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Gene Review

Avpr1b  -  arginine vasopressin receptor 1B

Mus musculus

Synonyms: AVPR V1b, AVPR V3, AVPR3, Antidiuretic hormone receptor 1b, V1BR, ...
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Disease relevance of Avpr1b


Psychiatry related information on Avpr1b

  • Preliminary evidence suggests that female V1B receptor knockout mice could also have social memory deficits [4].
  • In this study, we characterized more thoroughly the social behavior of vasopressin 1b receptor null (V1bR-/-) mice [5].
  • This difference in behavior is not explained by an anosmic condition as there were no differences between V1bR-/- and V1bR+/+ mice in their abilities to detect a cookie buried in clean bedding, or in their ability to perform in an operant conditioning task using a fully automated liquid dilution olfactometer [5].
  • As such, antagonists of the CRF1 and V1b receptor subtypes are being developed as potential treatments for affective disorders [6].

High impact information on Avpr1b

  • AVP-induced ACTH release from primary cultured pituitary cells in V1bR-/- mice was also blunted [7].
  • Fos-mapping within chemosensory responsive regions suggests that the behavioral deficits in V1bR knockout mice are not due to defects in detection and transmission of chemosensory signals to the brain [3].
  • A radioligand binding study showed that SR49059 and OPC-21268 potently inhibited [3H]AVP binding to the cloned mouse V1a receptor, with Ki values of 27 and 510 nM, respectively, whereas SSR149415 potently inhibited [3H]AVP binding to the cloned mouse V1b receptor with a Ki value of 110 nM [8].
  • Moreover, PPI deficits observed in the V1bR KO mice are significantly reversed by atypical antipsychotics such as risperidone and clozapine but not by a typical neuroleptic haloperidol, like in schizophrenic patients [9].
  • V1bR KO mice also showed a decrease in basal levels of extracellular dopamine (DA) in the medial prefrontal cortex, which is thought to be an important brain region for PPI [9].

Biological context of Avpr1b


Associations of Avpr1b with chemical compounds

  • To investigate the role of Avp in the hypothalamic-pituitary-adrenal axis response to stress, we measured plasma ACTH and corticosterone (CORT) levels in Avpr1b knockout (KO) mice and wild-type controls in response to two acute (restraint and insulin administration) and one form of chronic (daily restraint for 14 d) stress [1].
  • Among these three subtypes, the vasopressin V1b receptor is specifically expressed in pituitary corticotrophs and mediates the stimulatory effect of vasopressin on ACTH release [7].
  • In order to confirm the identity of the sequence, the V3/V1b receptor cDNA was cloned and stably expressed in CHO-AA8 Tet-Off cells under the control of tetracycline [11].
  • These effects were similar to those obtained with the V1b receptor antagonist SSR149415 (3-10 mg/kg, p.o.), diazepam (1 mg/kg, p.o.) and buspirone (10 mg/kg, p.o.). Fluoxetine and SSR240600 were devoid of effects in this test [12].
  • In V1bR-/- mice, OT-induced ACTH release was significantly inhibited by CL-14-26 at 10(-8) m and completely inhibited at 10(-7)m. These results indicate that OT induces the ACTH response via OT and V1b receptors inV1bR+/+ mice but via only OT receptors in V1bR-/- mice [13].

Other interactions of Avpr1b

  • Acute restraint (30 min) increased plasma ACTH and CORT to a similar level in both the Avpr1b mutant and wild-type mice [1].
  • The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain [14].
  • From all OT and VP receptors, only OTR was expressed by all T-cell subsets, while V1bR was found in double positive and single positive CD8 cells [10].

Analytical, diagnostic and therapeutic context of Avpr1b


  1. The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors. Lolait, S.J., Stewart, L.Q., Jessop, D.S., Young, W.S., O'Carroll, A.M. Endocrinology (2007) [Pubmed]
  2. The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors. Caldwell, H.K., Stewart, J., Wiedholz, L.M., Millstein, R.A., Iacangelo, A., Holmes, A., Young, W.S., Wersinger, S.R. Neuropeptides (2006) [Pubmed]
  3. Vasopressin V1b receptor knockout reduces aggressive behavior in male mice. Wersinger, S.R., Ginns, E.I., O'Carroll, A.M., Lolait, S.J., Young, W.S. Mol. Psychiatry (2002) [Pubmed]
  4. Neuroendocrine basis of social recognition. Winslow, J.T., Insel, T.R. Curr. Opin. Neurobiol. (2004) [Pubmed]
  5. Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Wersinger, S.R., Kelliher, K.R., Zufall, F., Lolait, S.J., O'Carroll, A.M., Young, W.S. Hormones and behavior. (2004) [Pubmed]
  6. Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Hodgson, R.A., Higgins, G.A., Guthrie, D.H., Lu, S.X., Pond, A.J., Mullins, D.E., Guzzi, M.F., Parker, E.M., Varty, G.B. Pharmacol. Biochem. Behav. (2007) [Pubmed]
  7. The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions. Tanoue, A., Ito, S., Honda, K., Oshikawa, S., Kitagawa, Y., Koshimizu, T.A., Mori, T., Tsujimoto, G. J. Clin. Invest. (2004) [Pubmed]
  8. Vasopressin stimulates insulin release from islet cells through V1b receptors: a combined pharmacological/knockout approach. Oshikawa, S., Tanoue, A., Koshimizu, T.A., Kitagawa, Y., Tsujimoto, G. Mol. Pharmacol. (2004) [Pubmed]
  9. Disruption of the prepulse inhibition of the startle reflex in vasopressin V1b receptor knockout mice: reversal by antipsychotic drugs. Egashira, N., Tanoue, A., Higashihara, F., Fuchigami, H., Sano, K., Mishima, K., Fukue, Y., Nagai, H., Takano, Y., Tsujimoto, G., Stemmelin, J., Griebel, G., Iwasaki, K., Ikeda, T., Nishimura, R., Fujiwara, M. Neuropsychopharmacology (2005) [Pubmed]
  10. Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network. Hansenne, I., Rasier, G., Péqueux, C., Brilot, F., Renard, C.h., Breton, C., Greimers, R., Legros, J.J., Geenen, V., Martens, H.J. J. Neuroimmunol. (2005) [Pubmed]
  11. Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor. Ventura, M.A., René, P., de Keyzer, Y., Bertagna, X., Clauser, E. J. Mol. Endocrinol. (1999) [Pubmed]
  12. Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils. Salomé, N., Stemmelin, J., Cohen, C., Griebel, G. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  13. Effects of vasopressin V1b receptor deficiency on adrenocorticotropin release from anterior pituitary cells in response to oxytocin stimulation. Nakamura, K., Fujiwara, Y., Mizutani, R., Sanbe, A., Miyauchi, N., Hiroyama, M., Yamauchi, J., Yamashita, T., Nakamura, S., Mori, T., Tsujimoto, G., Tanoue, A. Endocrinology (2008) [Pubmed]
  14. The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy. Young, W.S., Li, J., Wersinger, S.R., Palkovits, M. Neuroscience (2006) [Pubmed]
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