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MeSH Review

Fiber Optics

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Disease relevance of Fiber Optics

  • In this study, a fiber-optic DNA microarray using microsphere-immobilized oligonucleotide probes specific for the Salmonella invA and spvB genes was developed for detection of Salmonella spp [1].
  • Grain counts of retinal autoradiograms obtained from animals of all ages employed in this study demonstrated that [3H] proline is rapidly incorporated by all retinal neurons but becomes increasingly concentrated within the inner nuclear, ganglion cell and optic fiber layers between 2h and 2 days after injection [2].
  • In the second approach, microbial activity was monitored using multiple fiber optics emplaced in the porous medium to detect luminescence produced by Pseudomonas putida RB1353, a bioluminescent reporter organism that produces light when salicylate (an intermediate of naphthalene degradation) is present [3].
  • The animals were ventilated with air while either 10% CO2 or air (hypocapnia) was infused through a segment obstructed with a fiber-optic bronchoscope [4].
  • METHODS: Full-term, healthy infants with nonhemolytic hyperbilirubinemia (bilirubin concentration, >255 micromol/L or 222 micromol/L at <48 hours of age) were allocated randomly to one of four modes of phototherapy: standard fiber-optic mat (Ohmeda Biliblanket), a large version, double standard Biliblankets, and conventional phototherapy [5].

High impact information on Fiber Optics

  • In addition, by examining axonal behavior in the retinas with overexpression of Irx4 and using several in vivo assays to test the effect of Slit1, we found that Slit1 acts positively to guide the retinal axons inside the optic fiber layer (OFL) [6].
  • METHODS: Fifty-five patients with proven EHPVO underwent repeated injection sclerotherapy via either a modified rigid esophagoscope under general anaesthesia or a fiber-optic endoscope under light sedation, using ethanolamine oleate as the sclerosant [7].
  • In summary, the data suggest a possible role of chick Sema3E/collapsin-5 in restricting growth of retinal ganglion cell axons to the optic fiber layer [8].
  • Three of the biotin esters (biotin-N-hydroxysuccinimidester, biotin-epsilon-aminocaproic acid-N-hydroxysuccinimidester, and desthiobiotin-N-hydroxysuccinimidester) prominently marked the optic fiber layer in the retina and the biotin labels were transported along the optic pathway [9].
  • This fiber-optic electroconductive surface modification is done by the deposition of a thin layer of indium tin oxide on the silica surface of the fiber optics [10].

Chemical compound and disease context of Fiber Optics


Biological context of Fiber Optics


Anatomical context of Fiber Optics

  • In the superior colliculus, pre-ensheathing oligodendrocytes are present in the optic fiber layer (SO) on P7, but not in the superficial gray layer (SGS) until P11 [15].
  • METHODS: The authors measured chronotropic responses of cultured rat ventricular myocytes induced by propofol stimulation with a sensor, a fiber-optic displacement measurement instrument [16].
  • In sections of retinal tissue from animals 7 days after hatching (Rp7), in addition to the inner and outer segments of the photoreceptor layer, the plexiform and optic fiber layers were stained with rhodamine-labeled PNA, indicating that, besides photoreceptor cells, other cellular types contribute to the PNA staining [17].
  • This early appearance before synaptic differentiation, together with the transient expression of synaptotagmin immunoreactivity in the synapse-free optic fiber layer, suggests that in the developing central nervous system (CNS) these proteins are not confined to synapses [18].
  • When the retinal axons navigated in the chiasm at E13-E14, immunoreactive CS remained at a low level in the optic fiber layer of the chiasm but was observed prominently in the caudal parts of the ventral diencephalon [19].

Associations of Fiber Optics with chemical compounds


Gene context of Fiber Optics

  • At later developmental stages (E16 to postnatal day 0), FGFR were found in the optic fiber layer and the inner plexiform layer [25].
  • Fiber optic immunosensors for cardiovascular disease diagnosis: quantification of Protein C, Factor V Leiden, and cardiac Troponin T in plasma [26].
  • An enzyme layer composed of glutamate dehydrogenase (GDH) and glutamate-pyruvate transaminase (GPT) is used to produce reduced nicotinamide adenine dinucleotide (NADH) at the tip of a fiber-optic probe [27].
  • The resulting product formed between DTNB and absorbed SO(2) is spectrophotometrically monitored at 410 nm with a charge coupled device (CCD) fiber optic spectrometer [28].
  • Sema3E/collapsin-5 receptor sites were visualized by alkaline phosphatase fusion proteins in the axon-rich optic fiber layer [8].

