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Gene Review

NOC2L  -  nucleolar complex associated 2 homolog (S....

Homo sapiens

Synonyms: DKFZP564C186, NET15, NET7, NIR, NOC2-like protein, ...
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Disease relevance of NOC2L

  • Near-IR (NIR) excitation at liquid He temperatures of photosystem II (PSII) membranes from the cyanobacterium Synechococcus vulcanus or from spinach poised in the S2 state results in the production of a g = 2.035 EPR resonance, reminiscent of metalloradical signals [1].
  • Wavelengths longer than the NIR wavelengths, although they could conceivably account for the occurrence of melanoma under clothed parts of the body, carry so little energy that they are probably unimportant [2].
  • Successful stent delivery was achieved in 100% versus 98.8%, respectively, with a slightly lower postprocedural diameter stenosis (7% vs. 9%, p = 0.04) after NIR and PS stent placement, respectively [3].
  • The study was an "equivalency" trial, designed to demonstrate that the NIR stent was not inferior to (i.e., equivalent or better than) the PS stent, for the primary end point of target vessel failure (defined as death, myocardial infarction, or target vessel revascularization) by 9 months [3].
  • Immediate and midterm results of 61 NIR stent placement attempts in 55 native coronary vessels in 52 patients demonstrate a high clinical success rate of 98%, no early stent thrombosis, and a 5-month angiographic restenosis rate of 23% [4].

High impact information on NOC2L

  • The IR patients differed from the NIR patients with respect to higher frequency of ICAs (P less than .001), thyroid antibodies (P less than .02), and the HLA antigen DR4 (P less than .02) [5].
  • The latter, most importantly, represents the first (dyad) member of a series of p-doped tetrathiafulvalene (stacked) arrays, and the thorough scrutiny of its electronic structure with the aid of Mulliken-Hush (two-state) analysis of the diagnostic (intervalence) NIR band reveals Robin-Day Class II behavior [6].
  • The combination of cyclic voltammetry, dynamic ESR line broadening, and electronic (NIR) spectroscopy allows the intervalence electron transfer between the redox centers in the mixed-valence system D-br-D*(+) [where br can be an aliphatic trimethylene or an aromatic (poly)phenylene bridge] to be probed quantitatively [7].
  • METHODS: One hundred and twenty patients with lesions in small coronary arteries (de novo, non-ostial lesion and reference diameter <3 mm) were randomly assigned to either balloon angioplasty or elective stent placement (7-cell NIR stent) [8].
  • NIR lanthanide luminescence by energy transfer from appended terpyridine-boradiazaindacene dyes [9].

Chemical compound and disease context of NOC2L

  • In conclusion, when compared with implantation of an uncoated premounted NIR stent, implantation of a heparin-coated premounted Jostent does not provide any more benefit with respect to initial efficacy, sub(acute) thrombosis and 6-month restenosis rates and 12-month clinical outcomes [10].

Biological context of NOC2L

  • Two important sequence elements, designated insulin enhancer binding site 1 (IEB1) or NIR and IEB2 or FAR, are involved in regulating expression of the rat insulin I gene [11].
  • The identification is based on the comparison of the NIR spectrum of a sample with typical spectra of the authentic drug using multivariate modelling and classification algorithms (PCA/SIMCA) [12].
  • Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes [13].
  • We discuss various methodological aspects and state of the art of fiber optic NIR RS in clinical and experimental dermatology to outline its present advantages and disadvantages for measuring skin in vivo, particularly its water content [14].
  • Sterile probes for emitting and detecting NIR light at a fixed separation of 40 mm were placed in turn on intact skin, skull, dura and cerebral cortex of 10 patients undergoing elective neurosurgery [15].

Anatomical context of NOC2L

  • A comparative evaluation of the effects of four sterilization methods on dentin disks was based on FTIR and ultraviolet-visible-near infrared (UV/VIS/NIR) spectra before and after sterilization by (1) gamma irradiation; (2) ethylene oxide; (3) dry heat; and (4) autoclaving [16].
  • NIR spectra of 118 sections from 36 human aortas were measured at 1000-2500 nm [17].
  • CONCLUSION: The findings indicate that simple assumptions regarding the distribution of the internal carotid artery blood supply to cerebral and extracerebral tissues, the photon path length through those tissues, and their relative contributions to attenuation of NIR light may not be justified [18].
  • Development of a fiber optic probe to measure NIR Raman spectra of cervical tissue in vivo [19].
  • Potentially, NIR offers the prospect of real-time control of the physiology of cultured cells in fermenters, leading to marked improvements in authenticity, purity and production efficiency [20].

