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Ctsg  -  cathepsin G

Rattus norvegicus

Synonyms: Cathepsin G
 
 
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Disease relevance of Ctsg_predicted

 

High impact information on Ctsg_predicted

 

Biological context of Ctsg_predicted

 

Anatomical context of Ctsg_predicted

  • Susceptibility of soluble and matrix fibronectins to degradation by tissue proteinases, mast cell chymase and cathepsin G [9].
  • Effective concentrations for the combined cathepsin G and elastase in the incubation mixture were similar to the concentrations of these enzymes in PMN-conditioned medium that produced cytotoxicity to hepatocytes [10].
  • Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions [2].
  • In the same stimulated macrophages there was little activity against type I collagen (associated with MMP-13 [collagenase-3] on the basis of Western blotting), no activity suggestive of stromelysin or matrilysin, and no measurable secretion of the serine proteinases, elastase and cathepsin G [11].
  • Rat leukocytes from inflammatory peritoneal exudates respond in vitro to a variety of chemotactic and phagocytic stimuli by releasing both elastase and cathepsin G neutral proteinase enzyme activities [12].
 

Associations of Ctsg_predicted with chemical compounds

  • Leucocyte proteinases, e.g. leucocyte elastase and cathepsin G, are inhibited by heparin [13].
  • By contrast, the serine protease inhibitors, aprotinin and 4-(2-aminoethyl)-benzene-sulfonyl fluoride, were less effective in inhibiting cathepsin G and elastase activities as well as cytotoxicity caused by the purified proteases or PMN-conditioned medium [10].
  • The six half-cystine residues in the mouse mast cell protease are located in the same positions as in the rat mast cell proteases, cathepsin G, and the lymphocyte proteases, suggesting that they all have identical disulfide bond arrangements [14].
  • Previous studies showed a higher percentage of neutrophils from vitamin A deficient rats are hypersegmented and contain lower levels of cathepsin G than the neutrophils from control rats [15].
  • Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia [16].
 

Other interactions of Ctsg_predicted

  • The effect of THR, but not that of PAR1-AP, was significantly inhibited by hirulog(TM) (60 microg/mL), a specific and stochiometric THR inhibitor or by cathepsin-G (40 mU/mL), an inhibitor of PAR-1 [17].
  • Cytotoxicity of either purified enzyme or of conditioned medium could be prevented by plasma alpha-1-antitrypsin or soybean trypsin-chymotrypsin inhibitor, which were also potent inhibitors of enzymic activity of both cathepsin G and elastase [10].
  • Levels of myeloperoxidase, lysozyme, cathepsin G, alkaline phosphatase, gamma-glutamyltranspeptidase and N-acetyl-beta-glucosaminidase showed no sex-based differences [18].
 

Analytical, diagnostic and therapeutic context of Ctsg_predicted

References

  1. Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G. Björk, P., Ohlsson, K. Biol. Chem. Hoppe-Seyler (1990) [Pubmed]
  2. Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions. Kolpakov, V., D'Adamo, M.C., Salvatore, L., Amore, C., Mironov, A., Iacoviello, L., Donati, M.B. Thromb. Haemost. (1994) [Pubmed]
  3. Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary no-reflow in ischemia/reperfusion-induced acute pancreatitis. von Dobschuetz, E., Hoffmann, T., Messmer, K. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  4. Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. Rafiq, K., Kolpakov, M.A., Abdelfettah, M., Streblow, D.N., Hassid, A., Dell'Italia, L.J., Sabri, A. J. Biol. Chem. (2006) [Pubmed]
  5. Human cathepsin G lacking functional glycosylation site is proteolytically processed and targeted for storage in granules after transfection to the rat basophilic/mast cell line RBL or the murine myeloid cell line 32D. Garwicz, D., Lindmark, A., Gullberg, U. J. Biol. Chem. (1995) [Pubmed]
  6. Human skin chymotryptic proteinase. Isolation and relation to cathepsin g and rat mast cell proteinase I. Schechter, N.M., Fräki, J.E., Geesin, J.C., Lazarus, G.S. J. Biol. Chem. (1983) [Pubmed]
  7. Substrate specificity of two chymotrypsin-like proteases from rat mast cells. Studies with peptide 4-nitroanilides and comparison with cathepsin G. Yoshida, N., Everitt, M.T., Neurath, H., Woodbury, R.G., Powers, J.C. Biochemistry (1980) [Pubmed]
  8. Neutral proteases and disruption of the blood-brain barrier in rat. Armao, D., Kornfeld, M., Estrada, E.Y., Grossetete, M., Rosenberg, G.A. Brain Res. (1997) [Pubmed]
  9. Susceptibility of soluble and matrix fibronectins to degradation by tissue proteinases, mast cell chymase and cathepsin G. Vartio, T., Seppä, H., Vaheri, A. J. Biol. Chem. (1981) [Pubmed]
  10. Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes. Ho, J.S., Buchweitz, J.P., Roth, R.A., Ganey, P.E. J. Leukoc. Biol. (1996) [Pubmed]
  11. Characterization of matrix metalloproteinases produced by rat alveolar macrophages. Gibbs, D.F., Warner, R.L., Weiss, S.J., Johnson, K.J., Varani, J. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  12. Stimulated release of neutral proteinases elastase and cathepsin G from inflammatory rat polymorphonuclear leukocytes. Bray, M.A., McKearn-Smith, C., Metz-Virca, G., Bodmer, J.L., Virca, G.D. Inflammation (1987) [Pubmed]
  13. Inhibition of leucocyte elastase by heparin and its derivatives. Redini, F., Tixier, J.M., Petitou, M., Choay, J., Robert, L., Hornebeck, W. Biochem. J. (1988) [Pubmed]
  14. Amino acid sequence of a mouse mucosal mast cell protease. Trong, H.L., Newlands, G.F., Miller, H.R., Charbonneau, H., Neurath, H., Woodbury, R.G. Biochemistry (1989) [Pubmed]
  15. Vitamin A deficiency alters rat neutrophil function. Twining, S.S., Schulte, D.P., Wilson, P.M., Fish, B.L., Moulder, J.E. J. Nutr. (1997) [Pubmed]
  16. Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia. Sukura, A., Konttinen, Y.T., Sepper, R., Kaartinen, L., Sorsa, T., Lindberg, L.A. J. Clin. Microbiol. (1995) [Pubmed]
  17. Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells. Meli, R., Raso, G.M., Cicala, C., Esposito, E., Fiorino, F., Cirino, G. J. Neurochem. (2001) [Pubmed]
  18. Biochemical studies of neutrophils from male and female rats: a differential response to basement membrane treated with nephrotoxic antiserum. Unarska-Jachimczyk, M., Robinson, G.B., Keer, J. Biochim. Biophys. Acta (1988) [Pubmed]
  19. Turnover and distribution of cathepsin G in the rat. Björk, P., Luts, A., Sundler, F., Ohlsson, K. Scand. J. Clin. Lab. Invest. (1993) [Pubmed]
  20. Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis. Coffey, J.W., Salvador, R.A. Biochim. Biophys. Acta (1981) [Pubmed]
 
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