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Gene Review

Avpr1a  -  arginine vasopressin receptor 1A

Rattus norvegicus

Synonyms: AVPR, AVPR V1a, Antidiuretic hormone receptor 1a, V1a, V1aR, ...
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Disease relevance of Avpr1a

  • By blocking the vascular V1a receptors, it may compromise the patient's ability to maintain arterial blood pressure during hemorrhage [1].
  • Experiments were performed to get insight into the role of AVP receptor V(1a) regulation with age, i.e., during development and maintenance of high blood pressure [2].
  • Dehydration decreased expression approximately 50% in renal vessels independent of rat strain; water loading increased V1a mRNA [3].
  • Chronic metabolic acidosis increased V1a receptor mRNA expression in the CD but decreased V2 receptor mRNA expression [4].
  • The study provides evidence for significant changes of expression of AT1aR mRNA, V1aR mRNA and NOS1 mRNA in the specific brain regions of rats with the renovascular hypertension [5].

Psychiatry related information on Avpr1a

  • Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour [6].
  • This study explores the effects of enhancing vasopressin V1a receptor expression in the septum using viral vector-mediated gene transfer on social discrimination and social interactions [6].
  • In a social discrimination paradigm, only V1aR-AAV-treated animals succeeded in discriminating a previously encountered from a novel juvenile after an interexposure interval (IEI) of more than 2 h, demonstrating the functional incorporation of the vole V1a receptor in the rat septal circuits underlying short-term memory processes [6].
  • Blocking the endogenous AVP by 25 or 1 microg of the V1a receptor antagonist d(CH(2))(5)[Tyr(Me)(2)]AVP (AAVP) before MPH treatment significantly augmented the motor activity in SO rats only and abolished the differences seen between SO and PE animals after MPH application [7].

High impact information on Avpr1a


Chemical compound and disease context of Avpr1a


Biological context of Avpr1a


Anatomical context of Avpr1a


Associations of Avpr1a with chemical compounds

  • Moreover, when Tyr115 is replaced by an Asp and a Phe, the amino acids naturally occurring in the V2 and in the OT receptor subtypes, the agonist selectivity of the V1a receptor switches accordingly [19].
  • Arginine-vasopressin (AVP) in the septum and hippocampus are thought to be involved in memory and learning, and their receptors have been classified into three subtypes, V1a, V1b and V2 [17].
  • Previous studies have demonstrated that both the V2-receptor agonist, 1-desamino-8-D-arginine vasopressin (dDAVP), and the V1a-receptor agonist, [Phe2, Orn8]vasotocin (PO-VT), increase intracellular calcium concentration ([Ca2+]i) in the rat inner medullary collecting duct (IMCD) [20].
  • Pretreating VSMCs with chloroquine prevented AVP receptor recycling, indicating that the AVP-receptor complex requires endosomal processing [21].
  • The motor actions of centrally injected AVP, as well as septal AVP receptor characteristics (number and affinity), and AVP-stimulated phosphoinositide (PI) hydrolysis were then investigated in long-term castrated and sham control rats [22].

Physical interactions of Avpr1a


Regulatory relationships of Avpr1a

  • Antagonists for oxytocin ([des-glycinamide9,d(CH2)5(1),O-Me-Tyr2,Thr4,Orn8]vaso tocin), V2 ([d(CH2)5(1),D-Ile2,Ile4,Arg8]vasopressin), and V1a ([d(CH2)5(1),O-Me-Tyr2,Arg8]vasopressin) receptors partially inhibited the [Ca2+]i response induced by 10 nM AVP (89.5, 81.6, and 51.4% inhibition, respectively) [26].
  • AVP (n = 9) and OT (n = 8) induced increases in [Ca2+]i were completely blocked by the V1A-receptor antagonist d(CH2)5Tyr(Me)2AVP [27].