Associations of NOC2L with chemical compounds

  • Specifically, the Au-imidazole assemblies formed at lower imidazole concentrations had the lowest fractal dimension (D(f) = 1.2) and the largest Raman enhancement factors for the dominant NIR-SERS feature, a ring-breathing vibrational mode at 954 cm(-1) [21].
  • The self-assembled Au-imidazole complexes were generated by the adsorption of imidazole molecules onto Au nanoparticles (NP) and were then characterized as aqueous suspensions by using NIR-SERS, angle-dependent light scattering with fractal dimension analysis, and visible extinction spectroscopy [21].
  • The NIR-induced increase in the oxidative capability of the Mn cluster is discussed in relation to the photochemical properties of a Mn(III) ion that exists in both S2 and S3 states [1].
  • Routine NIR analysis of caffeine in tablet form was found to be more flexible and much faster than that performed with the HPLC method [22].
  • The formation of the silica network and the titanium insertion were followed by a combination of diffuse reflectance UV/ Vis/NIR and FTIR spectroscopy [23].

Analytical, diagnostic and therapeutic context of NOC2L

  • METHODS and RESULTS: We deployed 3.0- and 4.0-mm Palmaz-Schatz, Wiktor, Multilink, NIR, and InStent stents in precision-cast phantoms [24].
  • Additional evidence for the strong electronic coupling is provided by UV-vis, NIR, and EPR spectroscopies and DFT calculations [25].
  • Quantitative near-IR (NIR) spectroscopic studies of these SWNT graft copolymers indicate a water solubility of about 5 mg/mL, and atomic force microscopy studies show a fairly uniform length and diameter [26].
  • A randomized comparison of the value of additional stenting after optimal balloon angioplasty for long coronary lesions: final results of the additional value of NIR stents for treatment of long coronary lesions (ADVANCE) study [27].
  • A similar increase was found from pulse radiolysis experiments on the wt NIR and three variants (Met150Gly, Met150His, and Met150Thr) [28].


