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Gene Review

Nrf1  -  nuclear respiratory factor 1

Rattus norvegicus

Synonyms: Alpha palindromic-binding protein, Alpha-pal, NRF-1, Nuclear respiratory factor 1
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Disease relevance of Nrf1_predicted

  • In mitochondria-rich rat hepatoma cells that overexpress NRF-1, basal and oxidant-induced increases were found in Tfam expression and mtDNA content [1].

High impact information on Nrf1_predicted


Biological context of Nrf1_predicted


Anatomical context of Nrf1_predicted


Associations of Nrf1_predicted with chemical compounds


Other interactions of Nrf1_predicted

  • The transcriptional response also included nuclear accumulation of peroxisome proliferator-activated receptor-gamma co-activator 1 (PGC-1) and mRNA expression for redox-regulated nuclear respiratory factors (NRF-1 and -2) [11].
  • PIN possesses two binding grooves, that have been shown to interact with several targets, including neuronal NO synthase, dynein intermediate chain, myosin V, the proapoptotic protein Bim, the scaffolding proteins DAP1alpha and gephyrin, and the transcription factor NRF-1 [12].
  • In testing this hypothesis in rat liver, we found that LPS induces NRF-1 protein expression and activity accompanied by mRNA expression for mitochondrial transcription factor-A, mtDNA polymerase gamma, NRF-2, and single-stranded DNA-binding protein [4].
  • Electrophoretic mobility shift assay revealed that the ARE complex, consisting of Nrf-1/2 and Maf proteins, was activated 12 to 48 h after sulfur amino acid deprivation (SAAD) [13].
  • Additional small deletion series and point mutation experiments confirmed the presence of two functional NRF-2 sites arranged in a tandem repeat, as well as a NRF-1 site and an Sp1 site [14].

Analytical, diagnostic and therapeutic context of Nrf1_predicted


  1. Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. Piantadosi, C.A., Suliman, H.B. J. Biol. Chem. (2006) [Pubmed]
  2. Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation. Xia, Y., Buja, L.M., Scarpulla, R.C., McMillin, J.B. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Expression of mitochondrial genes and of the transcription factors involved in the biogenesis of mitochondria Tfam, NRF-1 and NRF-2, in rat liver, testis and brain. Escrivá, H., Rodríguez-Peña, A., Vallejo, C.G. Biochimie (1999) [Pubmed]
  4. Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. Suliman, H.B., Carraway, M.S., Welty-Wolf, K.E., Whorton, A.R., Piantadosi, C.A. J. Biol. Chem. (2003) [Pubmed]
  5. Regulation of mitochondrial transcription factor A expression by high glucose. Choi, Y.S., Lee, K.U., Pak, Y.K. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  6. Activation of the cytochrome c gene by electrical stimulation in neonatal rat cardiac myocytes. Role of NRF-1 and c-Jun. Xia, Y., Buja, L.M., McMillin, J.B. J. Biol. Chem. (1998) [Pubmed]
  7. Delayed ischemic preconditioning activates nuclear-encoded electron-transfer-chain gene expression in parallel with enhanced postanoxic mitochondrial respiratory recovery. McLeod, C.J., Jeyabalan, A.P., Minners, J.O., Clevenger, R., Hoyt, R.F., Sack, M.N. Circulation (2004) [Pubmed]
  8. Leptin and the control of respiratory gene expression in muscle. McClelland, G.B., Kraft, C.S., Michaud, D., Russell, J.C., Mueller, C.R., Moyes, C.D. Biochim. Biophys. Acta (2004) [Pubmed]
  9. Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Stirone, C., Duckles, S.P., Krause, D.N., Procaccio, V. Mol. Pharmacol. (2005) [Pubmed]
  10. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Bergeron, R., Ren, J.M., Cadman, K.S., Moore, I.K., Perret, P., Pypaert, M., Young, L.H., Semenkovich, C.F., Shulman, G.I. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  11. Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. Suliman, H.B., Welty-Wolf, K.E., Carraway, M., Tatro, L., Piantadosi, C.A. Cardiovasc. Res. (2004) [Pubmed]
  12. Cellulose membrane supported peptide arrays for deciphering protein-protein interaction sites: the case of PIN, a protein with multiple natural partners. Lajoix, A.D., Gross, R., Aknin, C., Dietz, S., Granier, C., Laune, D. Mol. Divers. (2004) [Pubmed]
  13. The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells. Kang, K.W., Ryu, J.H., Kim, S.G. Mol. Pharmacol. (2000) [Pubmed]
  14. Functional analysis of the rat cytochrome c oxidase subunit 6A1 promoter in primary neurons. Ongwijitwat, S., Wong-Riley, M.T. Gene (2004) [Pubmed]
  15. Increases in the mitochondrial DNA replication and transcription in the remnant liver of rats. Koyama, H., Kurokawa, T., Nonami, T., Nakao, A., Sugiyama, S., Murakami, T., Shimomura, Y., Takagi, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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