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Gene Review

Spp  -  Signal peptide peptidase

Drosophila melanogaster

Synonyms: CG11840, Dmel\CG11840, SPP, spp
 
 
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Disease relevance of Spp

  • Chlamydia spp. are major causes of important human diseases, but dissecting the host-pathogen interactions has been hampered by the lack of bacterial genetics and the difficulty in carrying out forward genetic screens in mammalian hosts [1].
  • Evolutionary dynamics of wAu-like Wolbachia variants in neotropical Drosophila spp [2].
  • The endosymbiotic bacteria Spiroplasma spp. are vertically transmitted through female hosts and are known to cause selective death of male offspring in insects [3].
  • Wolbachia spp. are intracellular alpha proteobacteria closely related to Rickettsia [4].
  • We also studied resistance/sensitivity to 12 antibiotics for six bacterial isolates such as Enterobacter cloacae, E. sakazakii, K. pneumoniae spp., Providencia rettgeri, P. aeruginosa, and Bacillus cereus [5].
 

High impact information on Spp

  • In the unicellular human parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp., the spliced-leader (SL) RNA is a key molecule in gene expression donating its 5'-terminal region in SL addition trans splicing of nuclear pre-mRNA [6].
  • Unlike the Drosophila HP1 gene, HHP1 is not essential in Tetrahymena spp., and during vegetative growth no clear phenotype is observed in cells lacking Hhp1p (DeltaHHP1) [7].
  • Several genes encoding transcription factors with a helix-loop-helix (HLH) motif are involved in the early process of neural development in Drosophila spp [8].
  • Phosphorylation of histone H1 is developmentally regulated in Drosophila spp [9].
  • Although regions of DNA reacting with anti-Z-DNA antibodies have been identified in the polytene chromosomes of Drosophila spp. and the metaphase chromosomes from a number of different mammalian species, the biological role of this DNA is unknown [10].
 

Biological context of Spp

  • In S. exigua larvae, permissive Spodoptera spp. cultured cells, and nonpermissive D. melanogaster cultured cells early viral gene expression was indicated by the appearance of Lac-Z as early as 3 hr p.i. Late viral gene expression was indicated by the appearance of GUS and occurred only in the permissive cultured cells and larvae [11].
  • Antimutagenic effect of one variety of green pepper (Capsicum spp.) and its possible interference with the nitrosation process [12].
  • This work describes the characterization of a high-affinity binding site for PA1b in a microsomal fraction of Sitophilus spp. extracts [13].
  • The microsatellite variability data from C. rosa and C. fasciventris, together with those of C. capitata, support the hypothesis of an east African origin of the Ceratitis spp [14].
  • We sequenced the internal transcribed spacer (ITS) region of the nuclear ribosomal cistron for 13 of the syngens plus two other Paramecium species and several Tetrahymena spp [15].
 

Anatomical context of Spp

  • However, analysis of published data for thorax length of Drosophila spp [16].
  • We evaluated human urine and chicken feces, two naturally occurring, inexpensive, and readily available substances, as baits for the capture of Anostrepha spp [17].
 

Associations of Spp with chemical compounds

 

Analytical, diagnostic and therapeutic context of Spp

  • Because rambutan has such low rates of infestation by oriental fruit fly and Cryptophlebia spp., the two primary internal-feeding regulatory pests of rambutan in Hawaii, it may be amenable to the alternative treatment efficacy approach to postharvest quarantine treatment [20].

