The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

S100G  -  S100 calcium binding protein G

Bos taurus

Synonyms: CABP, CALB3, S100D
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CALB3

  • A technique for proton labelling of selected amino acids in deuterated calbindin D9K, heterologously expressed in E. coli, was developed in order to simplify and obtain higher resolution in 1H-NMR spectra [1].

High impact information on CALB3

  • Effects of calcium binding on the side-chain methyl dynamics of calbindin D9k: a 2H NMR relaxation study [2].
  • The structure of the half-saturated cadmium state was compared with the previously determined solution structures of the apo and fully calcium saturated calbindin D9k [3].
  • To circumvent this problem, an absolutely conserved glutamic acid residue in the C-terminal binding site (site II) has been mutated to glutamine (E65Q), causing a substantial reduction in calcium affinity and permitting detailed two-dimensional 1H NMR analysis of calbindin D9k with a calcium ion bound only in the N-terminal EF-hand [4].
  • Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography [5].
  • The kinetics of lanthanide (III) exchange for calcium(II) in the C-terminal EF-hand of the protein calbindin D9k have been studied by one-dimensional (1D) stopped-flow NMR [6].

Biological context of CALB3


Anatomical context of CALB3


Associations of CALB3 with chemical compounds


Other interactions of CALB3

  • The expression of calbindin-D9K (CaBP9K) and calbindin-D28K (CaBP28K) genes in the reproductive system is well established for rodent and avian species, but not for domestic livestock [18].
  • Our immunocytochemical results show that ovine, bovine and caprine interplacentomal trophoblast have high levels of calbindin-D9k, about eight to ten times more than in the placentomal region [13].

Analytical, diagnostic and therapeutic context of CALB3


  1. Selective proton labelling of amino acids in deuterated bovine calbindin D9K. A way to simplify 1H-NMR spectra. Brodin, P., Drakenberg, T., Thulin, E., Forsén, S., Grundström, T. Protein Eng. (1989) [Pubmed]
  2. Effects of calcium binding on the side-chain methyl dynamics of calbindin D9k: a 2H NMR relaxation study. Johnson, E., Chazin, W.J., Rance, M. J. Mol. Biol. (2006) [Pubmed]
  3. Solution structure of (Cd2+)1-calbindin D9k reveals details of the stepwise structural changes along the Apo-->(Ca2+)II1-->(Ca2+)I,II2 binding pathway. Akke, M., Forsén, S., Chazin, W.J. J. Mol. Biol. (1995) [Pubmed]
  4. Two-dimensional 1H nuclear magnetic resonance studies of the half-saturated (Ca2+)1 state of calbindin D9k. Further implications for the molecular basis of cooperative Ca2+ binding. Carlström, G., Chazin, W.J. J. Mol. Biol. (1993) [Pubmed]
  5. Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography. Svensson, L.A., Thulin, E., Forsén, S. J. Mol. Biol. (1992) [Pubmed]
  6. An NMR method for studying the kinetics of metal exchange in biomolecular systems. Barbieri, R., Hore, P.J., Luchina, C., Pierattelli, R. J. Biomol. NMR (2002) [Pubmed]
  7. Paramagnetism-based versus classical constraints: an analysis of the solution structure of Ca Ln calbindin D9k. Bertini, I., Donaire, A., Jiménez, B., Luchinat, C., Parigi, G., Piccioli, M., Poggi, L. J. Biomol. NMR (2001) [Pubmed]
  8. Design and synthesis of the pseudo-EF hand in calbindin D9K: effect of amino acid substitutions in the alpha-helical regions. Tsuji, T., Kaiser, E.T. Proteins (1991) [Pubmed]
  9. Expression of calbindin-D9k messenger ribonucleic acid in the gastrointestinal tract of dairy cattle. Yamagishi, N., Yukawa, Y.A., Ishiguro, N., Soeta, S., Lee, I.H., Oboshi, K., Yamada, H. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2002) [Pubmed]
  10. Coupling of ligand binding and dimerization of helix-loop-helix peptides: spectroscopic and sedimentation analyses of calbindin D9k EF-hands. Julenius, K., Robblee, J., Thulin, E., Finn, B.E., Fairman, R., Linse, S. Proteins (2002) [Pubmed]
  11. On the pH dependence of amide proton exchange rates in proteins. Eriksson, M.A., Härd, T., Nilsson, L. Biophys. J. (1995) [Pubmed]
  12. Calbindin-D9k expression in the pregnant cow uterus and placenta. Reiswig, J.D., Frazer, G.S., Inpanbutr, N. Histochem. Cell Biol. (1995) [Pubmed]
  13. Calcium transport and the localisation of calbindin-D9k in the ruminant placenta during the second half of pregnancy. Wooding, F.B., Morgan, G., Jones, G.V., Care, A.D. Cell Tissue Res. (1996) [Pubmed]
  14. The rate and structural consequences of proline cis-trans isomerization in calbindin D9k: NMR studies of the minor (cis-Pro43) isoform and the Pro43Gly mutant. Kördel, J., Forsén, S., Drakenberg, T., Chazin, W.J. Biochemistry (1990) [Pubmed]
  15. Structural basis for the negative allostery between Ca(2+)- and Mg(2+)-binding in the intracellular Ca(2+)-receptor calbindin D9k. Andersson, M., Malmendal, A., Linse, S., Ivarsson, I., Forsén, S., Svensson, L.A. Protein Sci. (1997) [Pubmed]
  16. Effect of amino acid substitutions and deletions on the thermal stability, the pH stability and unfolding by urea of bovine calbindin D9k. Wendt, B., Hofmann, T., Martin, S.R., Bayley, P., Brodin, P., Grundström, T., Thulin, E., Linse, S., Forsén, S. Eur. J. Biochem. (1988) [Pubmed]
  17. Kinetics of calcium binding to calbindin mutants. Forsén, S., Linse, S., Thulin, E., Lindegård, B., Martin, S.R., Bayley, P.M., Brodin, P., Grundström, T. Eur. J. Biochem. (1988) [Pubmed]
  18. CaBP9K levels during the luteal and follicular phases of the estrous cycle in the bovine uterus. Inpanbutr, N., Miller, E.K., Petroff, B.K., Iacopino, A.M. Biol. Reprod. (1994) [Pubmed]
  19. Structure-function relationships in EF-hand Ca2+-binding proteins. Protein engineering and biophysical studies of calbindin D9k. Linse, S., Brodin, P., Drakenberg, T., Thulin, E., Sellers, P., Elmdén, K., Grundström, T., Forsén, S. Biochemistry (1987) [Pubmed]
  20. Identification of an isoaspartyl linkage formed upon deamidation of bovine calbindin D9k and structural characterization by 2D 1H NMR. Chazin, W.J., Kördel, J., Thulin, E., Hofmann, T., Drakenberg, T., Forsén, S. Biochemistry (1989) [Pubmed]
  21. Immunocytochemical and In situ hybridization studies of the distribution of calbindin D9k in the bovine placenta throughout pregnancy. Nikitenko, L., Morgan, G., Kolesnikov, S.I., Wooding, F.B. J. Histochem. Cytochem. (1998) [Pubmed]
WikiGenes - Universities