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MeSH Review

Rats, Brattleboro

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Disease relevance of Rats, Brattleboro


Psychiatry related information on Rats, Brattleboro


High impact information on Rats, Brattleboro

  • This defect has been presumed to be at the genomic or transcriptional level, as AVP messenger is reported to be drastically reduced, if not absent, from the hypothalamus of Brattleboro rats [8].
  • Homozygous (di/di) Brattleboro rats have normal hypothalamic levels of oxytocin and neurophysin I, but undetectable levels of neurophysin II and arginine-vasopressin (AVP) [8].
  • In vivo, AVP is able to stimulate ACTH secretion, and Brattleboro rats, deficient in AVP, show a reduced activity of the hypothalamo-hypophysial-adrenocortical system (HHCS) (see ref. 13 for references) [9].
  • Homozygous Brattleboro rats (deficient in vasopressin) have magnocellular neurons that contain dynorphin separate from oxytocin [10].
  • The activity of angiotensin-converting enzyme is significantly higher in the intermediate and posterior pituitary lobes of Brattleboro rats than in Long-Evans control rats [11].

Chemical compound and disease context of Rats, Brattleboro


Biological context of Rats, Brattleboro


Anatomical context of Rats, Brattleboro


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Gene context of Rats, Brattleboro


Analytical, diagnostic and therapeutic context of Rats, Brattleboro


  1. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Schmale, H., Richter, D. Nature (1984) [Pubmed]
  2. Functional development of grafted vasopressin neurons. Gash, D., Sladek, J.R., Sladek, C.D. Science (1980) [Pubmed]
  3. Collecting duct (Na+/K+)-ATPase activity is correlated with urinary sodium excretion in rat nephrotic syndromes. Deschênes, G., Doucet, A. J. Am. Soc. Nephrol. (2000) [Pubmed]
  4. Persistent phenotypic correction of central diabetes insipidus using adeno-associated virus vector expressing arginine-vasopressin in Brattleboro rats. Ideno, J., Mizukami, H., Honda, K., Okada, T., Hanazono, Y., Kume, A., Saito, T., Ishibashi, S., Ozawa, K. Mol. Ther. (2003) [Pubmed]
  5. Vasopressin-independent regulation of collecting duct aquaporin-2 in food deprivation. Wilke, C., Sheriff, S., Soleimani, M., Amlal, H. Kidney Int. (2005) [Pubmed]
  6. Increased atrial natriuretic peptide (6-33) binding sites in the subfornical organ of water deprived and Brattleboro rats. Saavedra, J.M., Israel, A., Correa, F.M., Kurihara, M. Proc. Soc. Exp. Biol. Med. (1986) [Pubmed]
  7. Circadian rhythms in vasopressin deficient rats. Groblewski, T.A., Nunez, A.A., Gold, R.M. Brain Res. Bull. (1981) [Pubmed]
  8. Immunoreactive arginine-vasopressin in Brattleboro rat ovary. Lim, A.T., Lolait, S.J., Barlow, J.W., Autelitano, D.J., Toh, B.H., Boublik, J., Abraham, J., Johnston, C.I., Funder, J.W. Nature (1984) [Pubmed]
  9. The vasopressin receptor antagonist dPTyr (Me) AVP does not prevent stress-induced ACTH and corticosterone release. Mormède, P. Nature (1983) [Pubmed]
  10. Dynorphin and vasopressin: common localization in magnocellular neurons. Watson, S.J., Akil, H., Fischli, W., Goldstein, A., Zimmerman, E., Nilaver, G., van wimersma Griedanus, T.B. Science (1982) [Pubmed]
  11. High angiotensin-converting enzyme activity in the neurohypophysis of Brattleboro rats. Chevillard, C., Saavedra, J.M. Science (1982) [Pubmed]
  12. Enkephalin convertase demonstrated in the pituitary and adrenal gland by [3H]guanidinoethylmercaptosuccinic acid autoradiography: dehydration decreases neurohypophyseal levels. Strittmatter, S.M., Lynch, D.R., De Souza, E.B., Snyder, S.H. Endocrinology (1985) [Pubmed]
  13. Cardiac haemodynamic effects of the non-peptide, angiotensin II-receptor antagonist, DuP 753, in conscious Long Evans and Brattleboro rats. Batin, P., Gardiner, S.M., Compton, A.M., Kemp, P.A., Bennett, T. Br. J. Pharmacol. (1991) [Pubmed]
  14. Exogenous corticosterone acetate attenuates the hypotension induced by ganglion blockade in conscious Long Evans and Brattleboro rats. Foulkes, R., Gardiner, S.M., Bennett, T. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  15. Cardiovascular interactions between vasopressin, angiotensin and noradrenaline in the Brattleboro rat. Laycock, J.F., Lightman, S.L. Br. J. Pharmacol. (1989) [Pubmed]
  16. Effects of long-term lithium administration on renal structure and function in rats. A distinctive tubular lesion. Kling, M.A., Fox, J.G., Johnston, S.M., Tolkoff-Rubin, N.E., Rubin, R.H., Colvin, R.B. Lab. Invest. (1984) [Pubmed]
