Gene Review:
FDFT1 - farnesyl-diphosphate farnesyltransferase 1
Homo sapiens
Synonyms:
DGPT, ERG9, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, SQS, ...
- A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma. Hughes, S.J., Glover, T.W., Zhu, X.X., Kuick, R., Thoraval, D., Orringer, M.B., Beer, D.G., Hanash, S. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase. Summers, C., Karst, F., Charles, A.D. Gene (1993)
- Dermatomyositis and drugs. Dourmishev, A.L., Dourmishev, L.A. Adv. Exp. Med. Biol. (1999)
- Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols. Cohen, L.H., van Miert, E., Griffioen, M. Biochim. Biophys. Acta (1989)
- Recently characterised autoantibodies and their clinical significance. Sturgess, A. Australian and New Zealand journal of medicine. (1992)
- Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor. Faust, J.R., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (1979)
- Squalene synthase: structure and regulation. Tansey, T.R., Shechter, I. Prog. Nucleic Acid Res. Mol. Biol. (2001)
- Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities. Kuswik-Rabiega, G., Rilling, H.C. J. Biol. Chem. (1987)
- Proton transfer in gramicidin channels is modulated by the thickness of monoglyceride bilayers. Chernyshev, A., Armstrong, K.M., Cukierman, S. Biophys. J. (2003)
- Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1. Schechter, I., Conrad, D.G., Hart, I., Berger, R.C., McKenzie, T.L., Bleskan, J., Patterson, D. Genomics (1994)
- Transcriptional downregulation of sterol metabolism genes in murine liver exposed to acute hypobaric hypoxia. Dolt, K.S., Karar, J., Mishra, M.K., Salim, J., Kumar, R., Grover, S.K., Qadar Pasha, M.A. Biochem. Biophys. Res. Commun. (2007)
- DNA stability in plant tissues: implications for the possible transfer of genes from genetically modified food. Chiter, A., Forbes, J.M., Blair, G.E. FEBS Lett. (2000)
- Children as a sensitive subgroup and their role in regulatory toxicology: DGPT workshop report. Schwenk, M., Gundert-Remy, U., Heinemeyer, G., Olejniczak, K., Stahlmann, R., Kaufmann, W., Bolt, H.M., Greim, H., von Keutz, E., Gelbke, H.P. Arch. Toxicol. (2003)
- Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana. Urbina, J.A., Concepcion, J.L., Rangel, S., Visbal, G., Lira, R. Mol. Biochem. Parasitol. (2002)
- Current, new and future treatments in dyslipidaemia and atherosclerosis. Chong, P.H., Bachenheimer, B.S. Drugs (2000)
- On the origin of closing flickers in gramicidin channels: a new hypothesis. Armstrong, K.M., Cukierman, S. Biophys. J. (2002)
- Inhibition of a plant sesquiterpene cyclase by mevinolin. Vögeli, U., Chappell, J. Arch. Biochem. Biophys. (1991)
- The isoprenoid pathway in the ectomycorrhizal fungus Tuber borchii Vittad.: cloning and characterisation of the tbhmgr, tbfpps and tbsqs genes. Guidi, C., Zeppa, S., Annibalini, G., Pierleoni, R., Guescini, M., Buffalini, M., Zambonelli, A., Stocchi, V. Curr. Genet. (2006)
- Upregulation of Isoprenoid Pathway Genes During Enhanced Saikosaponin Biosynthesis in the Hairy Roots of Bupleurum falcatum. Kim, Y.S., Cho, J.H., Ahn, J., Hwang, B. Mol. Cells (2006)
- Squalene epoxidase as hypocholesterolemic drug target revisited. Chugh, A., Ray, A., Gupta, J.B. Prog. Lipid Res. (2003)
- Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo. Bennett, M.K., Toth, J.I., Osborne, T.F. J. Biol. Chem. (2004)
- Human serum albumin inhibits prostacyclin production by endothelial cells: the relation of the inhibitory activity to sulfhydryl groups in albumin. Murohara, Y., Yui, Y., Hattori, R., Kadota, K., Kawai, C. Jpn. Circ. J. (1991)
- Structure and regulation of mammalian squalene synthase. Tansey, T.R., Shechter, I. Biochim. Biophys. Acta (2000)