Other interactions of Avpr1a


Analytical, diagnostic and therapeutic context of Avpr1a

  • Large signals for V1a receptor PCR product were detected in the glomerulus, initial cortical collecting duct, cortical collecting duct, outer medullary collecting duct, inner medullary collecting duct, and arcuate artery [10].
  • The cell response was essentially ascribed to the V1a AVP receptor, whose presence was confirmed by RT-PCR and immunolabelling [16].
  • These observations may be more general, as autoradiography revealed similar lobular distributions of V1a receptors and alpha1 adrenergic receptors; the amounts of both were greatest in hepatocytes surrounding central veins [30].
  • Multiple immunocytochemical labeling combined with confocal microscopy allowed the identification of the V1a-labeled cells as gonadotropes [31].
  • In this study, we investigated the effects of chronic adrenalectomy (ADX) and subsequent treatment with supraphysiological doses of corticosterone (B) on the gene expression of AVP receptors of the V1a subtype in the septum, hippocampus and hypothalamic arcuate (ARC) nucleus using semiquantitative in situ hybridization histochemistry [32].


  1. The role of oxytocin receptors and vasopressin V1a receptors in uterine contractions in rats: implications for tocolytic therapy with oxytocin antagonists. Chan, W.Y., Wo, N.C., Manning, M. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  2. Age-dependent regulation of vasopressin V1a receptors in preglomerular vessels from the spontaneously hypertensive rat. Vågnes B, Ø.B., Hansen, F.H., Christiansen, R.E., Gjerstad, C., Iversen, B.M. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  3. Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states. Vagnes, O.B., Hansen, F.H., Feng, J.J., Iversen, B.M., Arendshorst, W.J. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  4. Intranephron localization and regulation of the V1a vasopressin receptor during chronic metabolic acidosis and dehydration in rats. Tashima, Y., Kohda, Y., Nonoguchi, H., Ikebe, M., Machida, K., Star, R.A., Tomita, K. Pflugers Arch. (2001) [Pubmed]
  5. Altered expression of angiotensin AT1a and vasopressin V1a receptors and nitric oxide synthase mRNA in the brain of rats with renovascular hypertension. Jackiewicz, E., Szczepanska-Sadowska, E., Dobruch, J. J. Physiol. Pharmacol. (2004) [Pubmed]
  6. Viral vector-mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour. Landgraf, R., Frank, E., Aldag, J.M., Neumann, I.D., Sharer, C.A., Ren, X., Terwilliger, E.F., Niwa, M., Wigger, A., Young, L.J. Eur. J. Neurosci. (2003) [Pubmed]
  7. Methylphenidate-induced motor activity in rats: modulation by melatonin and vasopressin. Appenrodt, E., Schwarzberg, H. Pharmacol. Biochem. Behav. (2003) [Pubmed]
  8. Molecular cloning and expression of a rat V1a arginine vasopressin receptor. Morel, A., O'Carroll, A.M., Brownstein, M.J., Lolait, S.J. Nature (1992) [Pubmed]
  9. Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. Teitelbaum, I., McGuinness, S. J. Clin. Invest. (1995) [Pubmed]
  10. Different localization and regulation of two types of vasopressin receptor messenger RNA in microdissected rat nephron segments using reverse transcription polymerase chain reaction. Terada, Y., Tomita, K., Nonoguchi, H., Yang, T., Marumo, F. J. Clin. Invest. (1993) [Pubmed]
  11. Subchronic phencyclidine administration alters central vasopressin receptor binding and social interaction in the rat. Tanaka, K., Suzuki, M., Sumiyoshi, T., Murata, M., Tsunoda, M., Kurachi, M. Brain Res. (2003) [Pubmed]
  12. Elevation of [Ca2+]i of renal proximal tubular cells and down-regulation of mRNA of PTH-PTHrP, V1a and AT1 receptors in kidney of diabetic rats. Marcinkowski, W., Zhang, G., Smogorzewski, M., Massry, S.G. Kidney Int. (1997) [Pubmed]
  13. Contribution of vascular and tubular effects of arginine-vasopressin to the development of deoxycorticosterone acetate (DOCA)-salt hypertension in rats. Hofbauer, K.G., Mah, S.C., Wood, J.M., Baum, H.P., Hänni, H., Opperman, J.R., Kraetz, J. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. (1984) [Pubmed]
