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Gene Review

LY75  -  lymphocyte antigen 75

Homo sapiens

Synonyms: C-type lectin domain family 13 member B, CD205, CLEC13B, DEC-205, GP200-MR6, ...
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Disease relevance of LY75

  • Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1 [1].
  • These results suggest that analysis of gp200-MR6 expression may be useful in tumour grading and prognostic evaluation in breast cancer [2].
  • Furthermore, a preliminary study showed that benign epithelial hyperplasia of the breast expresses the gp200-MR6 heterogeneously [2].
  • Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124) [3].
  • In order to generate reagents that could be used in murine thymic functional studies we isolated antibodies specific to human gp200-MR6, using a phage display library expressing single-chain (sFv) antibodies [4].

High impact information on LY75

  • Immature (DEC205, CD1a) and activated/mature (CD83, CD40) dendritic cell transcripts were significantly elevated in ALS tissues [5].
  • Notably, qualitatively different immune responses were generated by targeting Ag to Dectin-1 vs CD205, a molecule expressed on CD8alpha+CD4-CD11b- DCs, dermal DCs, and Langerhans cells [6].
  • Those expressing CD8alpha together with CD205, found primarily in the T-cell areas of the spleen and lymph nodes, are the major subset responsible for cross-presenting cellular antigens [7].
  • The resulting reading frames encode the DEC-205 ectodomain plus the DCL-1 ectodomain, the transmembrane, and the cytoplasmic domain [1].
  • Using 3'-rapid amplification of cDNA ends (RACE) we identified an alternative mRNA for the DEC-205 multilectin receptor in the HRS cell line L428 [1].

Biological context of LY75


Anatomical context of LY75


Associations of LY75 with chemical compounds

  • Biochemical analysis and cDNA cloning reveal that gp200-MR6 belongs to the human macrophage mannose receptor family of multidomain molecules [8].
  • We also show that the gp200-MR6 molecule is closely associated with tyrosine kinase activity; the link between gp200-MR6 and the IL-4 receptor may therefore be via intracellular signaling pathways, with multifunctionality residing in its extracellular multidomain structure [8].
  • Monoclonal antibody (mAb) MR6 recognises a 200 kDa glycoprotein, gp200-MR6, which is expressed at high levels on the surface of human thymic cortical epithelium [12].

Regulatory relationships of LY75

  • In addition, CRP dramatically down-regulated expression of the antigen-uptake molecules CD205 and CD206, resulting in reduced DC endocytosis [13].

Other interactions of LY75

  • Monoclonal antibody MR6 detects gp200-MR6, a molecule functionally associated with the interleukin 4 (IL- 4) receptor [3].
  • In addition we demonstrate in both naive Lewis rats and C57BL/6 mice the presence of increased numbers of cells bearing DC markers (OX62 and MHCII, in rats, or CD11C, 33D1, MHCII, and F4/80, but not DEC205, in mice) in sites of brain delivery of RAdhsFlt3L [14].
  • Emphasis was laid on expression patterns of DEC-205/CD205 and BDCA-2, a marker for plasmacytoid dendritic cells [15].
  • In addition, 3 DC maturation markers not present on the microarrays (DEC205, DC LAMP and CCR7) were analyzed using real-time RT-PCR and found to be up-regulated at several time points [16].
  • This review discusses the structure and function of these four proteins-the mannose receptor (MR), the M-type receptor for secretory phospholipases A(2) (PLA(2)R), DEC-205/gp200-MR6 and Endo180/uPARAP [17].

Analytical, diagnostic and therapeutic context of LY75


  1. Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1. Kato, M., Khan, S., Gonzalez, N., O'Neill, B.P., McDonald, K.J., Cooper, B.J., Angel, N.Z., Hart, D.N. J. Biol. Chem. (2003) [Pubmed]
  2. Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast. al-Tubuly, A.A., Luqmani, Y.A., Shousha, S., Melcher, D., Ritter, M.A. Br. J. Cancer (1996) [Pubmed]
  3. Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124). Tungekar, M.F., Gatter, K.C., Ritter, M.A. Br. J. Cancer (1996) [Pubmed]
  4. Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development. Palmer, D.B., Crompton, T., Marandi, M.B., George, A.J., Ritter, M.A. Immunology (1999) [Pubmed]
  5. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Henkel, J.S., Engelhardt, J.I., Siklós, L., Simpson, E.P., Kim, S.H., Pan, T., Goodman, J.C., Siddique, T., Beers, D.R., Appel, S.H. Ann. Neurol. (2004) [Pubmed]
  6. Preferential induction of CD4+ T cell responses through in vivo targeting of antigen to dendritic cell-associated C-type lectin-1. Carter, R.W., Thompson, C., Reid, D.M., Wong, S.Y., Tough, D.F. J. Immunol. (2006) [Pubmed]
  7. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Heath, W.R., Belz, G.T., Behrens, G.M., Smith, C.M., Forehan, S.P., Parish, I.A., Davey, G.M., Wilson, N.S., Carbone, F.R., Villadangos, J.A. Immunol. Rev. (2004) [Pubmed]
  8. The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family. McKay, P.F., Imami, N., Johns, M., Taylor-Fishwick, D.A., Sedibane, L.M., Totty, N.F., Hsuan, J.J., Palmer, D.B., George, A.J., Foxwell, B.M., Ritter, M.A. Eur. J. Immunol. (1998) [Pubmed]
  9. Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. Kato, M., Neil, T.K., Fearnley, D.B., McLellan, A.D., Vuckovic, S., Hart, D.N. Int. Immunol. (2000) [Pubmed]
  10. cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells. Kato, M., Neil, T.K., Clark, G.J., Morris, C.M., Sorg, R.V., Hart, D.N. Immunogenetics (1998) [Pubmed]
  11. A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Guo, M., Gong, S., Maric, S., Misulovin, Z., Pack, M., Mahnke, K., Nussenzweig, M.C., Steinman, R.M. Hum. Immunol. (2000) [Pubmed]
  12. Antibodies to human thymic epithelium form part of the murine autoreactive repertoire. Freysdottir, J., Ritter, M.A. Dev. Immunol. (2001) [Pubmed]
  13. C-reactive protein impairs human CD14(+) monocyte-derived dendritic cell differentiation, maturation and function. Zhang, R., Becnel, L., Li, M., Chen, C., Yao, Q. Eur. J. Immunol. (2006) [Pubmed]
  14. Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression. Ali, S., Curtin, J.F., Zirger, J.M., Xiong, W., King, G.D., Barcia, C., Liu, C., Puntel, M., Goverdhana, S., Lowenstein, P.R., Castro, M.G. Mol. Ther. (2004) [Pubmed]
  15. Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Ebner, S., Ehammer, Z., Holzmann, S., Schwingshackl, P., Forstner, M., Stoitzner, P., Huemer, G.M., Fritsch, P., Romani, N. Int. Immunol. (2004) [Pubmed]
  16. Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Schoeters, E., Nuijten, J.M., Van Den Heuvel, R.L., Nelissen, I., Witters, H., Schoeters, G.E., Van Tendeloo, V.F., Berneman, Z.N., Verheyen, G.R. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  17. The mannose receptor family. East, L., Isacke, C.M. Biochim. Biophys. Acta (2002) [Pubmed]
  18. Fetal and neonatal murine skin harbors Langerhans cell precursors. Chang-Rodriguez, S., Hoetzenecker, W., Schwärzler, C., Biedermann, T., Saeland, S., Elbe-Bürger, A. J. Leukoc. Biol. (2005) [Pubmed]
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