The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Avpr1b  -  arginine vasopressin receptor 1B

Rattus norvegicus

Synonyms: AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, V1bR, Vasopressin V1b receptor, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Avpr1b

  • The rat V1b receptor is a protein of 421 amino acids that has 37-50% identity with the V1a and V2 receptors [1].
  • We have isolated a clone encoding the V1b receptor from a rat pituitary cDNA library using polymerase chain reaction (PCR)-based methodology [1].
  • Electrophoretic mobility shift assay showed specific binding of pituitary nuclear extracts to radiolabeled GAGA oligonucleotides, which increased following restraint stress in rats, a condition associated with V1bR up-regulation [2].
  • Transfection of a 2.5-kb V1bR fragment (2161 bp upstream and 377 bp downstream of the proximal transcriptional start point) into a luciferase vector (V1bRp2.5-Luc) results in promoter activity in these cells [2].
  • Posttranscriptional mechanisms play an important role regulating pituitary levels of vasopressin V1b receptors (V1bR) during adaptation to stress [3].
 

Biological context of Avpr1b

  • Transfection of bicistronic luciferase constructs into MCF-7 cells showed marked increases in translation of the second cistron after insertion of a 499-bp fragment of the V1bR 5'UTR in the intercistronic region, independently of cap-mediated translation, indicating the presence of IRES activity [3].
  • The data show that regulation of IRES activity in the 5'UTR of the V1bR mRNA probably through phosphorylation of eIF4G may serve as a mechanism for rapid changes in V1bR translation to meet physiological demands [3].
  • The V1B receptor agonist [deamino-Cys1,beta-(3-pyridyl)-D-Ala2,Arg8]vasopressin (100-1000 nM) and the V2 receptor agonist [deamino-Cys1,D-Arg8]vasopressin (1-10 nM) were devoid of any pressor activity and did not potentiate methoxamine-evoked vasoconstriction [4].
  • The results provide evidence for differential regulation of V1a and V1b receptors genes in the brain stem of TGR rats that is manifested by downregulation of V1aR mRNA in the medulla and upregulation of V1bR mRNA in the mesencephalopontine region [5].
  • Stimulation of IRES activity through protein kinase C-mediated pathways results in V1bR mRNA translation increasing V1bR protein levels [6].
 

Anatomical context of Avpr1b

 

Associations of Avpr1b with chemical compounds

  • This vasopressin receptor is distinct from both the V1a receptor and the V2 receptor and may be either the V1b receptor or a novel vasopressin receptor subtype [9].
  • Furthermore the analogues of dPTyr(Me)AVP may be useful in studies on the role(s) of AVP in the V1b-receptor-mediated release of ACTH from corticotrophs [10].
  • Dexamethasone injection for 7 days decreased VP binding but increased V1b-R mRNA, indicating that mRNA levels do not reflect receptor number [11].
  • In spite of the decrease in V1b receptor mRNA following i.p. hypertonic saline injection, VP binding in pituitary membrane rich fractions, and VP-stimulated inositol phosphate formation in quartered hemipituitaries were increased by 24 and 39%, respectively [12].
 

Other interactions of Avpr1b

 

Analytical, diagnostic and therapeutic context of Avpr1b

  • However, transcripts of the V1b VP receptor (V1bR) have been detected throughout the rat brain by RT-PCR and in situ hybridization, indicating that the V1bR adds to the population of central VP receptors [8].
  • Immunohistochemistry revealed the presence of the V1bR in pituitary corticotrophs as expected [8].
  • In addition, the data suggest that the down-regulation of VP binding after long-term adrenalectomy is due to posttranscriptional events rather than to changes in V1b-R mRNA [18].
  • In response to acute stress, V1b receptor mRNA increased by 77 +/- 5% (3.7 Kb band) after 4 h immobilization for 1 h, whereas both bands were reduced by 49 +/- 5% and 45 +/- 5%, 4 h after a single i.p. hypertonic saline injection [12].
  • The present study sought to provide confirmatory evidence for the antidepressant-like effects of the selective vasopressin V1b receptor antagonist SSR149415, which had been previously demonstrated in a variety of animal models [17].

