element-binding protein-1a binds to cis elements in the promoter of the rat high density lipoprotein receptor SR-BI gene. Lopez, D., McLean, M.P. Endocrinology (1999) [Pubmed]
  17. Increased expression of Müllerian-inhibiting substance correlates with inhibition of follicular growth in the developing ovary of rats treated with E2 benzoate. Ikeda, Y., Nagai, A., Ikeda, M.A., Hayashi, S. Endocrinology (2002) [Pubmed]
  18. Steroidogenic factor-1 regulates the rate of proliferation of normal and neoplastic rat ovarian surface epithelial cells in vitro. Nash, D.M., Hess, S.A., White, B.A., Peluso, J.J. Endocrinology (1998) [Pubmed]
  19. Sterol regulatory element binding protein-1a regulation of the steroidogenic acute regulatory protein gene. Shea-Eaton, W.K., Trinidad, M.J., Lopez, D., Nackley, A., McLean, M.P. Endocrinology (2001) [Pubmed]
  20. Expression of the orphan receptor steroidogenic factor-1 mRNA in the rat medial basal hypothalamus. Roselli, C.E., Jorgensen, E.Z., Doyle, M.W., Rønnekleiv, O.K. Brain Res. Mol. Brain Res. (1997) [Pubmed]
 
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