Analytical, diagnostic and therapeutic context of Fiber Optics


  1. Detection of Salmonella spp. Using microsphere-based, fiber-optic DNA microarrays. Ahn, S., Walt, D.R. Anal. Chem. (2005) [Pubmed]
  2. Inhibition of axoplasmic transport in the developing visual system of the rat-II, Quantitative analysis of alterations in transport of tritiated proline or fucose. Matthews, M.A., West, L.C., Clarkson, D.B. Neuroscience (1982) [Pubmed]
  3. The influence of substrate and electron acceptor availability on bioactive zone dynamics in porous media. Yolcubal, I., Dorn, J.G., Maier, R.M., Brusseau, M.L. J. Contam. Hydrol. (2003) [Pubmed]
  4. Effects of methacholine and hypocapnia on airways and collateral ventilation in dogs. Smith, L.J., Inners, C.R., Terry, P.B., Menkes, H.A., Traystman, R.J. Journal of applied physiology: respiratory, environmental and exercise physiology. (1979) [Pubmed]
  5. Efficacy of bidirectional fiber-optic phototherapy for neonatal hyperbilirubinemia. Tan, K.L. Pediatrics (1997) [Pubmed]
  6. Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Jin, Z., Zhang, J., Klar, A., Chédotal, A., Rao, Y., Cepko, C.L., Bao, Z.Z. Development (2003) [Pubmed]
  7. A 15-year experience of injection sclerotherapy in adult patients with extrahepatic portal venous obstruction. Kahn, D., Krige, J.E., Terblanche, J., Bornman, P.C., Robson, S.C. Ann. Surg. (1994) [Pubmed]
  8. Semaphorin 3E/collapsin-5 inhibits growing retinal axons. Steinbach, K., Volkmer, H., Schlosshauer, B. Exp. Cell Res. (2002) [Pubmed]
  9. Anterograde tracing of retinal axons in the avian embryo with low molecular weight derivatives of biotin. Halfter, W. Dev. Biol. (1987) [Pubmed]
  10. Optical fiber immunosensor based on a poly(pyrrole-benzophenone) film for the detection of antibodies to viral antigen. Konry, T., Novoa, A., Shemer-Avni, Y., Hanuka, N., Cosnier, S., Lepellec, A., Marks, R.S. Anal. Chem. (2005) [Pubmed]
  11. Trimethyltin induced pathology in sensory neurons. Chang, L.W., Dyer, R.S. Neurobehavioral toxicology and teratology. (1983) [Pubmed]
  12. Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo. Kostourou, V., Troy, H., Murray, J.F., Cullis, E.R., Whitley, G.S., Griffiths, J.R., Robinson, S.P. Neoplasia (2004) [Pubmed]
  13. Application of a novel fiber-optic biosensor in situ to investigate the metabolic effect of lactate infusion. Dager, S.R., Yim, J.B., Khalil, G.E., Artru, A.A., Bowden, D.M., Kenny, M.A. Neuropsychopharmacology (1995) [Pubmed]
  14. Monitoring of itaconic acid hydrogenation in a trickle bed reactor using fiber-optic coupled near-infrared spectroscopy. Wood, J., Turner, P.H. Applied spectroscopy. (2003) [Pubmed]
  15. Oligodendrocytes and myelin formation along the optic tract of the developing hamster: an immunohistochemical study using the Rip antibody. Jhaveri, S., Erzurumlu, R.S., Friedman, B., Schneider, G.E. Glia (1992) [Pubmed]
  16. Propofol-induced depression of cultured rat ventricular myocytes is related to the M2-acetylcholine receptor-NO-cGMP signaling pathway. Yamamoto, S., Kawana, S., Miyamoto, A., Ohshika, H., Namiki, A. Anesthesiology (1999) [Pubmed]