  14. Treatment with cilazapril, angiotensin-converting enzyme inhibitor, changes the affinity of arginine vasopressin receptor in the kidney of the spontaneously hypertensive rat. Nishida, N., Ogura, T., Yamauchi, T., Hosoya, M., Ota, Z. Res. Commun. Chem. Pathol. Pharmacol. (1994) [Pubmed]
  15. Localization of the vasopressin V1a and V2 receptors within the renal cortical and medullary circulation. Park, F., Mattson, D.L., Skelton, M.M., Cowley, A.W. Am. J. Physiol. (1997) [Pubmed]
  16. Anatomical and functional evidence for a role of arginine-vasopressin (AVP) in rat olfactory epithelium cells. Levasseur, G., Baly, C., Grébert, D., Durieux, D., Salesse, R., Caillol, M. Eur. J. Neurosci. (2004) [Pubmed]
  17. Evidence for the existence of vasopressin V2 receptor mRNA in rat hippocampus. Hirasawa, A., Nakayama, Y., Ishiharada, N., Honda, K., Saito, R., Tsujimoto, G., Takano, Y., Kamiya, H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  18. Cellular expression of V1a vasopressin receptor mRNA in the female rat preoptic area: effects of oestrogen. Kalamatianos, T., Kalló, I., Goubillon, M.L., Coen, C.W. J. Neuroendocrinol. (2004) [Pubmed]
  19. Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor. Chini, B., Mouillac, B., Ala, Y., Balestre, M.N., Trumpp-Kallmeyer, S., Hoflack, J., Elands, J., Hibert, M., Manning, M., Jard, S. EMBO J. (1995) [Pubmed]
  20. Evidence for dual signaling pathways for V2 vasopressin receptor in rat inner medullary collecting duct. Ecelbarger, C.A., Chou, C.L., Lolait, S.J., Knepper, M.A., DiGiovanni, S.R. Am. J. Physiol. (1996) [Pubmed]
  21. Demonstration of processing and recycling of biologically active V1 vasopressin receptors in vascular smooth muscle. Briner, V.A., Williams, B., Tsai, P., Schrier, R.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Septal arginine vasopressin (AVP) receptor regulation in rats depleted of septal AVP following long-term castration. Poulin, P., Pittman, Q.J. J. Neurosci. (1991) [Pubmed]
  23. Comparative effects of loop diuretics on AVP-receptor binding and AVP-sensitive adenylate cyclase activity. Osajima, A., Anai, H., Segawa, K., Muta, T., Takasugi, M., Kuroiwa, A. Nippon Jinzo Gakkai shi. (1992) [Pubmed]
  24. Characterization and localization of oxytocin receptors in the rat testis. Bathgate, R.A., Sernia, C. J. Endocrinol. (1994) [Pubmed]
  25. Attenuation of genetic hypertension after short-term vasopressin V1A receptor antagonism. Burrell, L.M., Phillips, P.A., Risvanis, J., Aldred, K.L., Hutchins, A.M., Johnston, C.I. Hypertension (1995) [Pubmed]
  26. Vasopressin and oxytocin receptors coupled to Ca2+ mobilization in rat inner medullary collecting duct. Maeda, Y., Han, J.S., Gibson, C.C., Knepper, M.A. Am. J. Physiol. (1993) [Pubmed]
  27. Functional evidence for the regulation of cytosolic Ca2+ activity via V1A-receptors and beta-adrenoceptors in rat CCD. Ankorina-Stark, I., Haxelmans, S., Schlatter, E. Cell Calcium (1997) [Pubmed]
  28. Molecular cloning and expression of rat V1a and V2 arginine vasopressin receptors. Morel, A., Lolait, S.J., Brownstein, M.J. Regul. Pept. (1993) [Pubmed]
  29. Vasopressin-activated calcium-mobilizing (VACM-1) receptor mRNA is present in peripheral organs and the central nervous system of the laboratory rat. Ceremuga, T.E., Yao, X.L., McCabe, J.T. Endocr. Res. (2001) [Pubmed]
  30. Hormone receptor gradients supporting directional Ca2+ signals: direct evidence in rat hepatocytes. Clair, C., Tran, D., Boucherie, S., Claret, M., Tordjmann, T., Combettes, L. J. Hepatol. (2003) [Pubmed]
  31. Immunocytochemical localization of vasopressin v1a receptors in the rat pituitary gonadotropes. Orcel, H., Tobin, V.A., Alonso, G., Rabié, A. Endocrinology (2002) [Pubmed]
  32. Corticosteroid regulation of gene expression and binding characteristics of vasopressin receptors in the rat brain. Patchev, V.K., Almeida, O.F. Eur. J. Neurosci. (1995) [Pubmed]
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