References

  1. Extrapituitary expression of the rat V1b vasopressin receptor gene. Lolait, S.J., O'Carroll, A.M., Mahan, L.C., Felder, C.C., Button, D.C., Young, W.S., Mezey, E., Brownstein, M.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Transcriptional regulation of the pituitary vasopressin V1b receptor involves a GAGA-binding protein. Volpi, S., Rabadan-Diehl, C., Cawley, N., Aguilera, G. J. Biol. Chem. (2002) [Pubmed]
  3. Translational regulation of the vasopressin v1b receptor involves an internal ribosome entry site. Rabadan-Diehl, C., Volpi, S., Nikodemova, M., Aguilera, G. Mol. Endocrinol. (2003) [Pubmed]
  4. Lack of effect of a selective vasopressin V1A receptor antagonist SR 49,059, on potentiation by vasopressin of adrenoceptor-mediated pressor responses in the rat mesenteric arterial bed. Heinemann, A., Horina, G., Stauber, R.E., Pertl, C., Holzer, P., Peskar, B.A. Br. J. Pharmacol. (1998) [Pubmed]
  5. Differential expression of vasopressin V1a and V1b receptors mRNA in the brain of renin transgenic TGR(mRen2)27 and Sprague-Dawley rats. Góźdź, A., Szczepańska-Sadowska, E., Maśliński, W., Kumosa, M., Szczepańska, K., Dobruch, J. Brain Res. Bull. (2003) [Pubmed]
  6. Transcriptional and post-transcriptional mechanisms regulating the rat pituitary vasopressin V1b receptor gene. Aguilera, G., Volpi, S., Rabadan-Diehl, C. J. Mol. Endocrinol. (2003) [Pubmed]
  7. Comparative distribution of vasopressin V1b and oxytocin receptor messenger ribonucleic acids in brain. Vaccari, C., Lolait, S.J., Ostrowski, N.L. Endocrinology (1998) [Pubmed]
  8. Immunohistochemical localization of the vasopressin V1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin. Hernando, F., Schoots, O., Lolait, S.J., Burbach, J.P. Endocrinology (2001) [Pubmed]
  9. Vasopressin and oxytocin receptors coupled to Ca2+ mobilization in rat inner medullary collecting duct. Maeda, Y., Han, J.S., Gibson, C.C., Knepper, M.A. Am. J. Physiol. (1993) [Pubmed]
  10. Synthesis and some pharmacological properties of potent and selective antagonists of the vasopressor (V1-receptor) response to arginine-vasopressin. Manning, M., Stoev, S., Bankowski, K., Misicka, A., Lammek, B., Wo, N.C., Sawyer, W.H. J. Med. Chem. (1992) [Pubmed]
  11. Glucocorticoids increase vasopressin V1b receptor coupling to phospholipase C. Rabadan-Diehl, C., Aguilera, G. Endocrinology (1998) [Pubmed]
  12. Regulation of pituitary vasopressin V1b receptor mRNA during stress in the rat. Rabadan-Diehl, C., Lolait, S.J., Aguilera, G. J. Neuroendocrinol. (1995) [Pubmed]
  13. In vivo and in vitro effects of arginine-vasopressin receptor antagonists on the hypothalamic-pituitary-adrenal axis in the rat. Bernardini, R., Chiarenza, A., Kamilaris, T.C., Renaud, N., Lempereur, L., Demitrack, M., Gold, P.W., Chrousos, G.P. Neuroendocrinology (1994) [Pubmed]
  14. Oxytocin-stimulated release of adrenocorticotropin from the rat pituitary is mediated by arginine vasopressin receptors of the V1b type. Schlosser, S.F., Almeida, O.F., Patchev, V.K., Yassouridis, A., Elands, J. Endocrinology (1994) [Pubmed]
  15. Reduced hypothalamic vasopressin secretion underlies attenuated adrenocorticotropin stress responses in pregnant rats. Ma, S., Shipston, M.J., Morilak, D., Russell, J.A. Endocrinology (2005) [Pubmed]
  16. Molecular and functional characterization of V1b vasopressin receptor in rat adrenal medulla. Grazzini, E., Lodboerer, A.M., Perez-Martin, A., Joubert, D., Guillon, G. Endocrinology (1996) [Pubmed]
  17. Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat. Overstreet, D.H., Griebel, G. Pharmacol. Biochem. Behav. (2005) [Pubmed]
  18. Regulation of pituitary V1b vasopressin receptor messenger ribonucleic acid by adrenalectomy and glucocorticoid administration. Rabadan-Diehl, C., Makara, G., Kiss, A., Lolait, S., Zelena, D., Ochedalski, T., Aguilera, G. Endocrinology (1997) [Pubmed]
 
WikiGenes - Universities