  17. Arginine vasopressin gene regulation in the homozygous Brattleboro rat. Kim, J.K., Soubrier, F., Michel, J.B., Bankir, L., Corvol, P., Schrier, R.W. J. Clin. Invest. (1990) [Pubmed]
  18. Differential cardiovascular effects of centrally administered vasopressin in conscious Long Evans and Brattleboro rats. Harland, D., Gardiner, S.M., Bennett, T. Circ. Res. (1989) [Pubmed]
  19. Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct. Hoffert, J.D., Chou, C.L., Fenton, R.A., Knepper, M.A. J. Biol. Chem. (2005) [Pubmed]
  20. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. Kim, D., Sands, J.M., Klein, J.D. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  21. Suprachiasmatic nucleus vasopressin messenger RNA: circadian variation in normal and Brattleboro rats. Uhl, G.R., Reppert, S.M. Science (1986) [Pubmed]
  22. Constitutive nitric oxide synthase in hypothalami of normal and hereditary diabetes insipidus rats and mice: role of nitric oxide in osmotic regulation and its mechanism. Wang, H., Morris, J.F. Endocrinology (1996) [Pubmed]
  23. UT-A2: a 55-kDa urea transporter in thin descending limb whose abundance is regulated by vasopressin. Wade, J.B., Lee, A.J., Liu, J., Ecelbarger, C.A., Mitchell, C., Bradford, A.D., Terris, J., Kim, G.H., Knepper, M.A. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  24. Arginine vasopressin as an intragonadal hormone in Brattleboro rats: presence of a testicular vasopressin-like peptide and functional vasopressin receptors. Kasson, B.G., Hsueh, A.J. Endocrinology (1986) [Pubmed]
  25. Effects of vasopressin and corticosterone on fatty acid metabolism and on the activities of glycerol phosphate acyltransferase and phosphatidate phosphohydrolase in rat hepatocytes. Pollard, A.D., Brindley, D.N. Biochem. J. (1984) [Pubmed]
  26. L-histidine augments the response to 1-deamino-8-D-arginine vasopressin in Brattleboro homozygous (di/di) rats. Charnogursky, G., Moses, A.M., Coulson, R., Bernstein, M., Carvounis, C.P. J. Clin. Invest. (1990) [Pubmed]
  27. Do vasopressin-related peptides induce hippocampal corticosterone receptors? Implications for aging. Sapolsky, R.M., Krey, L.C., McEwen, B.S., Rainbow, T.C. J. Neurosci. (1984) [Pubmed]
  28. Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity. Li, Y., Shaw, S., Kamsteeg, E.J., Vandewalle, A., Deen, P.M. J. Am. Soc. Nephrol. (2006) [Pubmed]
  29. Renal tubular and vascular urea transporters: influence of antidiuretic hormone on messenger RNA expression in Brattleboro rats. Promeneur, D., Bankir, L., Hu, M.C., Trinh-Trang-Tan, M.M. J. Am. Soc. Nephrol. (1998) [Pubmed]
  30. Regulation of aldose reductase, sorbitol dehydrogenase, and taurine cotransporter mRNA in rat medulla. Martial, S., Price, S.R., Sands, J.M. J. Am. Soc. Nephrol. (1995) [Pubmed]
  31. Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance. Cai, Q., Dmitrieva, N.I., Ferraris, J.D., Brooks, H.L., van Balkom, B.W., Burg, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  32. Arginine vasopressin modulates expression of neuronal NOS in rat renal medulla. Martin, P.Y., Bianchi, M., Roger, F., Niksic, L., Féraille, E. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  33. Expression of aquaporins in the renal connecting tubule. Coleman, R.A., Wu, D.C., Liu, J., Wade, J.B. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  34. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Zhang, M.Z., Sanchez Lopez, P., McKanna, J.A., Harris, R.C. Endocrinology (2004) [Pubmed]
  35. Regulation of collecting duct AQP3 expression: response to mineralocorticoid. Kwon, T.H., Nielsen, J., Masilamani, S., Hager, H., Knepper, M.A., Frokiaer, J., Nielsen, S. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  36. Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat. DiGiovanni, S.R., Nielsen, S., Christensen, E.I., Knepper, M.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  37. Fluid and electrolyte handling in Long Evans and Brattleboro rats following injection of polyethylene glycol. Bennett, T., Gardiner, S.M. J. Physiol. (Lond.) (1986) [Pubmed]
  38. Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Petrovic, S., Amlal, H., Sun, X., Karet, F., Barone, S., Soleimani, M. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  39. Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla. Zhang, M.Z., Hao, C.M., Breyer, M.D., Harris, R.C., McKanna, J.A. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
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