  17. Peanut agglutinin binding glycoproteins in the chick retina: their presence in Müller glia cells. Arregui, C., Barra, H.S., Landa, C.A. J. Neurosci. Res. (1992) [Pubmed]
  18. Formation of synaptic specializations in the inner plexiform layer of the developing chick retina. Hering, H., Kröger, S. J. Comp. Neurol. (1996) [Pubmed]
  19. Expression of chondroitin sulfate proteoglycans in the chiasm of mouse embryos. Chung, K.Y., Shum, D.K., Chan, S.O. J. Comp. Neurol. (2000) [Pubmed]
  20. Dual-analyte fiber-optic sensor for the simultaneous and continuous measurement of glucose and oxygen. Li, L., Walt, D.R. Anal. Chem. (1995) [Pubmed]
  21. Measurement of free phenytoin in blood with a self-contained fiber-optic immunosensor. Astles, J.R., Miller, W.G. Anal. Chem. (1994) [Pubmed]
  22. Development of an "electroptode" immunosensor: indium tin oxide-coated optical fiber tips conjugated with an electropolymerized thin film with conjugated cholera toxin B subunit. Konry, T., Novoa, A., Cosnier, S., Marks, R.S. Anal. Chem. (2003) [Pubmed]
  23. Single fiber-optic pH sensor based on changes in reflection accompanying polymer swelling. Shakhsher, Z., Seitz, W.R., Legg, K.D. Anal. Chem. (1994) [Pubmed]
  24. Fiber-optic ammonia sensor for measuring synaptic glutamate and extracellular ammonia. Kar, S., Arnold, M.A. Anal. Chem. (1992) [Pubmed]
  25. Changes in expression of fibroblast growth factor receptors during development of the mouse retinofugal pathway. Lin, L., Taylor, J.S., Chan, S.O. J. Comp. Neurol. (2002) [Pubmed]
  26. Fiber optic immunosensors for cardiovascular disease diagnosis: quantification of Protein C, Factor V Leiden, and cardiac Troponin T in plasma. Kwon, H.J., Peiper, S.C., Kang, K.A. Adv. Exp. Med. Biol. (2003) [Pubmed]
  27. Dual-enzyme fiber-optic biosensor for glutamate based on reduced nicotinamide adenine dinucleotide luminescence. Wang, A.J., Arnold, M.A. Anal. Chem. (1992) [Pubmed]
  28. Flow injection determination of gaseous sulfur dioxide with gas permeation denuder-based online sampling and preconcentration. Guo, Z.X., Li, Y.Z., Zhang, X.X., Chang, W.B., Ci, Y.X. Analytical and bioanalytical chemistry. (2002) [Pubmed]
  29. Oxygen optrode for use in a fiber-optic glucose biosensor. Moreno-Bondi, M.C., Wolfbeis, O.S., Leiner, M.J., Schaffar, B.P. Anal. Chem. (1990) [Pubmed]
  30. Pulmonary disposition of roxithromycin (RU 28965), a new macrolide antibiotic. Chastre, J., Brun, P., Fourtillan, J.B., Soler, P., Basset, G., Manuel, C., Trouillet, J.L., Gibert, C. Antimicrob. Agents Chemother. (1987) [Pubmed]
  31. Noninvasive method for monitoring ethanol in fermentation processes using fiber-optic near-infrared spectroscopy. Cavinato, A.G., Mayes, D.M., Ge, Z.H., Callis, J.B. Anal. Chem. (1990) [Pubmed]
  32. Injury and adhesion formation following ovarian wedge resection with different thermal surgical modalities. Bhatta, N., Isaacson, K., Flotte, T., Schiff, I., Anderson, R.R. Lasers in surgery and medicine. (1993) [Pubmed]
  33. Fiber optic monitoring of carbamate pesticides using porous glass with covalently bound chlorophenol red. Xavier, M.P., Vallejo, B., Marazuela, M.D., Moreno-Bondi, M.C., Baldini, F., Falai, A. Biosensors & bioelectronics. (2000) [Pubmed]
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