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Gene Review

FTCD  -  formimidoyltransferase cyclodeaminase

Homo sapiens

Synonyms: Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, LCHC1
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Disease relevance of FTCD


High impact information on FTCD


Biological context of FTCD


Anatomical context of FTCD


Associations of FTCD with chemical compounds


Other interactions of FTCD


Analytical, diagnostic and therapeutic context of FTCD


  1. A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules. Hennig, D., Scales, S.J., Moreau, A., Murley, L.L., De Mey, J., Kreis, T.E. J. Biol. Chem. (1998) [Pubmed]
  2. Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein. Vitozzi, S., Lapierre, P., Djilali-Saiah, I., Alvarez, F. J. Immunol. Methods (2002) [Pubmed]
  3. Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer. Mao, Y., Vyas, N.K., Vyas, M.N., Chen, D.H., Ludtke, S.J., Chiu, W., Quiocho, F.A. EMBO J. (2004) [Pubmed]
  4. A murine model of type 2 autoimmune hepatitis: Xenoimmunization with human antigens. Lapierre, P., Djilali-Saiah, I., Vitozzi, S., Alvarez, F. Hepatology (2004) [Pubmed]
  5. Distinct epitopes on formiminotransferase cyclodeaminase induce autoimmune liver cytosol antibody type 1. Muratori, L., Sztul, E., Muratori, P., Gao , Y., Ripalti, A., Ponti, C., Lenzi, M., Landini, M.P., Bianchi, F.B. Hepatology (2001) [Pubmed]
  6. Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency. Solans, A., Estivill, X., de la Luna, S. Cytogenet. Cell Genet. (2000) [Pubmed]
  7. Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome. Hagiwara, H., Tajika, Y., Matsuzaki, T., Suzuki, T., Aoki, T., Takata, K. Histochem. Cell Biol. (2006) [Pubmed]
  8. The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme. Kohls, D., Sulea, T., Purisima, E.O., MacKenzie, R.E., Vrielink, A. Structure (2000) [Pubmed]
  9. Characterization of the B cell response of patients with anti-liver cytosol autoantibodies in type 2 autoimmune hepatitis. Lapierre, P., Johanet, C., Alvarez, F. Eur. J. Immunol. (2003) [Pubmed]
  10. The effect of T cell depletion with Campath-1M on immune reconstitution after chemotherapy and allogeneic bone marrow transplant as treatment for leukaemia. Lowdell, M.W., Craston, R., Ray, N., Koh, M., Galatowicz, G., Prentice, H.G. Bone Marrow Transplant. (1998) [Pubmed]
  11. Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis. Renous, R., Lapierre, P., Djilali-Saiah, I., Vitozzi, S., Alvarez, F. Exp. Cell Res. (2004) [Pubmed]
  12. Dissociation of the octameric bifunctional enzyme formiminotransferase-cyclodeaminase in urea. Isolation of two monofunctional dimers. Findlay, W.A., MacKenzie, R.E. Biochemistry (1987) [Pubmed]
  13. Renaturation of formiminotransferase-cyclodeaminase from guanidine hydrochloride. Quaternary structure requirements for the activities and polyglutamate specificity. Findlay, W.A., MacKenzie, R.E. Biochemistry (1988) [Pubmed]
  14. Crystallization and preliminary X-ray analysis of the formiminotransferase domain from the bifunctional enzyme formiminotransferase-cyclodeaminase. Kohls, D., Croteau, N., Mejia, N., MacKenzie, R.E., Vrielink, A. Acta Crystallogr. D Biol. Crystallogr. (1999) [Pubmed]
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