  1. Near-IR irradiation of the S2 state of the water oxidizing complex of photosystem II at liquid helium temperatures produces the metalloradical intermediate attributed to S1Y(Z*). Koulougliotis, D., Shen, J.R., Ioannidis, N., Petrouleas, V. Biochemistry (2003) [Pubmed]
  2. Solar considerations in the development of cutaneous melanoma. Loggie, B.W., Eddy, J.A. Semin. Oncol. (1988) [Pubmed]
  3. Final results of a randomized trial comparing the NIR stent to the Palmaz-Schatz stent for narrowings in native coronary arteries. Baim, D.S., Cutlip, D.E., O'Shaughnessy, C.D., Hermiller, J.B., Kereiakes, D.J., Giambartolomei, A., Katz, S., Lansky, A.J., Fitzpatrick, M., Popma, J.J., Ho, K.K., Leon, M.B., Kuntz, R.E. Am. J. Cardiol. (2001) [Pubmed]
  4. Early experience with the NIR intracoronary stent. Lau, K.W., He, Q., Ding, Z.P., Quek, S., Johan, A. Am. J. Cardiol. (1998) [Pubmed]
  5. Organ-specific autoimmunity and HLA-DR antigens as markers for beta-cell destruction in patients with type II diabetes. Groop, L., Miettinen, A., Groop, P.H., Meri, S., Koskimies, S., Bottazzo, G.F. Diabetes (1988) [Pubmed]
  6. Molecular and electronic structures of the long-bonded pi-dimers of tetrathiafulvalene cation-radical in intermolecular electron transfer and in (solid-state) conductivity. Rosokha, S.V., Kochi, J.K. J. Am. Chem. Soc. (2007) [Pubmed]
  7. X-ray structure analysis and the intervalent electron transfer in organic mixed-valence crystals with bridged aromatic cation radicals. Lindeman, S.V., Rosokha, S.V., Sun, D., Kochi, J.K. J. Am. Chem. Soc. (2002) [Pubmed]
  8. Randomized comparison of coronary stenting with optimal balloon angioplasty for treatment of lesions in small coronary arteries. Park, S.W., Lee, C.W., Hong, M.K., Kim, J.J., Cho, G.Y., Nah, D.Y., Park, S.J. Eur. Heart J. (2000) [Pubmed]
  9. NIR lanthanide luminescence by energy transfer from appended terpyridine-boradiazaindacene dyes. Ziessel, R.F., Ulrich, G., Charbonnière, L., Imbert, D., Scopelliti, R., Bünzli, J.C. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
  10. Comparison of initial efficacy and long-term follow-up of heparin-coated Jostent with conventional NIR stent. Semiz, E., Ermiş, C., Yalçinkaya, S., Sancaktar, O., Değer, N. Japanese heart journal. (2003) [Pubmed]
  11. The helix-loop-helix transcription factor USF (upstream stimulating factor) binds to a regulatory sequence of the human insulin gene enhancer. Read, M.L., Clark, A.R., Docherty, K. Biochem. J. (1993) [Pubmed]
  12. Identification of counterfeit drugs using near-infrared spectroscopy. Scafi, S.H., Pasquini, C. The Analyst. (2001) [Pubmed]
  13. Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. Pogue, B.W., Jiang, S., Dehghani, H., Kogel, C., Soho, S., Srinivasan, S., Song, X., Tosteson, T.D., Poplack, S.P., Paulsen, K.D. Journal of biomedical optics. (2004) [Pubmed]
  14. Fiber optic near-infrared Raman spectroscopy for clinical noninvasive determination of water content in diseased skin and assessment of cutaneous edema. Eikje, N.S., Ozaki, Y., Aizawa, K., Arase, S. Journal of biomedical optics. (2005) [Pubmed]
  15. Behaviour of near-infrared light in the adult human head: implications for clinical near-infrared spectroscopy. Young, A.E., Germon, T.J., Barnett, N.J., Manara, A.R., Nelson, R.J. British journal of anaesthesia. (2000) [Pubmed]
  16. Sterilization of teeth by gamma radiation. White, J.M., Goodis, H.E., Marshall, S.J., Marshall, G.W. J. Dent. Res. (1994) [Pubmed]
  17. Determination of the cholesterol-collagen ratio of arterial atherosclerotic plaques using near infrared spectroscopy as a possible measure of plaque stability. Neumeister, V., Scheibe, M., Lattke, P., Jaross, W. Atherosclerosis (2002) [Pubmed]
  18. Changes in tissue oxyhaemoglobin concentration measured using multichannel near infrared spectroscopy during internal carotid angiography. Germon, T.J., Evans, P.E., Barnett, N.J., Lewis, T.T., Wall, P., Nelson, R.J. J. Neurol. Neurosurg. Psychiatr. (1997) [Pubmed]
  19. Development of a fiber optic probe to measure NIR Raman spectra of cervical tissue in vivo. Mahadevan-Jansen, A., Mitchell, M.F., Ramanujam, N., Utzinger, U., Richards-Kortum, R. Photochem. Photobiol. (1998) [Pubmed]
  20. Near infrared spectroscopy for bioprocess monitoring and control: current status and future trends. Scarff, M., Arnold, S.A., Harvey, L.M., McNeil, B. Crit. Rev. Biotechnol. (2006) [Pubmed]
  21. In vivo detection of gold-imidazole self-assembly complexes: NIR-SERS signal reporters. Souza, G.R., Levin, C.S., Hajitou, A., Pasqualini, R., Arap, W., Miller, J.H. Anal. Chem. (2006) [Pubmed]
  22. Development and validation of a near-infrared method for the quantitation of caffeine in intact single tablets. Laasonen, M., Harmia-Pulkkinen, T., Simard, C., Räsänen, M., Vuorela, H. Anal. Chem. (2003) [Pubmed]
  23. One-step synthesis of a highly active, mesoporous, titanium-containing silica by using bifunctional templating. Shan, Z., Gianotti, E., Jansen, J.C., Peters, J.A., Marchese, L., Maschmeyer, T. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
  24. Coronary stents: In vitro aspects of an angiographic and ultrasound quantification with in vivo correlation. Pomerantsev, E.V., Kobayashi, Y., Fitzgerald, P.J., Grube, E., Sanders, W.J., Alderman, E.L., Oesterle, S.N., Yock, P.G., Stertzer, S.H. Circulation (1998) [Pubmed]
  25. Uniquely strong electronic communication between [Mo2] units linked by dioxolene dianions. Cotton, F.A., Murillo, C.A., Villagrán, D., Yu, R. J. Am. Chem. Soc. (2006) [Pubmed]
  26. Synthesis and characterization of water soluble single-walled carbon nanotube graft copolymers. Zhao, B., Hu, H., Yu, A., Perea, D., Haddon, R.C. J. Am. Chem. Soc. (2005) [Pubmed]
  27. A randomized comparison of the value of additional stenting after optimal balloon angioplasty for long coronary lesions: final results of the additional value of NIR stents for treatment of long coronary lesions (ADVANCE) study. Serruys, P.W., Foley, D.P., Suttorp, M.J., Rensing, B.J., Suryapranata, H., Materne, P., van den Bos, A., Benit, E., Anzuini, A., Rutsch, W., Legrand, V., Dawkins, K., Cobaugh, M., Bressers, M., Backx, B., Wijns, W., Colombo, A. J. Am. Coll. Cardiol. (2002) [Pubmed]
  28. Effect of the methionine ligand on the reorganization energy of the type-1 copper site of nitrite reductase. Wijma, H.J., MacPherson, I., Farver, O., Tocheva, E.I., Pecht, I., Verbeet, M.P., Murphy, M.E., Canters, G.W. J. Am. Chem. Soc. (2007) [Pubmed]
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