References

  1. Drosophila melanogaster S2 cells: a model system to study Chlamydia interaction with host cells. Elwell, C., Engel, J.N. Cell. Microbiol. (2005) [Pubmed]
  2. Evolutionary dynamics of wAu-like Wolbachia variants in neotropical Drosophila spp. Miller, W.J., Riegler, M. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. Population dynamics of male-killing and non-male-killing spiroplasmas in Drosophila melanogaster. Anbutsu, H., Fukatsu, T. Appl. Environ. Microbiol. (2003) [Pubmed]
  4. Characterization of Wolbachia transfection efficiency by using microinjection of embryonic cytoplasm and embryo homogenate. Xi, Z., Dobson, S.L. Appl. Environ. Microbiol. (2005) [Pubmed]
  5. Isolation and identification of bacteria associated with adult laboratory Mexican fruit flies, Anastrepha ludens (Diptera: Tephritidae). Kuzina, L.V., Peloquin, J.J., Vacek, D.C., Miller, T.A. Curr. Microbiol. (2001) [Pubmed]
  6. Characterization of a multisubunit transcription factor complex essential for spliced-leader RNA gene transcription in Trypanosoma brucei. Schimanski, B., Nguyen, T.N., Günzl, A. Mol. Cell. Biol. (2005) [Pubmed]
  7. A nonessential HP1-like protein affects starvation-induced assembly of condensed chromatin and gene expression in macronuclei of Tetrahymena thermophila. Huang, H., Smothers, J.F., Wiley, E.A., Allis, C.D. Mol. Cell. Biol. (1999) [Pubmed]
  8. A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation. Feder, J.N., Jan, L.Y., Jan, Y.N. Mol. Cell. Biol. (1993) [Pubmed]
  9. Drosophila melanogaster H1 histone is phosphorylated stably. Talmage, D.A., Blumenfeld, M. Mol. Cell. Biol. (1987) [Pubmed]
  10. Binding of anti-Z-DNA antibodies in quiescent and activated lymphocytes: relationship to cell cycle progression and chromatin changes. Staiano-Coico, L., Stollar, B.D., Darzynkiewicz, Z., Dutkowski, R., Weksler, M.E. Mol. Cell. Biol. (1985) [Pubmed]
  11. Passage of Autographa californica nuclear polyhedrosis virus through the midgut epithelium of Spodoptera exigua larvae. Flipsen, J.T., Martens, J.W., van Oers, M.M., Vlak, J.M., van Lent, J.W. Virology (1995) [Pubmed]
  12. Antimutagenic effect of one variety of green pepper (Capsicum spp.) and its possible interference with the nitrosation process. Ramirez-Victoria, P., Guzman-Rincon, J., Espinosa-Aguirre, J.J., Murillo-Romero, S. Mutat. Res. (2001) [Pubmed]
  13. Characterization of a high-affinity binding site for the pea albumin 1b entomotoxin in the weevil Sitophilus. Gressent, F., Rahioui, I., Rahbé, Y. Eur. J. Biochem. (2003) [Pubmed]
  14. Population genetics of the potentially invasive African fruit fly species, Ceratitis rosa and Ceratitis fasciventris (Diptera: Tephritidae). Baliraine, F.N., Bonizzoni, M., Guglielmino, C.R., Osir, E.O., Lux, S.A., Mulaa, F.J., Gomulski, L.M., Zheng, L., Quilici, S., Gasperi, G., Malacrida, A.R. Mol. Ecol. (2004) [Pubmed]
  15. Paramecium aurelia revisited. Coleman, A.W. J. Eukaryot. Microbiol. (2005) [Pubmed]
  16. Sexual size dimorphism in a Drosophila clade, the D. obscura group. Huey, R.B., Moreteau, B., Moreteau, J.C., Gibert, P., Gilchrist, G.W., Ives, A.R., Garland, T., David, J.R. Zoology (Jena) (2006) [Pubmed]
  17. Human urine and chicken feces as fruit fly (Diptera: Tephritidae) attractants for resource-poor fruit growers. Piñero, J., Aluja, M., Vázquez, A., Equihua, M., Varón, J. J. Econ. Entomol. (2003) [Pubmed]
  18. Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target. Gurnett, A.M., Liberator, P.A., Dulski, P.M., Salowe, S.P., Donald, R.G., Anderson, J.W., Wiltsie, J., Diaz, C.A., Harris, G., Chang, B., Darkin-Rattray, S.J., Nare, B., Crumley, T., Blum, P.S., Misura, A.S., Tamas, T., Sardana, M.K., Yuan, J., Biftu, T., Schmatz, D.M. J. Biol. Chem. (2002) [Pubmed]
  19. Plasmodium development in white-eye (kh(w)) and transformed strains (kh43) of Aedes aegypti (Diptera: Culicidae). Beerntsen, B.T., Li, J. J. Med. Entomol. (2006) [Pubmed]
  20. Field infestation of rambutan fruits by internal-feeding pests in Hawaii. McQuate, G.T., Follett, P.A., Yoshimoto, J.M. J. Econ. Entomol. (2000) [Pubmed]
 
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